Spots Global Cancer Trial Database for Spermidine Intake and All-cause Mortality

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Trial Identification

Brief Title: Spermidine Intake and All-cause Mortality

Official Title: Association Between Dietary Spermidine Intake and Mortality in the Population-based Bruneck Study

Study ID: NCT03378843

Conditions

Healthy Diet

Mortality

Interventions

Spermidine content of natural diet

Study Description

Brief Summary: This study seeks to test the potential association between spermidine content in diet and mortality in humans.

Detailed Description: This prospective community-based cohort study includes 829 participants aged 45-84 years, 49.9% of which are male. Diet is assessed by repeated dietician-administered validated food-frequency questionnaires (2540 assessments) in 1995, 2000, 2005, and 2010. Nutrient intakes including spermidine are calculated using USDA standard databases. Clinical events (all-cause mortality and cause-specific mortality) are recorded from 1995 to 2015. The primary endpoint of all-cause mortality is related to the exposure of long-term average spermidine intake by Cox proportional hazards models with time-varying covariates. Additional analyses employ the Fine and Gray proportional subdistribution hazards model and flexible Royston-Parmar spline-based models. Comprehensive sensitivity analyses are performed to guard against potential biases associated with nutritional epidemiology.