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Brief Title: HCC Surveillance: Comparison of Abbreviated Non-contrast MRI and Ultrasound Surveillance in Cirrhotic Patients With Suboptimal Ultrasound Visualisation
Official Title: HCC Surveillance: Comparison of Abbreviated Non-contrast MRI and Ultrasound Surveillance in Cirrhotic Patients With Suboptimal Ultrasound Visualisation
Study ID: NCT04455932
Brief Summary: All international guidelines recommend 6-monthly ultrasound surveillance for patients at risk for liver cancer (hepatocellular carcinoma or HCC), such as patients with cirrhosis. The aim of surveillance is to detect HCC at an early stage when it is still potentially curable. Currently only 4 out of 10 HCCs are detected at the early stage. Ultrasound surveillance for HCC has a wide ranging sensitivity, dependent on many factors such as operator experience, patient body habitus and liver parenchymal heterogeneity due to chronic liver disease and cirrhosis. In a select group of patients, surveillance ultrasound can be suboptimal or near non-diagnostic. Currently no guideline offers an alternative surveillance tool for patients who have suboptimal surveillance ultrasounds.
Detailed Description: The investigators plan to conduct a prospective study to examine the diagnostic performance of abbreviated non-contrast MRI (aNC-MRI) versus ultrasound, in a select group of cirrhotic patients with poor ultrasound visualisation.
Minimum Age: 20 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
Concord Repatriation General Hospital, Concord, New South Wales, Australia
Gosford Hospital, Gosford, New South Wales, Australia
Prince of Wales Hospital, Randwick, New South Wales, Australia
Westmead Hospital, Westmead, New South Wales, Australia
Princess Alexandra Hospital, Brisbane, Queensland, Australia
St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia
Austin Hospital, Heidelberg, Victoria, Australia
Royal Perth Hospital, Perth, Western Australia, Australia
North Shore Hospital, Takapuna, Auckland, New Zealand
Name: Jessica Yang, MBBS
Affiliation: Concord Repatriation General Hospital
Role: PRINCIPAL_INVESTIGATOR