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Spots Global Cancer Trial Database for A US Study to Evaluate Transarterial Radioembolization (TARE) in Combination With Durvalumab and Bevacizumab Therapy in People With Unresectable Hepatocellular Carcinoma Amenable to TARE

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Trial Identification

Brief Title: A US Study to Evaluate Transarterial Radioembolization (TARE) in Combination With Durvalumab and Bevacizumab Therapy in People With Unresectable Hepatocellular Carcinoma Amenable to TARE

Official Title: Phase II Single-Arm Study of Durvalumab and Bevacizumab Following Transarterial Radioembolization Using Yttrium-90 Glass Microspheres (TheraSphere™) in Unresectable Hepatocellular Carcinoma Amenable to Locoregional Therapy

Study ID: NCT06040099

Study Description

Brief Summary: The purpose of this study is to measure the efficacy and safety of durvalumab intravenous (IV) solution plus bevacizumab IV solution after transarterial radioembolization (Yttrium 90 glass microspheres TARE) in participants with unresectable hepatocellular carcinoma (HCC) amenable to embolization.

Detailed Description: A Phase II single-arm study conducted in participants with unresectable Hepatocellular carcinoma (HCC) eligible for embolization and not eligible for or who have declined treatment with resection and/or ablation or liver transplant. Participants with previous Transarterial Chemoembolization (TACE) or TARE associated with the curative setting are permitted with a 6-month washout. Approximately 125 participants with unresectable but amenable to locoregional therapy HCC eligible for embolization will be enrolled in the study at approximately 20 sites in the US to treat approximately 100 participants.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Research Site, Aurora, Colorado, United States

Research Site, Gainesville, Florida, United States

Research Site, Miami, Florida, United States

Research Site, Orlando, Florida, United States

Research Site, Atlanta, Georgia, United States

Research Site, Boston, Massachusetts, United States

Research Site, Detroit, Michigan, United States

Research Site, Saint Louis, Missouri, United States

Research Site, Trenton, New Jersey, United States

Research Site, Buffalo, New York, United States

Research Site, New York, New York, United States

Research Site, Rochester, New York, United States

Research Site, Chapel Hill, North Carolina, United States

Research Site, Columbus, Ohio, United States

Research Site, Portland, Oregon, United States

Research Site, Philadelphia, Pennsylvania, United States

Research Site, Charlottesville, Virginia, United States

Research Site, Fairfax, Virginia, United States

Research Site, Seattle, Washington, United States

Research Site, Milwaukee, Wisconsin, United States

Research Site, Milwaukee, Wisconsin, United States

Contact Details

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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