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Brief Title: Intra-tumor Injection of Drug-eluting Microspheres With Multiple Drugs
Official Title: Intra-tumor Injection of Drug-eluting Microspheres Loading With Chemodrug Plus Checkpoint Inhibitors and IL2 for Treatment of Advanced Solid Tumors
Study ID: NCT04770207
Brief Summary: To study the safety and clinical effect of injection of drug-eluting microspheres with multiple chemodrug and protein drugs into advanced solid tumors.
Detailed Description: Drug-eluting microspheres such as DC-beads will be loaded with IL2, PD1/PDL1/CTLA4 antibody, or /and VEGF/VEGFR antibody with or without doxorubicin/idarubicin for various time and injected into tumors under CT guidance. Side effects and treatment efficacy after injection of drug-eluting microspheres into malignant tumors will be assessed according to RICEST1.1 standard.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China
Name: Zhenfeng Zhang, MD, PhD
Affiliation: Second Affiliated Hospital of Guangzhou Medical University
Role: PRINCIPAL_INVESTIGATOR