Spots Global Cancer Trial Database for Immunological Response After Ablative Therapy in the Liver
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Trial Identification
Brief Title: Immunological Response After Ablative Therapy in the Liver
Official Title: Comparison of Immunological Response After Microwave Ablation and Irreversible Electroporation of Hepatocellular Carcinoma
Study ID: NCT03040453
Study Description
Brief Summary: Local ablative treatment of Hepatocellular Carcinoma is performed primary on patients not eligible for liver transplant or liver resection. At our Hospital two different methods are used: Microwave ablation, where the tumor cells are heated up and killed, and Irreversible electroporation, where the tumor cells are exposed to an electrical field and nano-pores are formed in the cell membranes and the cells go into apoptosis (programed cell death). Previous studies have shown effects on the immune system after ablative therapies. The purpose of this study is to compare the immunological response after the wo different methods of killing the tumor cells.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Department of Surgery and Urology, Danderyd Hospital, Stockholm, , Sweden
Contact Details
Name: Jacob Freedman, MD, PhD
Affiliation: Karolinska Instituet
Role: PRINCIPAL_INVESTIGATOR
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