Spots Global Cancer Trial Database for Liver and Fat Regulation in Overweight Adolescent Girls

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Trial Identification

Brief Title: Liver and Fat Regulation in Overweight Adolescent Girls

Official Title: Assessment of Hepatic Glucose and Fat Regulation in Overweight Adolescent Girls

Study ID: NCT02157974

Conditions

Hepatic Steatosis

Polycystic Ovarian Syndrome

Obesity

Interventions

Byetta 5Mcg Pen Injection

Study Description

Brief Summary: Women with polycystic ovarian syndrome (PCOS) have increased rates of hepatic steatosis compared to weight similar women with regular menses. It is unclear if this is related to high testosterone or insulin resistance. The investigators will assess hepatic glucose release, rates of lipolysis and hepatic de novo lipogenesis in the fasted and postprandial state to determine if alterations in the processes contribute to hepatic steatosis. Participants will be overweight, sedentary girls with or without PCOS. Those with PCOS will either be medication naive, or must be taking metformin or combined oral contraceptives (COCPs) for a period of at least 6 months prior to study procedures.

Detailed Description: Hepatic glucose release will be assessed with a stable isotope glycerol tracer, lipolysis with a glycerol tracer, and hepatic de novo lipogenesis with an acetate tracer. Data will be collected fasting and after a glucose challenge. The degree of hepatic steatosis and abdominal fat partitioning will be assessed with Magnetic Resonance Imaging (MRI), and total body composition with Dual-energy X-ray absorptiometry (DEXA).