Spots Global Cancer Trial Database for Assessment of Hepatitis B Virus Intra-host Population and Host-specific Immune Marker Diversity

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Trial Identification

Brief Title: Assessment of Hepatitis B Virus Intra-host Population and Host-specific Immune Marker Diversity

Official Title: Assessment of Hepatitis B Virus Intra-host Population and Host-specific Immune Marker Diversity With Next-generation Sequencing: From Chronic Infection to End-stage Liver Disease and Liver Cancer

Study ID: NCT02148562

Conditions

Hepatitis B

Hepatitis B, Chronic

End Stage Liver Disease

Carcinoma, Hepatocellular

Interventions

Study Description

Brief Summary: In this project proposal, the investigators will investigate the genetic alterations of Hepatitis B Virus (HBV) strains circulating in Belgian patients who developed end stage liver disease. Additionally, the investigators will compare and link these data sets with three genetic factors involved in immune system response.

Detailed Description: This project proposes to identify and characterize the genetic alterations associated with intra-host evolution of HBV from a chronically infection status to an end-stage liver disease status.