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Spots Global Cancer Trial Database for Sorafenib and TACE as Adjuvant Therapy for MVI in HCC Patients After Radical Resection

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We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Sorafenib and TACE as Adjuvant Therapy for MVI in HCC Patients After Radical Resection

Official Title: Sorafenib and TACE as Adjuvant Therapy for MVI in HCC Patients After Radical Resection:a Non-randomized Controlled Trial

Study ID: NCT02537158

Interventions

Sorafenib
TACE

Study Description

Brief Summary: This study is a prospective non-randomized controlled study. The purpose of this study is to evaluate the validity and safety of sorafenib and transcatheter arterial chemoembolization (TACE) for microvascular invasion (MVI) in hepatocellular carcinoma (HCC) patients after radical surgery.

Detailed Description: HCC is the sixth most common malignancy worldwide.Selected patients with HCC are candidates for potentially curative therapy, such as hepatic resection and liver transplantation. Nevertheless,tumor recurrence is 70 % at 5 years after resection and 15-30 % after liver transplantation,leading to tumor-related death.MVI is currently one of the most critical factors predictive of HCC recurrence.There are no approved effective interventional measures to improve the outcome of this patients with MVI.The purpose of this study is to explore the validity and safety of sorafenib and TACE for MVI in HCC patients after radical resection.The candidates will be assigned to sorafenib group (about 30 cases),TACE group (about 30 patients) and control group (about 30 cases),according to the willingness of the subject.All patients will be followed up for 3 years and Recurrence-free survival and overall survival will be recorded.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Cancer Hospital and Institute, Chinese Academy of Medical Sciences, Bei jing, , China

Contact Details

Name: Xinyu Bi, Doctor

Affiliation: Cancer Hospital and Institute, Chinese Academy of Medical Sciences

Role: STUDY_DIRECTOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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