Spots Global Cancer Trial Database for A Study of Nivolumab in Combination With Ipilimumab in Participants With Advanced Hepatocellular Carcinoma
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Trial Identification
Brief Title: A Study of Nivolumab in Combination With Ipilimumab in Participants With Advanced Hepatocellular Carcinoma
Official Title: A Randomized, Multi-center, Phase 3 Study of Nivolumab in Combination With Ipilimumab Compared to Sorafenib or Lenvatinib as First-Line Treatment in Participants With Advanced Hepatocellular Carcinoma
Study ID: NCT04039607
Conditions
Study Description
Brief Summary: The main purpose of this study is to compare the overall survival (OS) of nivolumab plus ipilimumab versus standard of care (SOC) (sorafenib or lenvatinib) in all randomized participants with advanced hepatocellular carcinoma (HCC) who have not received prior systemic therapy.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Local Institution - 0292, Tucson, Arizona, United States
Local Institution - 0288, Coronado, California, United States
Local Institution - 0157, Duarte, California, United States
Local Institution - 0077, Washington, District of Columbia, United States
Local Institution - 0027, Louisville, Kentucky, United States
Local Institution - 0190, Baltimore, Maryland, United States
Local Institution, Ann Arbor, Michigan, United States
Local Institution - 0018, Detroit, Michigan, United States
Local Institution - 0295, Newark, New Jersey, United States
Local Institution - 0043, Toledo, Ohio, United States
Local Institution - 0284, Pittsburgh, Pennsylvania, United States
Local Institution - 0304, Dallas, Texas, United States
Local Institution - 0202, Houston, Texas, United States
Local Institution - 0046, Lubbock, Texas, United States
Local Institution - 0172, Salt Lake City, Utah, United States
Local Institution - 0037, Caba, Buenos Aires, Argentina
Local Institution - 0194, Pilar Provincia De Buenos Aires, Buenos Aires, Argentina
Local Institution - 0282, Rosario, Santa Fe, Argentina
Local Institution - 0136, Buenos Aires, , Argentina
Local Institution - 0058, Tucuman, , Argentina
Local Institution - 0003, Kogarah, New South Wales, Australia
Local Institution - 0038, Liverpool, New South Wales, Australia
Local Institution - 0002, Westmead, New South Wales, Australia
Local Institution - 0004, Birtinya, Queensland, Australia
Local Institution - 0013, Herston, Queensland, Australia
Local Institution - 0009, Adelaide, South Australia, Australia
Local Institution - 0019, Clayton, Victoria, Australia
Local Institution - 0026, Fitzroy, Victoria, Australia
Local Institution - 0001, Melbourne, Victoria, Australia
Local Institution - 0020, St Albans, Victoria, Australia
Local Institution - 0114, St. Polten, Niederosterreich, Austria
Local Institution - 0057, Wiener Neustadt, Niederosterreich, Austria
Local Institution - 0188, Graz, , Austria
Local Institution - 0065, Klagenfurt, , Austria
Local Institution - 0186, Viena, , Austria
Local Institution - 0034, Brussels, , Belgium
Local Institution - 0008, Federal District, , Belgium
Local Institution - 0124, Gent, , Belgium
Local Institution - 0298, Gent, , Belgium
Local Institution - 0099, Haine-Saint-Paul, , Belgium
Local Institution - 0064, Leuven, , Belgium
Local Institution - 0104, Liege, , Belgium
Local Institution, Salvador, Bahia, Brazil
Local Institution - 0061, Salvador, Bahia, Brazil
Local Institution - 0181, Brasilia, DF, Brazil
Local Institution - 0278, Vitoria, Espirito Santo, Brazil
Local Institution - 0279, Ijui, Rio Grande Do Sul, Brazil
Local Institution - 0060, Pelotas, RIO Grande DO SUL, Brazil
Local Institution - 0054, Jau, SAO Paulo, Brazil
Local Institution - 0280, Sao Jose do Rio Preto, Sao Paulo, Brazil
Local Institution - 0016, Parana, , Brazil
Local Institution - 0015, Rio de Janeiro, , Brazil
Local Institution - 0023, Sao Paulo, , Brazil
Local Institution - 0022, Sao Paulo, , Brazil
Local Institution - 0050, Sao Paulo, , Brazil
Local Institution - 0192, Edmonton, Alberta, Canada
Local Institution - 0296, Temuco, Araucania, Chile
Local Institution - 0094, La Serena, Coquimbo, Chile
Local Institution - 0095, Santiago de Chile, Metropolitana, Chile
Local Institution - 0024, Santiago, Metropolitana, Chile
Local Institution - 0156, Santiago, Metropolitana, Chile
Local Institution - 0283, Santiago, RM, Chile
Local Institution - 0012, Vina del Mar, Valparaiso, Chile
Local Institution - 0216, Vina del Mar, Valparaiso, Chile
Local Institution - 0120, Hefei Shi, Anhui, China
Local Institution - 0146, Hefei, Anhui, China
Local Institution - 0175, Beijing, Beijing, China
Local Institution - 0152, Beijing, Beijing, China
Local Institution - 0121, Fuzhou City, Fujian, China
Local Institution - 0151, Fuzhou, Fujian, China
Local Institution - 0125, Guangzhou, Guangdong, China
Local Institution - 0150, Guangzhou, Guangdong, China
Local Institution - 0135, Harbin, Heilongjiang, China
Local Institution - 0109, Changsha, Hunan, China
Local Institution - 0059, Changsha, Hunan, China
Local Institution - 0130, Nanjing, Jiangsu, China
Local Institution - 0145, Nanchang, Jiangxi, China
Local Institution - 0149, Nanchang, Jiangxi, China
Local Institution - 0162, Changchun, Jilin, China
Local Institution - 0166, Changchun, Jilin, China
Local Institution - 0131, Dalian, Liaoning, China
Local Institution - 0123, Shenyang, Liaoning, China
Local Institution - 0132, Shenyang, Liaoning, China
Local Institution - 0307, Xi'an, Shan3xi, China
Local Institution - 0133, Xian, Shan3xi, China
Local Institution - 0147, Xian, Shan3xi, China
Local Institution - 0153, Qingdao, Shandong, China
Local Institution - 0134, Shanghai, Shanghai, China
Local Institution - 0179, Chongqing, Sichuan, China
Local Institution - 0108, Hangzhou, Zhejiang, China
Local Institution - 0107, Hangzhou, Zhejiang, China
Local Institution - 0274, Praha, Prague, Czechia
Local Institution, Brno, , Czechia
Local Institution - 0068, Amiens, , France
Local Institution - 0116, Caen, , France
Local Institution - 0069, Clichy, , France
Local Institution - 0138, Dijon, , France
Local Institution - 0081, Grenoble Cedex 9, , France
Local Institution - 0070, Lyon, , France
Local Institution, Marseille, , France
Local Institution - 0082, Montpellier, , France
Local Institution - 0067, Nice, , France
Local Institution - 0025, Pessac, , France
Local Institution - 0137, Poitiers, , France
Local Institution - 0042, Toulouse Cedex 9, , France
Local Institution - 0071, Vandoeuvre les Nancy, , France
Local Institution - 0051, Villejuif, , France
Local Institution - 0005, Frankfurt, Hessen, Germany
Local Institution - 0231, Bonn, , Germany
Local Institution - 0052, Essen, , Germany
Local Institution - 0185, Freiburg, , Germany
Local Institution - 0006, Hamburg, , Germany
Local Institution - 0102, Hannover, , Germany
Local Institution - 0028, Koeln, , Germany
Local Institution - 0118, Leipzig, , Germany
Local Institution - 0031, Mainz, , Germany
Local Institution - 0056, Mannheim, , Germany
Local Institution, Munchen, , Germany
Local Institution - 0053, North Rhine-Westphalia, , Germany
Local Institution - 0036, Hong Kong, , Hong Kong
Local Institution - 0032, Hong Kong, , Hong Kong
Local Institution - 0110, Meldola, Forli-Cesena, Italy
Local Institution - 0101, Rozzano, Milano, Italy
Local Institution - 0084, Candiolo, , Italy
Local Institution - 0039, Milano, , Italy
Local Institution - 0100, Novara, , Italy
Local Institution - 0219, Padova, , Italy
Local Institution - 0033, Parma, , Italy
Local Institution - 0112, Roma, , Italy
Local Institution - 0079, Rome, , Italy
Local Institution - 0111, Siena, , Italy
Local Institution - 0044, Vicenza, , Italy
Local Institution - 0193, Kashiwa-shi, Chiba, Japan
Local Institution - 0203, Matsuyama, Ehime, Japan
Local Institution - 0176, Kanazawa, Ishikawa, Japan
Local Institution - 0200, Yokohama-Shi, Kanagawa, Japan
Local Institution - 0262, Yokohama-shi, Kanagawa, Japan
Local Institution - 0189, Kyoto-shi, Kyoto, Japan
Local Institution - 0261, Kashihara City, Nara, Japan
Local Institution - 0263, Abeno-ku, Osaka, Japan
Local Institution - 0127, Osakasayama, Osaka, Japan
Local Institution - 0281, Saga Shi, Saga, Japan
Local Institution - 0258, Iruma-gun, Saitama, Japan
Local Institution - 0259, Izunokuni-shi, Shizuoka, Japan
Local Institution - 0122, Minato-ku, Tokyo, Japan
Local Institution - 0128, Minato, Tokyo, Japan
Local Institution - 0201, Mitaka, Tokyo, Japan
Local Institution - 0199, Musashino-shi, Tokyo, Japan
Local Institution - 0204, Chiba, , Japan
Local Institution - 0178, Fukuoka, , Japan
Local Institution - 0177, Hiroshima, , Japan
Local Institution - 0155, Sapporo, , Japan
Local Institution - 0143, Seongnam, Gyeonggi-do, Korea, Republic of
Local Institution - 0167, Guro-gu, Seoul, Korea, Republic of
Local Institution - 0062, Jongno-gu, Seoul, Korea, Republic of
Local Institution - 0142, Busan, , Korea, Republic of
Local Institution - 0097, Gyeonggi-do, , Korea, Republic of
Local Institution - 0098, Gyeongsangnam-do, , Korea, Republic of
Local Institution - 0141, Seoul, , Korea, Republic of
Local Institution - 0140, Seoul, , Korea, Republic of
Local Institution - 0139, Seoul, , Korea, Republic of
Local Institution - 0286, Christchurch, Canterbury, New Zealand
Local Institution - 0047, Auckland, , New Zealand
Local Institution - 0148, Gdansk, , Poland
Local Institution - 0049, Otwock, , Poland
Local Institution - 0092, Warszawa, , Poland
Local Institution - 0289, Rio Piedras, , Puerto Rico
Local Institution - 0035, San Juan, , Puerto Rico
Local Institution - 0103, Craiova, Dolj, Romania
Local Institution - 0164, Bucharest, , Romania
Local Institution - 0165, Cluj Napoca, , Romania
Local Institution, Craiova, , Romania
Local Institution - 0163, Timisoara, , Romania
Local Institution - 0029, Arkhangelsk, , Russian Federation
Local Institution - 0066, Barnaul, , Russian Federation
Local Institution - 0074, Chelyabinsk, , Russian Federation
Local Institution - 0007, Moscow, , Russian Federation
Local Institution - 0072, Pyatigorsk, , Russian Federation
Local Institution - 0075, Saint-Petersburg, , Russian Federation
Local Institution - 0091, Saint-Petersburg, , Russian Federation
Local Institution - 0073, Sochi, , Russian Federation
Local Institution - 0048, Singapore, , Singapore
Local Institution - 0017, Singapore, , Singapore
Local Institution - 0174, Singapore, , Singapore
Local Institution - 0297, Barcelona, , Spain
Local Institution - 0055, Barcelona, , Spain
Local Institution - 0089, Barcelona, , Spain
Local Institution - 0090, Cordoba, , Spain
Local Institution - 0087, El Palmar, , Spain
Local Institution - 0041, Madrid, , Spain
Local Institution - 0093, Madrid, , Spain
Local Institution - 0290, Madrid, , Spain
Local Institution - 0045, Majadahonda, , Spain
Local Institution - 0085, Pamplona, , Spain
Local Institution - 0088, Santander, , Spain
Local Institution - 0040, Zaragoza, , Spain
Local Institution - 0063, Bern, , Switzerland
Local Institution - 0272, Kaohsiung, , Taiwan
Local Institution - 0096, Kaohsiung, , Taiwan
Local Institution - 0105, Taichung, , Taiwan
Local Institution - 0271, Taichung, , Taiwan
Local Institution - 0168, Tainan, , Taiwan
Local Institution - 0270, Tainan, , Taiwan
Local Institution - 0144, Taipei, , Taiwan
Local Institution - 0078, Taipei, , Taiwan
Local Institution - 0173, Taoyuan, , Taiwan
Local Institution - 0171, London, Greater London, United Kingdom
Local Institution - 0154, Guildford, Surrey, United Kingdom
Local Institution - 0160, Edinburgh, , United Kingdom
Local Institution - 0129, London, , United Kingdom
Contact Details
Name: Bristol-Myers Squibb
Affiliation: Bristol-Myers Squibb
Role: STUDY_DIRECTOR
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