Spots Global Cancer Trial Database for PF-00299804 in Patients With Head and Neck Squamous Cell Carcinoma
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Trial Identification
Brief Title: PF-00299804 in Patients With Head and Neck Squamous Cell Carcinoma
Official Title: Phase II Trial of PF-00299804 in Patients With Metastatic/Recurrent Head and Neck Squamous Cell Carcinoma (HNSCC) After Failure of Platinum-containing Therapy
Study ID: NCT01449201
Interventions
Study Description
Brief Summary: Epidermal growth factor receptor (EGFR) is often over-expressed, and have been related to poor prognosis in patients with HNSCC. EGFR targeting strategies showed clinical anti-tumor efficacy in patients with HNSCC. PF-00299804 is a second-generation quinazoline-based irreversible pan-HER inhibitor. In preclinical studies, PF-00299804 has much lower IC50 values than gefitinib in cell lines engineered to express EGFRvIII mutations (1.2 nM versus 2,700 nM) and produces tumor growth inhibition in gefitinib-resistant xenografts. A phase II trial of PF-00299804 in patients with recurrent or metastatic HNSCC is currently ongoing and preliminary report in ASCO 2010 showed its anti-tumor activity against HNSCC. The investigators suggest a phase II trial of pan-HER inhibitor PF-00299804 in patients with recurrent or metastatic HNSCC previously treated with platinum-based chemotherapy.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Chilgok Kyungpook National University Hospital, Daegu, , Korea, Republic of
Dongsan Medical Center, Daegu, , Korea, Republic of
Severance Hospital, Seoul, , Korea, Republic of
Asan Medical Center, Seoul, , Korea, Republic of
Samsung Medical Center, Seoul, , Korea, Republic of
Seoul National University Hospital Cancer Center, Seoul, , Korea, Republic of
Contact Details
Name: Byoung Chul Cho, M.D.,Ph.D.
Affiliation: Yonsei University
Role: PRINCIPAL_INVESTIGATOR
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