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Spots Global Cancer Trial Database for HCC Surveillance: Comparison of Abbreviated Non-contrast MRI and Ultrasound Surveillance in Cirrhotic Patients With Suboptimal Ultrasound Visualisation

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Trial Identification

Brief Title: HCC Surveillance: Comparison of Abbreviated Non-contrast MRI and Ultrasound Surveillance in Cirrhotic Patients With Suboptimal Ultrasound Visualisation

Official Title: HCC Surveillance: Comparison of Abbreviated Non-contrast MRI and Ultrasound Surveillance in Cirrhotic Patients With Suboptimal Ultrasound Visualisation

Study ID: NCT04455932

Study Description

Brief Summary: All international guidelines recommend 6-monthly ultrasound surveillance for patients at risk for liver cancer (hepatocellular carcinoma or HCC), such as patients with cirrhosis. The aim of surveillance is to detect HCC at an early stage when it is still potentially curable. Currently only 4 out of 10 HCCs are detected at the early stage. Ultrasound surveillance for HCC has a wide ranging sensitivity, dependent on many factors such as operator experience, patient body habitus and liver parenchymal heterogeneity due to chronic liver disease and cirrhosis. In a select group of patients, surveillance ultrasound can be suboptimal or near non-diagnostic. Currently no guideline offers an alternative surveillance tool for patients who have suboptimal surveillance ultrasounds.

Detailed Description: The investigators plan to conduct a prospective study to examine the diagnostic performance of abbreviated non-contrast MRI (aNC-MRI) versus ultrasound, in a select group of cirrhotic patients with poor ultrasound visualisation.

Eligibility

Minimum Age: 20 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia

Concord Repatriation General Hospital, Concord, New South Wales, Australia

Gosford Hospital, Gosford, New South Wales, Australia

Prince of Wales Hospital, Randwick, New South Wales, Australia

Westmead Hospital, Westmead, New South Wales, Australia

Princess Alexandra Hospital, Brisbane, Queensland, Australia

St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia

Austin Hospital, Heidelberg, Victoria, Australia

Royal Perth Hospital, Perth, Western Australia, Australia

North Shore Hospital, Takapuna, Auckland, New Zealand

Contact Details

Name: Jessica Yang, MBBS

Affiliation: Concord Repatriation General Hospital

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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