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Brief Title: Study of BGB-A317 in Participants With Previously Treated Unresectable HCC
Official Title: A Phase 2, Open-label, Multicenter Study to Investigate the Efficacy, Safety, and Pharmacokinetics of the Anti-PD-1 Monoclonal Antibody BGB-A317 in Patients With Previously Treated Hepatocellular Unresectable Carcinoma
Study ID: NCT03419897
Brief Summary: This study investigated the efficacy, safety, and pharmacokinetics of the anti-PD-1 monoclonal antibody BGB-A317 in participants with previously treated hepatocellular unresectable carcinoma.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Anhui Provincial Hospital, Hefei, Anhui, China
The Second Hospital of Anhui Medical Hospital, Hefei, Anhui, China
302 Military Hospital of China, Beijing, Beijing, China
Beijing Cancer Hospital, Beijing, Beijing, China
Cancer Hospital Chinese Academy of Medical Sciences, Beijing, Beijing, China
Fujian Medical University Union Hospital, Fuzhou, Fujian, China
Sun Yat-Sen Memorial Hospital,Sun Yat-Sen University, Guangzhou, Guangdong, China
Nanfang Hospital of Southern Medical University, Guangzhou, Guangdong, China
Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, China
Henan Cancer Hospital, Zhengzhou, Henan, China
Union Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan, Hubei, China
Hubei Cancer Hospital, Wuhan, Hubei, China
Xuzhou Central Hospital, Xuzhou, Jiangsu, China
The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China
The First affiliated hospital of Nanchang University, Nanchang, Jiangxi, China
Jilin Cancer Hospital, Changchun, Jilin, China
The First Hospital of Jilin University, Changchun, Jilin, China
Weifang People's Hospital, Weifang, Shandong, China
Shanghai Cancer Hospital, Fudan University, Shanghai, Shanghai, China
Zhongshan Hospital Fudan University, Shanghai, Shanghai, China
Tianjin Medical University Cancer Institute & Hospital, Tianjin, Tianjin, China
The First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China
The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, Zhejiang, China
Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China
The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
Chinese PLA General Hospital Medical School of Chinese PLA, Beijing, , China
CHU Nice - Hôpital de l'Archet 2, Nice Cedex 3, Alpes Maritimes, France
Groupe Hospitalier Sud - Hôpital Haut Lévêque, Pessac Cedex, Gironde, France
Hopital Saint Eloi, Montpellier, Herault, France
CRLCC Eugene Marquis, Rennes cedex, Ille Et Vilaine, France
Hopital Beaujon, Clichy, Paris, France
Centre Hospitalier de la Croix Rousse, Lyon, Rhone, France
Centre Hospitalier de la Croix Rousse, Lyon, Rhone, France
Institut Gustave Roussy, Villejuif cedex, Val De Marne, France
CHU Poitiers - Hôpital la Milétrie, Poitiers Cedex, Vienne, France
Kliniken Essen-Mitte, Essen, Nordrhein Westfalen, Germany
Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz, Rheinland Pflaz, Germany
Universitaetsklinikum Hamburg-Eppendorf, Hamburg, , Germany
Istituto Clinico Humanitas, Rozzano, Milano, Italy
Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII (Presidio Papa Giovanni XXIII), Bergamo, , Italy
Azienda Ospedaliero Universitaria Pisana, Pisa, , Italy
Università Campus Bio-Medico di Roma, Roma, , Italy
Centrum Badan Klinicznych Piotr Napora Lekarze Spolka Partnerska, Warszawa, , Poland
Centrum Onkologii-Instytut im. M. Sklodowskiej Curie, Wroclaw, , Poland
ICO l'Hospitalet - Hospital Duran i Reynals, L'Hospitalet de Llobregat, Barcelona, Spain
Hospital Universitari Vall d'Hebron, Barcelona, , Spain
Hospital Universitario Reina Sofia, Córdoba, , Spain
Hospital Universitario Ramón Y Cajal, Madrid, , Spain
Hospital Universitario La Paz, Madrid, , Spain
Hospital Universitario HM Madrid Sanchinarro, Madrid, , Spain
Chiayi Chang Gung Memorial Hospital of the Chang Gung Medical Foundation, Chiayi City, , Taiwan
E-Da Cancer Hospital, Kaohsiung, , Taiwan
Chang Gung Memorial Hospital, Kaohsiung, Kaohsiung, , Taiwan
National Cheng Kung University Hospital, Tainan, , Taiwan
National Taiwan University Hospital, Taipei, , Taiwan
Taipei Veterans General Hospital, Taipei, , Taiwan
Chang Gung Memorial Hospital, Linkou, Taoyuan, , Taiwan
The Christie NHS Foundation Trust, Manchester, England, United Kingdom
Royal Free Hospital, London, Greater London, United Kingdom
King's College Hospital, London, Greater London, United Kingdom
Beatson West of Scotland Cancer Centre, Glasgow, Strathclyde, United Kingdom
Queen Elizabeth Hospital, Birmingham, West Midlands, United Kingdom
Freeman Hospital, Newcastle Upon Tyne, , United Kingdom
Name: Study Director
Affiliation: BeiGene
Role: STUDY_DIRECTOR