Spots Global Cancer Trial Database for CAR-T Cellular Therapy for B Cell Malignancies Involved in CNS
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Trial Identification
Brief Title: CAR-T Cellular Therapy for B Cell Malignancies Involved in CNS
Official Title: CAR-T Cellular Therapy for B Cell Malignancies Involved in Central Nervous System
Study ID: NCT04287309
Conditions
Interventions
Study Description
Brief Summary: This is a single arm, open-label, single-center study. This study is indicated for relapsed or refractory CD19+ B-line hematological malignancy involved in CNS. 20 patients were enrolled. Primary objective is to explore the safety. The secondary objective is to explore the efficacy.
Detailed Description: This is a single arm, open-label, single-center study. This study is indicated for relapsed or refractory CD19+ B-line hematological malignancy involved in CNS. All together 20 patients were enrolled. Primary objective is to explore the safety including the complication of cytokine release syndrome, CRES, pancytopenia and infection. The secondary objective is to explore the efficacy. We will also detect CAR-T cell expansion dynamics in blood and cerebral fluid and compare the difference.
Keywords
Eligibility
Minimum Age: 3 Years
Eligible Ages: CHILD, ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
The First Hospital of Zhejiang Medical Colleage Zhejiang University, Hangzhou, Zhejiang, China
the First Affiliated Hospital,School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
Contact Details
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