Spots Global Cancer Trial Database for Ascertaining the Radiologic Prognostic Importance of Extranodal Extension on Imaging (iENE) in Head and Neck Cancer
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Trial Identification
Brief Title: Ascertaining the Radiologic Prognostic Importance of Extranodal Extension on Imaging (iENE) in Head and Neck Cancer
Official Title: Ascertaining the Radiologic Prognostic Importance of Extranodal Extension on Imaging (iENE) in Head and Neck Cancer Part of the Evaluation Prognostic and Predictive Indicators in Head and Neck Cancer (EPIC) Programme, Run Under the Auspices of the Head and Neck Inter Group (HNCIG, Www.Hncig.Org)
Study ID: NCT05936502
Interventions
Study Description
Brief Summary: Extranodal extension (ENE) refers to the spread of head and neck squamous cell carcinoma (HNSCC) outside the lymph nodes. It is a well-known factor that indicates a poorer prognosis and outcome for patients who have undergone surgical removal of the cancer. In such cases, it is recommended to combine chemotherapy with radiation therapy after surgery. As the number of cases of HNSCC related to the human papillomavirus (HPV) is increasing, treatment approaches have shifted towards using radiation therapy as the primary treatment method instead of surgery. This raises an important question about the significance of ENE observed through imaging tests (referred to as iENE) and its impact on the prognosis. Unfortunately, this question remains unanswered. The objective of this project is to conduct a comprehensive study across multiple medical institutions. The investigators will gather data including scan results, histopathology reports, and data from patient charts from individuals who have been treated for head and neck cancer. The aim is to analyze and correlate the findings between the pathological evidence of ENE and the imaging results, while also assessing the prognostic value of iENE. Additionally, the investigators will explore the influence of HPV status on these factors. By collecting and analyzing this data, the investigators hope to establish standardized criteria that can assist radiologists in accurately identifying ENE through imaging tests. This research is essential for enhancing our understanding of HNSCC and improving the effectiveness of diagnostic procedures and treatment planning.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Methodist Estabrook Cancer Center, Omaha, Nebraska, United States
Mount Sinai Health System, New York, New York, United States
University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States
Royal Adelaide Hospital, Adelaide, , Australia
Copenhagen University Hospitals, Copenhagen, , Denmark
Georges Pompidou European Hospital, Paris, , France
University of Cologne, Cologne, , Germany
Technical University of Munich, Munich, , Germany
Catalan Institute of Oncology, Barcelona, , Spain
University Hospital Zürich, Zürich, , Switzerland
University Hospitals Birmingham, Birmingham, , United Kingdom
Leeds Teaching Hospitals NHS Trust, Leeds, , United Kingdom
Contact Details
Name: Hisham Mehanna, PhD
Affiliation: University of Birmingham
Role: PRINCIPAL_INVESTIGATOR
Name: Christina Henson, MD
Affiliation: The University of Oklahoma Health Sciences Center
Role: PRINCIPAL_INVESTIGATOR
Name: Ahmad K. Abou-Foul, MD
Affiliation: University of Birmingham
Role: PRINCIPAL_INVESTIGATOR
Name: Paul C Nankivell, PhD
Affiliation: University of Birmingham
Role: PRINCIPAL_INVESTIGATOR
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