Spots Global Cancer Trial Database for To Evaluate the Effects of Omega 3 Fatty Acids in the Context of Cancer Prevention

Study Description

Brief Summary: Previous studies have demonstrated, in an in vitro micro-tumour model (the spheroid) and in a mouse model, that long-chain omega-3 fatty acids, in particular docosahexaenoic acid (DHA), can inhibit tumour development. Therefore, the aim of this study was to collect DHA-enriched human serum, following ingestion of a DHA-enriched oil, in order to assess its effect on tumour development in vitro. Blood enriched in fatty acids not containing DHA will be used as a control condition, obtained after ingestion of olive oil. This study is an important step to determine the interest of DHA supplementation as a new approach to prevent tumour development, and/or as an adjuvant to cancer treatments.

Detailed Description: The objective of this study is to collect DHA-enriched human serum in order to test it on the in vitro tumour model, spheroids. The results will be compared with human serum enriched in fatty acids (saturated, monounsaturated and polyunsaturated) but not in DHA. To do this, the study will be divided into 4 steps 1. determination of the time when a maximum concentration of fatty acids is observed in the serum after ingestion of olive oil (the control condition) 2. blood sampling at baseline (fasting) and at Tmax after olive oil ingestion 3. determination of the time when a maximum concentration of fatty acids is observed in the serum after ingestion of DHA-enriched oil (the test condition) 4. blood sampling at baseline (fasting) and at Tmax after ingestion of DHA-enriched oil.

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: Yes

Locations

Contact Details

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