Spots Global Cancer Trial Database for HAIC Plus Sorafenib Versus TACE Plus Sorafenibfor Advanced HCC
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Trial Identification
Brief Title: HAIC Plus Sorafenib Versus TACE Plus Sorafenibfor Advanced HCC
Official Title: The Efficacy and Safety of Hepatic Arterial Infusion Chemotherapy Plus Sorafenib Compared With Transarterial Chemoembolization Plus Sorafenib in Patients With BCLC C Stage Hepatocellular Carcinoma
Study ID: NCT02856126
Conditions
Study Description
Brief Summary: The purpose of this study is to evaluate the efficacy and safety of hepatic arterial infusion chemotherapy (HAIC) compared with transarterial chemoembolization (TACE) in patients with BCLC stage hepatocellular carcinoma (HCC).
Detailed Description: Transarterial chemoembolization (TACE) is the most widely used palliative treatment for hepatocellular carcinoma (HCC) patients. Our previous prospective study also revealed that TACE confers a survival benefit to patients with HCC and portal venous tumor thrombus (PVTT). Recently, the results of our preliminary pilot study suggested that, compared with TACE, hepatic arterial infusion chemotherapy (HAIC) may improve the survivals for patitens with BCLC stage C HCC. Thus, the investigators carried out this prospective randomized control study to find out it.
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Dongguan People's Hospital, Dongguan, Guangdong, China
Cancer Center Sun Yat-sen University, Guangzhou, Guangdong, China
The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China
Guangzhou Twelfth People 's Hospital, Guangzhou, Guangdong, China
Kaiping Central Hospital, Kaiping, Guangdong, China
The First Affiliated Hospital of University Of South China, Hengyang, Hunan, China
The First Affiliated Hospital Of Xi'an Jiaotong University, Xi'an, Shanxi, China
Contact Details
Name: Ming Shi, MD
Affiliation: The Department of Hepatobiliary Oncology of Sun Yat-sen University Cancer Center
Role: PRINCIPAL_INVESTIGATOR
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