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Spots Global Cancer Trial Database for DAHANCA 27 Transoral Laser Microsurgery for T1a Glottic Cancer

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Trial Identification

Brief Title: DAHANCA 27 Transoral Laser Microsurgery for T1a Glottic Cancer

Official Title: DAHANCA 27 Transoral Laser Microsurgery for T1a Glottic Cancer

Study ID: NCT05289336

Study Description

Brief Summary: To evaluate whether Transoral Laser Microsurgery (TLM) is non-inferior compared to Accelerated Radiotherapy (accRT) in the treatment of T1aN0M0 glottic SCC

Detailed Description: Since 2003 the Danish national standard treatment for T1aN0M0 glottic SCC has been accelerated RT (66Gy. 2 GY/fraction, 6 fractions/week). In 2012 cordectomy type I-III using TLM was introduced as an experimental treatment. The DAHANCA 27 trial is a comparative non-inferiority phase II study comparing two timely separated national patient cohorts. Patients treated with radical TLM from September 2012 to April 2016 were included in the TLM cohort, and patients treated with accelerated RT from January 2003 to august 2012 were included in the RT cohort

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Aalborg University Hospital, Aalborg, , Denmark

Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, , Denmark

Aarhus University Hospital, Aarhus, , Denmark

Rigshospitalet, Copenhagen, , Denmark

Odense University Hospital, Odense, , Denmark

Contact Details

Name: Nina M Lyhne, MD

Affiliation: Aalborg University Hospital, Denmark

Role: STUDY_CHAIR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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