The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.
Brief Title: A Phase I, Dose-escalation Study of AS703569 Given Orally to Subjects With Haematological Malignancies
Official Title: A Phase I, Dose-escalation Study of AS703569 Given Orally to Subjects With Haematological Malignancies
Study ID: NCT01080664
Brief Summary: EMD Serono decided to terminate enrollment based on a review of the available clinical data and low probability of completing the trial based on the observed recruitment rate. Subjects already enrolled in the study continued participation in the study, consistent with the protocol, to study completion.
Detailed Description: The goal of this research study is to investigate for the first time the safety and tolerability of a new drug (AS703569), called an aurora kinase inhibitor, being tested to treat blood cancers in patients with different blood cancers. The research study will also assess how the body breaks down AS703569 and what changes occur in the blood after oral doses of AS703569. It will also look to see if there is any improvement in your blood cancer. The use of AS703569 in this study is experimental.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
CTRC at the UT Health Science Center at San Antonio, San Antonio, Texas, United States
Haematologie UZ Gasthuisberg, Leuven, , Belgium
Mont-Godinne University Hospital (UCL), Yvoir, , Belgium
Universitatsklinik Frankfurt, Frankfurt am Main, , Germany
Technische Universitat Munchen, Munchen, , Germany
Medizinische Universitatsklinik, Ulm, , Germany
Policlinico Sant'Orsola Malpighi, Bologna, , Italy
Kantonsspital Basel, Basel, , Switzerland
Hospitaux Universitaires, Geneva, , Switzerland
Kantonsspital St Gallen, St Gallen, , Switzerland
Name: Narmyn Rejeb, M.D.
Affiliation: Merck Serono S.A., Geneva
Role: STUDY_DIRECTOR