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Spots Global Cancer Trial Database for Predicting Radiological Extranodal Extension in Oropharyngeal Carcinoma Patients Using AI

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Trial Identification

Brief Title: Predicting Radiological Extranodal Extension in Oropharyngeal Carcinoma Patients Using AI

Official Title: Predicting Radiological Extranodal Extension in Oropharyngeal Carcinoma Patients Using AI

Study ID: NCT05565313

Interventions

Study Description

Brief Summary: Development and validation of a model that predicts rENE from radiological imaging using annotated / labeled scans by means of deep learning

Detailed Description: Oropharyngeal squamous cell carcinoma (OPSCC) is a rare cancer (incidence \~700 per year in the Netherlands), originating in the middle part of the throat. In OPSCC, nodal status is an important prognostic factor for survival. In the clinical TNM (tumor node metastases) system, nodal status is mainly defined by the size, number and laterality of nodal metastases. In surgically treated patients the pathological TNM classification includes the presence of pathological extranodal extension (pENE). pENE is a predictor for poor outcome and also an indication for the addition of chemotherapy to postoperative radiation. However, most patients with OPSCC are treated non-surgically by means of radiation or chemoradiation and thus information about pENE is lacking. Recently, extranodal extension on diagnostic imaging has been associated with prognosis in OPSCC patients. It is anticipated that in the near future radiological ENE (rENE) may be included in the cTNM classification system for refinement of outcome prediction in patients with nodal disease. The diagnosis of rENE on radiological imaging is new and not trivial and we hypothesize that Artificial Intelligence (AI) may support the radiologist in detecting rENE. In this study we aim to develop and validate a model that predicts rENE from radiological imaging using annotated / labeled scans by means of deep learning

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Harvard Medical School and clinical faculty at Dana-Farber Cancer Institute/Brigham and Women's Hospital, Boston, Massachusetts, United States

Princess Margaret Cancer Centre, Toronto, Ontario, Canada

Maastro, Maastricht, Limburg, Netherlands

Contact Details

Name: Frank Hoebers, PhD

Affiliation: Maastro

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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