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Brief Title: DAHANCA 27 Transoral Laser Microsurgery for T1a Glottic Cancer
Official Title: DAHANCA 27 Transoral Laser Microsurgery for T1a Glottic Cancer
Study ID: NCT05289336
Brief Summary: To evaluate whether Transoral Laser Microsurgery (TLM) is non-inferior compared to Accelerated Radiotherapy (accRT) in the treatment of T1aN0M0 glottic SCC
Detailed Description: Since 2003 the Danish national standard treatment for T1aN0M0 glottic SCC has been accelerated RT (66Gy. 2 GY/fraction, 6 fractions/week). In 2012 cordectomy type I-III using TLM was introduced as an experimental treatment. The DAHANCA 27 trial is a comparative non-inferiority phase II study comparing two timely separated national patient cohorts. Patients treated with radical TLM from September 2012 to April 2016 were included in the TLM cohort, and patients treated with accelerated RT from January 2003 to august 2012 were included in the RT cohort
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Aalborg University Hospital, Aalborg, , Denmark
Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, , Denmark
Aarhus University Hospital, Aarhus, , Denmark
Rigshospitalet, Copenhagen, , Denmark
Odense University Hospital, Odense, , Denmark
Name: Nina M Lyhne, MD
Affiliation: Aalborg University Hospital, Denmark
Role: STUDY_CHAIR