Spots Global Cancer Trial Database for Construction and Evaluation of the Liquid Biopsy-based Early Diagnostic Model for Lung Cancer
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Trial Identification
Brief Title: Construction and Evaluation of the Liquid Biopsy-based Early Diagnostic Model for Lung Cancer
Official Title: Construction and Evaluation of the Liquid Biopsy-based Early Diagnostic Model for Lung Cancer
Study ID: NCT04156360
Interventions
Study Description
Brief Summary: The purpose of this study is to detetct Circulating tumor cells(CTCs) and Cancer Associated Macrophage-Like cells (CAMLs) in patients with pulmonary nodules using a novel microfluidic CTC-detection system. Then construct an early diagnostic model for lung cancer.
Detailed Description: Patients found pulmonary nodules by CT screening will be enrolled in this study prospectively. CTCs and CAMLs both are cancer specific biomarkers found in the peripheral blood of patients with solid tumors including lung cancer. Through detecting CTCs and CAMLs in healthy volunteers and patients with pulmonary nodules who undergo biopsy, determine the cut-off value of the test. Further analysis of the test specificity and sensitivity, and on this basis construct an early diagnostic model for lung cancer.
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: Yes
Locations
Contact Details
Name: Yayi He, MD, PHD
Affiliation: Shanghai Pulmonary Hospital, Tongji University
Role: PRINCIPAL_INVESTIGATOR
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