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Spots Global Cancer Trial Database for Pirfenidone as a Radiosensitizer in the Treatment of Head and Neck Squamous Cell Carcinoma

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Trial Identification

Brief Title: Pirfenidone as a Radiosensitizer in the Treatment of Head and Neck Squamous Cell Carcinoma

Official Title: Application of Pirfenidone as a Radiosensitizer in the Treatment of Head and Neck Squamous Cell Carcinoma: Phase II Clinical Study

Study ID: NCT06142318

Interventions

Pirfenidone
Placebo

Study Description

Brief Summary: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide, with a 5-year survival rate of less than 50%. Radiotherapy is an important measure to control tumor recurrence. Although radiotherapy has been widely used in patients with head and neck squamous cell carcinoma, the 2-year local recurrence rate of patients with locally advanced disease is still as high as 50%-60%, and the distant metastasis rate is as high as 20%-30%. This is associated with a lower radiosensitivity in HNSCC. Our previous study has confirmed that type I collagen secreted by cancer-associated fibroblasts (CAFs) can enhance the radioresistance of head and neck squamous cell carcinoma. We also confirmed that pirfenidone could reduce type I collagen expression in CAFs and enhance radiosensitivity in vitro and in vivo. Therefore, we plan to translate the basic research into clinical practice and conduct a prospective interventional phase II clinical trial to investigate the safety and efficacy of pirfenidone as a radiosensitizer in HNSCC.

Detailed Description:

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Southern medical university, Guangzhou, Guangdong, China

Fujian Provinical Hospital, Fuzhou, , China

Huizhou Central People's Hospital, Huizhou, , China

Jieyang people's hospital, Jieyang, , China

Meizhou People's Hospital, Meizhou Academy of Medical Sciences Meizhou, Meizhou, , China

Contact Details

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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