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Spots Global Cancer Trial Database for Integrated Multiomics and Multilevel Characterization of Haematological Disorders and Malignancies

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Trial Identification

Brief Title: Integrated Multiomics and Multilevel Characterization of Haematological Disorders and Malignancies

Official Title: Integrated Multiomics and Multilevel Characterization of Haematological Disorders and Malignancies

Study ID: NCT04298892

Study Description

Brief Summary: Exploratory multicenter, non-interventional, translational, retrospective and prospective study. All patients with a diagnosis of hematologic disorder or malignancy for whom biological samples and clinical data are available may be included in this study, after obtaining informed consent

Detailed Description: Hematological malignancies account for approximately 9.5% of newly diagnosed cancers every year and their incidence shows an exponential rise after the age of 40. Since life expectancy is dramatically and continuously increasing worldwide, hematological diseases promise to become a substantial burden for the health care systems of the European society. The management of hematological malignancies is further complicated by the high level of disease heterogeneity in terms of pathogenic and molecular mechanisms. Due to the high level of heterogeneity in terms of cytogenetic, genetic, epigenetic, transcriptional, post-transcriptional and metabolic alterations, an accurate molecular classification of hematological diseases is needed to improve clinical outcomes and patients' management. This is an exploratory multicenter, non-interventional, translational, retrospective and prospective study. All patients with a diagnosis of hematologic disorder or malignancy for whom biological samples and clinical data are available may be included in this study, after obtaining informed consent. The primary objective is to improve our knowledge of the pathogenic mechanisms driving malignant disorders and transformation. The secondary objectives aim to improve diagnosis and stratification of onco-hematological patients and study drug response at preclinical level. After signing informed consent to the study, each patient will donate part of the samples (peripheral blood, bone marrow, biopsies) collected as per routine clinical practice for the management of their disease.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Irst Irccs, Meldola, FC, Italy

AOU Città della Salute e della scienza di Torino, Torino, TO, Italy

UO Hematology, Ospedale S. Maria delle Croci, Ravenna, , Italy

UO Hematology Ospedale Infermi, Rimini, , Italy

Ospedale Ca' Foncello Treviso, Treviso, , Italy

Contact Details

Name: Giovanni Martinelli, Prof

Affiliation: IRST IRCCS

Role: STUDY_DIRECTOR

Name: Alessandro Lucchesi, MD

Affiliation: IRST IRCCS

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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