Spots Global Cancer Trial Database for Reirradiation and Erbitux in the HNSCC
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Trial Identification
Brief Title: Reirradiation and Erbitux in the HNSCC
Official Title: A Phase II Study, Multicenter, to Evaluate the Efficacy and Safety of the Combination of Reirradiation - Erbitux in Subjects Previously Irradiated and With a Local Recurrent Inoperable Squamous Cell Cancer of the Head and Neck
Study ID: NCT01237483
Conditions
Interventions
Study Description
Brief Summary: The purpose of this study is to investigate in patients with cancer of the throat and recurrent inoperable a different modality treatment consisting of radiation continuously for 5 weeks and half associated with a drug directed against a receptor on cell surfaces cancer, called Erbitux ®. The investigators hope with this shorter treatment (1.5 weeks less than the usual treatment) to improve the antitumor efficacy without additional toxic side effects.
Detailed Description: We hope with this treatment improved antitumor efficacy without additional toxic side effects, while being shorter than 1.5 weeks of standard therapy. But this is an hypothesis we can not meet the current state of knowledge, which justifies this study. The main hypothesis is that this combination of reirradiation and Cetuximab give a relative gain of 15% complete response rate.
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Hôpital Bretonneau, Tours Cedex 09, , France
Contact Details
Name: Laurent MARTIN, oncologist
Affiliation: Centre Guillaume Le Conquérant, 76600 Le Havre, France
Role: STUDY_DIRECTOR
Name: Claude TUCHAIS, oncologist
Affiliation: Centre Paul Papin, 49933 Angers, France
Role: PRINCIPAL_INVESTIGATOR
Name: Sauveur Marc ALFONSI, oncologist
Affiliation: Institut Sainte Catherine, 84082 Avignon, France
Role: PRINCIPAL_INVESTIGATOR
Name: Xu Sh SUN, oncologist
Affiliation: Hôpital Jean Minoz, 25030 Besançon, France
Role: PRINCIPAL_INVESTIGATOR
Name: Dominique DE RAUCOURT, oncologist
Affiliation: Centre François Baclesse, 14076 Caen, France
Role: PRINCIPAL_INVESTIGATOR
Name: Michel LAPEYRE, oncologist
Affiliation: Centre Jean Perrin, 63011 Clermond-Ferrand, France
Role: PRINCIPAL_INVESTIGATOR
Name: Philippe MAINGON, oncologist
Affiliation: Centre G-F Leclerc, 21079 Dijon, France
Role: PRINCIPAL_INVESTIGATOR
Name: Muriel GARCIA-RAMIREZ, oncologist
Affiliation: Hôpital Robert Boulin, 33505 Libourne, France
Role: PRINCIPAL_INVESTIGATOR
Name: Christian SIRE, oncologist
Affiliation: Hôpital du Scorff, 56322 Lorient, France
Role: PRINCIPAL_INVESTIGATOR
Name: Séverine RACADOT, oncologist
Affiliation: Centre Léon Bérard, 69373 Lyon, France
Role: PRINCIPAL_INVESTIGATOR
Name: Véronique FAVREL, oncologist
Affiliation: Centre Hospitalier Lyon Sud, 69495 Pierre-Benite, France
Role: PRINCIPAL_INVESTIGATOR
Name: Etienne BARDET, oncologist
Affiliation: Centre René Gauducheau, 44805 Nantes-St Herblain, France
Role: PRINCIPAL_INVESTIGATOR
Name: Philippe LANG, oncologist
Affiliation: Hôpital de La Pitié Salpitrière, 75013 Paris, France
Role: PRINCIPAL_INVESTIGATOR
Name: Isabelle TENNEVET, oncologist
Affiliation: Centre Henri Becquerel, 76038 Rouen, France
Role: PRINCIPAL_INVESTIGATOR
Name: Patricia BURBAN, oncologist
Affiliation: Clinique Armoricaine de Radiologie, 22015 St Brieuc, France
Role: PRINCIPAL_INVESTIGATOR
Name: Olivier GALLOCHER, oncologist
Affiliation: Clinique Pasteur, 31300 Toulouse, France
Role: PRINCIPAL_INVESTIGATOR
Name: Olivier GALLOCHER, oncologist
Affiliation: Polyclinique du Parc, 31078 Toulouse, France
Role: PRINCIPAL_INVESTIGATOR
Name: Yungan TAO, oncologist
Affiliation: Institut Gustave Roussy, 94805 Villejuif, France
Role: PRINCIPAL_INVESTIGATOR
Name: Pierre BOISSELIER, oncologist
Affiliation: Val d'Aurelle 34298 Montpellier cedex
Role: PRINCIPAL_INVESTIGATOR
Name: Frédéric PEYRADE, oncologist
Affiliation: Centre Antoine Lacassagne 06189 NICE cedex 2
Role: PRINCIPAL_INVESTIGATOR
Name: Marie SALIOU, oncologist
Affiliation: Clinique de l' Estuaire 44600 Pornichet
Role: PRINCIPAL_INVESTIGATOR
Name: Cédrik LAFOND, oncologist
Affiliation: Centre Jean Bernard 72000 Le Mans
Role: PRINCIPAL_INVESTIGATOR
Name: René-Jean BENSADOUN, oncologist
Affiliation: CHU 86021 Poitiers cedex
Role: PRINCIPAL_INVESTIGATOR
Name: Alexandre COUTTE, oncologist
Affiliation: CHU Amiens sud 80004 Amiens
Role: PRINCIPAL_INVESTIGATOR
Name: Hao QIU, oncologist
Affiliation: CHU 86000 Limoges
Role: PRINCIPAL_INVESTIGATOR
Name: Florence HUGUET, oncologist
Affiliation: Hôpital Tenon 75020 Paris
Role: PRINCIPAL_INVESTIGATOR
Name: Sébastien GUIHARD
Affiliation: Centre Paul Strauss 67065 Strasbourg
Role: PRINCIPAL_INVESTIGATOR
Name: Xu Shan SUN, oncologist
Affiliation: Centre Hospitalier de Belfort Montbéliard Bd du Maréchal Juin 25200 Montbéliard
Role: PRINCIPAL_INVESTIGATOR
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