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Brief Title: Dose-range Finding Treosulfan-based Conditioning
Official Title: Allogeneic Hematopoietic Stem Cell Transplantation in Patients With Advanced Hematological Malignancies After Treosulfan-based Conditioning Therapy - A Clinical Phase II Study
Study ID: NCT01063647
Brief Summary: Evaluation of the safety and efficacy of 3 x 10, 3 x 12 or 3 x 14 g/m² Treosulfan resp., combined with 5 x 30 mg/m² fludarabine prior to allogeneic, hematopoietic stem cell transplantation of patients with hematological malignancies, but non-eligible to standard conditioning treatment.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Helsinki University Central Hospital, Helsinki, , Finland
Charité University Hospital Berlin, Berlin, , Germany
University Hospital Hamburg Eppendorf, Hamburg, , Germany
5th Medical Clinic, Clinic North, Nuremberg, , Germany
University Hospital Rostock, Rostock, , Germany
Silesian Medical University, Katowice, , Poland
Karolinska University Hospital & Karolinska Institute, Stockholm, , Sweden
Name: Mathias Freund, MD
Affiliation: University Hospital Rostock
Role: PRINCIPAL_INVESTIGATOR