Spots Global Cancer Trial Database for A Global Study to Evaluate Transarterial Chemoembolization (TACE) in Combination With Durvalumab and Bevacizumab Therapy in Patients With Locoregional Hepatocellular Carcinoma
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Trial Identification
Brief Title: A Global Study to Evaluate Transarterial Chemoembolization (TACE) in Combination With Durvalumab and Bevacizumab Therapy in Patients With Locoregional Hepatocellular Carcinoma
Official Title: A Phase III, Randomized, Double-blind, Placebo-controlled, Multicenter Study of Transarterial Chemoembolization (TACE) in Combination With Either Durvalumab Monotherapy or Durvalumab Plus Bevacizumab Therapy in Patients With Locoregional Hepatocellular Carcinoma (EMERALD-1)
Study ID: NCT03778957
Conditions
Study Description
Brief Summary: A global study to evaluate transarterial chemoembolization (TACE) in combination with durvalumab and bevacizumab therapy in patients with locoregional hepatocellular carcinoma
Detailed Description: This is a randomized, double-blind, placebo-controlled, multicenter, global Phase III study to determine the efficacy and safety of transarterial chemoembolization (TACE) treatment in combination with durvalumab monotherapy or TACE given with durvalumab plus bevacizumab therapy compared to TACE therapy alone in patients with locoregional hepatocellular carcinoma not amenable to curative therapy
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Research Site, Mobile, Alabama, United States
Research Site, Phoenix, Arizona, United States
Research Site, Tucson, Arizona, United States
Research Site, Costa Mesa, California, United States
Research Site, La Jolla, California, United States
Research Site, Orange, California, United States
Research Site, Aurora, Colorado, United States
Research Site, Washington, District of Columbia, United States
Research Site, Jacksonville, Florida, United States
Research Site, Miami, Florida, United States
Research Site, Miami, Florida, United States
Research Site, Honolulu, Hawaii, United States
Research Site, Chicago, Illinois, United States
Research Site, Westwood, Kansas, United States
Research Site, Shreveport, Louisiana, United States
Research Site, Boston, Massachusetts, United States
Research Site, Boston, Massachusetts, United States
Research Site, Detroit, Michigan, United States
Research Site, Rochester, Minnesota, United States
Research Site, Saint Louis, Missouri, United States
Research Site, Omaha, Nebraska, United States
Research Site, Stony Brook, New York, United States
Research Site, Charlotte, North Carolina, United States
Research Site, Durham, North Carolina, United States
Research Site, Winston-Salem, North Carolina, United States
Research Site, Cleveland, Ohio, United States
Research Site, Portland, Oregon, United States
Research Site, Philadelphia, Pennsylvania, United States
Research Site, Pittsburgh, Pennsylvania, United States
Research Site, Sioux Falls, South Dakota, United States
Research Site, Knoxville, Tennessee, United States
Research Site, Memphis, Tennessee, United States
Research Site, Dallas, Texas, United States
Research Site, Dallas, Texas, United States
Research Site, Houston, Texas, United States
Research Site, Houston, Texas, United States
Research Site, Morgantown, West Virginia, United States
Research Site, Milwaukee, Wisconsin, United States
Research Site, Benowa, , Australia
Research Site, Box Hill, , Australia
Research Site, Camperdown, , Australia
Research Site, Clayton, , Australia
Research Site, Herston, , Australia
Research Site, Liverpool, , Australia
Research Site, Melbourne, , Australia
Research Site, Barretos, , Brazil
Research Site, Florianópolis, , Brazil
Research Site, Porto Alegre, , Brazil
Research Site, Porto Alegre, , Brazil
Research Site, Porto Alegre, , Brazil
Research Site, Rio de Janeiro, , Brazil
Research Site, Santa Maria, , Brazil
Research Site, Sao Paulo, , Brazil
Research Site, São José do Rio Preto, , Brazil
Research Site, Vitória, , Brazil
Research Site, Ottawa, Ontario, Canada
Research Site, Toronto, Ontario, Canada
Research Site, Toronto, Ontario, Canada
Research Site, Montreal, Quebec, Canada
Research Site, Montreal, Quebec, Canada
Research Site, Beijing, , China
Research Site, Beijing, , China
Research Site, Beijing, , China
Research Site, Beijing, , China
Research Site, Changchun, , China
Research Site, Changsha, , China
Research Site, Chengdu, , China
Research Site, Fuzhou, , China
Research Site, Fuzhou, , China
Research Site, Guangzhou, , China
Research Site, Guangzhou, , China
Research Site, Guangzhou, , China
Research Site, Hangzhou, , China
Research Site, Harbin, , China
Research Site, Hefei, , China
Research Site, Nanchang, , China
Research Site, Nanjing, , China
Research Site, Nanjing, , China
Research Site, Nantong, , China
Research Site, Neijiang, , China
Research Site, Shanghai, , China
Research Site, Shanghai, , China
Research Site, Shenyang, , China
Research Site, Shenzhen, , China
Research Site, Tianjin, , China
Research Site, Wuhan, , China
Research Site, Wuhan, , China
Research Site, Xi'an, , China
Research Site, Zhengzhou, , China
Research Site, Zhuhai, , China
Research Site, Bobigny, , France
Research Site, Clichy, , France
Research Site, Grenoble cedex 9, , France
Research Site, Montpellier CEDEX 5, , France
Research Site, Nice Cedex 3, , France
Research Site, Paris Cedex 13, , France
Research Site, Pessac, , France
Research Site, Toulouse Cedex 9, , France
Research Site, Vandoeuvre Les Nancy, , France
Research Site, Hong Kong, , Hong Kong
Research Site, Shatin, , Hong Kong
Research Site, Bangalore, , India
Research Site, Bengaluru, , India
Research Site, Hyderabad, , India
Research Site, Kolkata, , India
Research Site, Kolkata, , India
Research Site, Madurai, , India
Research Site, Mumbai, , India
Research Site, Nashik, , India
Research Site, Pune, , India
Research Site, Surat, , India
Research Site, Vijayawada, , India
Research Site, Vishakhapatnam, , India
Research Site, Arezzo, , Italy
Research Site, Brescia, , Italy
Research Site, Milano, , Italy
Research Site, Milano, , Italy
Research Site, Pisa, , Italy
Research Site, Bunkyo-ku, , Japan
Research Site, Chiba-shi, , Japan
Research Site, Chuo-ku, , Japan
Research Site, Fukuoka-shi, , Japan
Research Site, Hiroshima-shi, , Japan
Research Site, Kurume-shi, , Japan
Research Site, Musashino-shi, , Japan
Research Site, Nagoya-shi, , Japan
Research Site, Okayama, , Japan
Research Site, Osaka-shi, , Japan
Research Site, Osaka-shi, , Japan
Research Site, Osakasayama-shi, , Japan
Research Site, Sapporo-shi, , Japan
Research Site, Shiwa-gun, , Japan
Research Site, Tsu-shi, , Japan
Research Site, Yokohama-shi, , Japan
Research Site, Busan, , Korea, Republic of
Research Site, Daegu, , Korea, Republic of
Research Site, Goyang-si, , Korea, Republic of
Research Site, Seoul, , Korea, Republic of
Research Site, Seoul, , Korea, Republic of
Research Site, Seoul, , Korea, Republic of
Research Site, Seoul, , Korea, Republic of
Research Site, Alc. Cuauhtémoc, , Mexico
Research Site, Culiacan, , Mexico
Research Site, Guadalajara, , Mexico
Research Site, Mexico, , Mexico
Research Site, Monterrey, , Mexico
Research Site, Monterrey, , Mexico
Research Site, Mérida, , Mexico
Research Site, Tuxtla Gutierrez, , Mexico
Research Site, Barnaul, , Russian Federation
Research Site, Ekaterinburg, , Russian Federation
Research Site, Kazan, , Russian Federation
Research Site, Moscow, , Russian Federation
Research Site, Novosibirsk, , Russian Federation
Research Site, Obninsk, , Russian Federation
Research Site, Sankt-Peterburg, , Russian Federation
Research Site, St. Petersburg, , Russian Federation
Research Site, Bukit Merah, , Singapore
Research Site, Córdoba, , Spain
Research Site, Madrid, , Spain
Research Site, Pamplona, , Spain
Research Site, San Sebastián(Guipuzcoa), , Spain
Research Site, Kaohsiung, , Taiwan
Research Site, Liou Ying Township, , Taiwan
Research Site, Taichung, , Taiwan
Research Site, Taichung, , Taiwan
Research Site, Tainan City, , Taiwan
Research Site, Taipei, , Taiwan
Research Site, Taipei, , Taiwan
Research Site, Taoyuan City, , Taiwan
Research Site, Bangkok, , Thailand
Research Site, Bangkok, , Thailand
Research Site, Bangkok, , Thailand
Research Site, Chiang Mai, , Thailand
Research Site, Hat Yai, , Thailand
Research Site, Khon Kaen, , Thailand
Research Site, Phisanulok, , Thailand
Research Site, Hanoi, , Vietnam
Research Site, Hanoi, , Vietnam
Research Site, Ho Chi Minh City, , Vietnam
Research Site, Ho Chi Minh, , Vietnam
Contact Details
Name: Bruno Sangro, MD
Affiliation: Clinica Universidad de Navarra
Role: PRINCIPAL_INVESTIGATOR
Name: Riccardo Lencioni, MD FSIR EBIR
Affiliation: University of Pisa / Miami Cancer Institute
Role: PRINCIPAL_INVESTIGATOR
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