Spots Global Cancer Trial Database for Prevention of Heart Failure Induced by Doxorubicin With Early Administration of Dexrazoxane
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Trial Identification
Brief Title: Prevention of Heart Failure Induced by Doxorubicin With Early Administration of Dexrazoxane
Official Title: Prevention of Heart Failure Induced by Doxorubicin With Early Administration of Dexrazoxane in Patients With Breast Cancer
Study ID: NCT03930680
Conditions
Interventions
Study Description
Brief Summary: The purpose of this research study is to determine whether early administration of Dexrazoxane prevents Doxorubicin induced cardiotoxicity.
Detailed Description: This is a study on volunteers to determine effective dose of dexrazoxane in degrading Topoisomerase 2 b in human blood samples. Each participant will receive one dose of dexrazoxane. Blood samples will be collected to determine the time course and degradation of Topoisomerase 2b and Topoisomerase 2a
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: FEMALE
Healthy Volunteers: Yes
Locations
University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States
Contact Details
Name: Hui-Ming Chang, MD,MPH
Affiliation: University of Arkansas
Role: PRINCIPAL_INVESTIGATOR
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