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Brief Title: Study to Evaluate CCS1477 in Haematological Malignancies
Official Title: An Open-label Phase I/IIa Study to Evaluate the Safety and Efficacy of CCS1477 as Monotherapy and in Combination in Patients With Advanced Haematological Malignancies.
Study ID: NCT04068597
Brief Summary: A Phase 1/2a study to assess the safety, tolerability, PK and biological activity of CCS1477 in patients with Non-Hodgkin Lymphoma, Multiple Myeloma, Acute Myeloid Leukaemia or High Risk Myelodysplastic syndrome.
Detailed Description: This includes patients with Peripheral T-cell lymphoma.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Mayo Clinic, Phoenix, Arizona, United States
Institute Bergonie, Bordeaux, , France
Institute Gustave Roussy, Villejuif, , France
University Hospital Vall D'Hebron, Barcelona, , Spain
CIOCC Hospital Universitario HM Sanchinarro, Madrid, , Spain
Karolinska Institute, Stockholm, , Sweden
The Royal Marsden, Sutton, Surrey, United Kingdom
University Hospital of Wales, Cardiff, , United Kingdom
Western General Hospital, Edinburgh, , United Kingdom
Gartnavel General Hospital, Glasgow, , United Kingdom
Leicester Royal Infirmary, Leicester, , United Kingdom
NIHR University College London Clinical Research Facility, London, , United Kingdom
The Christie Hospital, Manchester, , United Kingdom
Cancer and Haematology Centre, Oxford, , United Kingdom
University Hospital of Southampton, Southampton, , United Kingdom
Name: Tim Somervaille
Affiliation: The Christie NHS Foundation Trust
Role: PRINCIPAL_INVESTIGATOR