Spots Global Cancer Trial Database for A Phase II Single-arm Study of Total Body Irradiation With Linac Based VMAT and IGRT

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Trial Identification

Brief Title: A Phase II Single-arm Study of Total Body Irradiation With Linac Based VMAT and IGRT

Official Title: A Phase II Single-Arm Study of Total Body Irradiation With Linac Based Volumetric Modulated Arc Therapy (VMAT) and Image Guided Radiation Therapy (IGRT)

Study ID: NCT04509765

Conditions

Hematologic Malignancy

Interventions

Linac Based VMAT TBI

Study Description

Brief Summary: Single institution study of safety of linac based VMAT TBI for myeloablative treatment in hematologic malignancies.

Detailed Description: Total Body Irradiation (TBI) continues to play an important role in myeloablative and non-myeloablative conditioning regimens for Allogeneic Stem Cell Transplant (ASCT). When TBI is used as part of a myeloablative regimen, it is combined with chemotherapy to eradicate malignant cells, as well as to immunosuppress the host to prevent rejection of donor hematopoietic progenitor cells (HPC). This study is a single-institution study to assess the safety of linac based VMAT TBI for myeablative sreatment in hematologic malignancies.