Spots Global Cancer Trial Database for Assess Efficacy and Safety of Durvalumab Alone or Combined With Bevacizumab in High Risk of Recurrence HCC Patients After Curative Treatment
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Trial Identification
Brief Title: Assess Efficacy and Safety of Durvalumab Alone or Combined With Bevacizumab in High Risk of Recurrence HCC Patients After Curative Treatment
Official Title: A Phase III, Randomized, Double-Blind, Placebo-Controlled, Multi Center Study of Durvalumab Monotherapy or in Combination With Bevacizumab as Adjuvant Therapy in Patients With Hepatocellular Carcinoma Who Are at High Risk of Recurrence After Curative Hepatic Resection or Ablation
Study ID: NCT03847428
Conditions
Study Description
Brief Summary: A global study to assess the efficacy and safety of durvalumab in combination with bevacizumab or durvalumab alone in patients with hepatocellular carcinoma who are at high risk of recurrence.
Detailed Description: This is a Phase III, randomized, double-blind, placebo-controlled, multi-center, global study to assess the efficacy and safety of durvalumab in combination with bevacizumab or durvalumab monotherapy or placebo as adjuvant therapy. This study will be conducted in patients with HCC who are at high risk of recurrence after curative hepatic resection or ablation.
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Research Site, Birmingham, Alabama, United States
Research Site, Mobile, Alabama, United States
Research Site, Phoenix, Arizona, United States
Research Site, Costa Mesa, California, United States
Research Site, La Jolla, California, United States
Research Site, Long Beach, California, United States
Research Site, Orange, California, United States
Research Site, Sacramento, California, United States
Research Site, Washington, District of Columbia, United States
Research Site, Miami, Florida, United States
Research Site, Tampa, Florida, United States
Research Site, Honolulu, Hawaii, United States
Research Site, Chicago, Illinois, United States
Research Site, Westwood, Kansas, United States
Research Site, Louisville, Kentucky, United States
Research Site, Shreveport, Louisiana, United States
Research Site, Detroit, Michigan, United States
Research Site, Grand Rapids, Michigan, United States
Research Site, Rochester, Minnesota, United States
Research Site, Omaha, Nebraska, United States
Research Site, New Brunswick, New Jersey, United States
Research Site, Albuquerque, New Mexico, United States
Research Site, New York, New York, United States
Research Site, Stony Brook, New York, United States
Research Site, Durham, North Carolina, United States
Research Site, Winston-Salem, North Carolina, United States
Research Site, Cleveland, Ohio, United States
Research Site, Philadelphia, Pennsylvania, United States
Research Site, Pittsburgh, Pennsylvania, United States
Research Site, Spartanburg, South Carolina, United States
Research Site, Knoxville, Tennessee, United States
Research Site, Memphis, Tennessee, United States
Research Site, Dallas, Texas, United States
Research Site, Madison, Wisconsin, United States
Research Site, Kogarah, , Australia
Research Site, Melbourne, , Australia
Research Site, Nedlands, , Australia
Research Site, Westmead, , Australia
Research Site, Innsbruck, , Austria
Research Site, Linz, , Austria
Research Site, St. Pölten, , Austria
Research Site, Florianópolis, , Brazil
Research Site, Porto Alegre, , Brazil
Research Site, Porto Alegre, , Brazil
Research Site, Rio de Janeiro, , Brazil
Research Site, Santa Maria, , Brazil
Research Site, Santo Andre, , Brazil
Research Site, São José do Rio Preto, , Brazil
Research Site, Vitória, , Brazil
Research Site, Hamilton, Ontario, Canada
Research Site, Kingston, Ontario, Canada
Research Site, Ottawa, Ontario, Canada
Research Site, Toronto, Ontario, Canada
Research Site, Toronto, Ontario, Canada
Research Site, Quebec, , Canada
Research Site, Beijing, , China
Research Site, Beijing, , China
Research Site, Beijing, , China
Research Site, Bengbu, , China
Research Site, Changchun, , China
Research Site, Changsha, , China
Research Site, Chengdu, , China
Research Site, Fuzhou, , China
Research Site, Guangzhou, , China
Research Site, Guangzhou, , China
Research Site, Guangzhou, , China
Research Site, Hangzhou, , China
Research Site, Hangzhou, , China
Research Site, Hangzhou, , China
Research Site, Harbin, , China
Research Site, Hefei, , China
Research Site, Hohhot, , China
Research Site, Nanjing, , China
Research Site, Nanjing, , China
Research Site, Ningbo, , China
Research Site, Shanghai, , China
Research Site, Tianjin, , China
Research Site, Urumqi, , China
Research Site, Wuhan, , China
Research Site, Xi'an, , China
Research Site, Zhengzhou, , China
Research Site, Alexandria, , Egypt
Research Site, Assiut, , Egypt
Research Site, Cairo, , Egypt
Research Site, Cairo, , Egypt
Research Site, Cairo, , Egypt
Research Site, Dakahlia, , Egypt
Research Site, New Cairo, , Egypt
Research Site, Shebeen El Kom, , Egypt
Research Site, Amiens Cedex 1, , France
Research Site, ANGERS Cedex 9, , France
Research Site, Besançon, , France
Research Site, Clichy, , France
Research Site, Dijon Cedex, , France
Research Site, Nantes, , France
Research Site, Nice, , France
Research Site, PARIS Cedex 12, , France
Research Site, Pessac, , France
Research Site, Toulouse Cedex 9, , France
Research Site, TOURS Cedex 9, , France
Research Site, Berlin, , Germany
Research Site, Bonn, , Germany
Research Site, Chemnitz, , Germany
Research Site, Freiburg, , Germany
Research Site, Heidelberg, , Germany
Research Site, Köln, , Germany
Research Site, Leipzig, , Germany
Research Site, Lübeck, , Germany
Research Site, München, , Germany
Research Site, Tuebingen, , Germany
Research Site, Hong Kong, , Hong Kong
Research Site, Hong Kong, , Hong Kong
Research Site, Hong Kong, , Hong Kong
Research Site, HongKong, , Hong Kong
Research Site, Kwai Chung, , Hong Kong
Research Site, Shatin, , Hong Kong
Research Site, Bangalore, , India
Research Site, Bangalore, , India
Research Site, Hyderabad, , India
Research Site, Kolkata, , India
Research Site, Mumbai, , India
Research Site, New Delhi, , India
Research Site, New Delhi, , India
Research Site, New Delhi, , India
Research Site, Bologna, , Italy
Research Site, Milano, , Italy
Research Site, Milano, , Italy
Research Site, Napoli, , Italy
Research Site, Roma, , Italy
Research Site, Tricase, Lecce, , Italy
Research Site, Verona, , Italy
Research Site, Bunkyo-ku, , Japan
Research Site, Fukuoka-shi, , Japan
Research Site, Gifu-shi, , Japan
Research Site, Hiroshima-shi, , Japan
Research Site, Koto-ku, , Japan
Research Site, Kumamoto-shi, , Japan
Research Site, Kurume-shi, , Japan
Research Site, Kyoto-shi, , Japan
Research Site, Kyoto-shi, , Japan
Research Site, Matsuyama-shi, , Japan
Research Site, Mitaka-shi, , Japan
Research Site, Musashino-shi, , Japan
Research Site, Nagasaki-shi, , Japan
Research Site, Nagoya-shi, , Japan
Research Site, Nagoya-shi, , Japan
Research Site, Osaka-shi, , Japan
Research Site, Osaka-shi, , Japan
Research Site, Osaka-shi, , Japan
Research Site, Osakasayama-shi, , Japan
Research Site, Sapporo-shi, , Japan
Research Site, Sapporo-shi, , Japan
Research Site, Sendai-shi, , Japan
Research Site, Shinagawa-ku, , Japan
Research Site, Shinjuku-ku, , Japan
Research Site, Shinjuku-ku, , Japan
Research Site, Shiwa-gun, , Japan
Research Site, Takasaki-shi, , Japan
Research Site, Tsu-shi, , Japan
Research Site, Wakayama-shi, , Japan
Research Site, Yokohama-shi, , Japan
Research Site, Yokohama-shi, , Japan
Research Site, Busan, , Korea, Republic of
Research Site, Daegu, , Korea, Republic of
Research Site, Seoul, , Korea, Republic of
Research Site, Seoul, , Korea, Republic of
Research Site, Seoul, , Korea, Republic of
Research Site, Seoul, , Korea, Republic of
Research Site, Lima, , Peru
Research Site, Lima, , Peru
Research Site, Lima, , Peru
Research Site, San Isidro, , Peru
Research Site, Manila, , Philippines
Research Site, Muntinlupa City, , Philippines
Research Site, Pasig City, , Philippines
Research Site, Bydgoszcz, , Poland
Research Site, Gdańsk, , Poland
Research Site, Poznań, , Poland
Research Site, Warszawa, , Poland
Research Site, Ponce, , Puerto Rico
Research Site, Barnaul, , Russian Federation
Research Site, Ekaterinburg, , Russian Federation
Research Site, Moscow, , Russian Federation
Research Site, Moscow, , Russian Federation
Research Site, Obninsk, , Russian Federation
Research Site, Saint Petersburg, , Russian Federation
Research Site, Saint-Petersburg, , Russian Federation
Research Site, Saint-Petersburg, , Russian Federation
Research Site, Singapore, , Singapore
Research Site, Singapore, , Singapore
Research Site, Singapore, , Singapore
Research Site, Changhua, , Taiwan
Research Site, Tainan, , Taiwan
Research Site, Taipei, , Taiwan
Research Site, Taipei, , Taiwan
Research Site, Taoyuan City, , Taiwan
Research Site, Yunlin, , Taiwan
Research Site, Bangkok, , Thailand
Research Site, Bangkok, , Thailand
Research Site, Bangkok, , Thailand
Research Site, Bangkok, , Thailand
Research Site, Chiang Mai, , Thailand
Research Site, Hat Yai, , Thailand
Research Site, Khon Kaen, , Thailand
Research Site, Pathumthani, , Thailand
Research Site, Ankara, , Turkey
Research Site, Ankara, , Turkey
Research Site, Istanbul, , Turkey
Research Site, Izmir, , Turkey
Research Site, Malatya, , Turkey
Research Site, Hanoi, , Vietnam
Research Site, Hanoi, , Vietnam
Research Site, Ho Chi Minh city, , Vietnam
Research Site, Ho Chi Minh, , Vietnam
Research Site, Hochiminh, , Vietnam
Contact Details
Name: Jia Fan, PhD
Affiliation: Liver Cancer Institute Zhongshan Hospital, Fudan University
Role: PRINCIPAL_INVESTIGATOR
Name: Jennifer Knox, MD
Affiliation: Solid Tumor Medical Oncology Princess Margaret Cancer Centre
Role: PRINCIPAL_INVESTIGATOR
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