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Brief Title: A Study of TACE Combined With Atezolizumab Plus Bevacizumab or TACE Alone in Patients With Untreated Heaptocellular Carcionma
Official Title: A Phase III, Open-Label, Randomized Study of On-Demand TACE Combined With Atezolizumab Plus Bevacizumab (Atezo/Bev) or On-Demand TACE Alone in Patients With Untreated Heaptocellular Carcionma
Study ID: NCT04712643
Brief Summary: This study will evaluate the efficacy and safety of atezolizumab plus bevacizumab combined with on-demand TACE compared to on-demand TACE alone in participants with hepatocellular carcinoma who are at high risk of poorer outcome following TACE treatment.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Peking University First Hospital, Beijing City, , China
Beijing You An Hospital; Digestive Dept, Beijing City, , China
Beijing Tsinghua Changgung Hospital, Beijing City, , China
Peking University People's Hospital, Beijing, , China
Hunan Cancer Hospital, Changsha CITY, , China
Sichuan Cancer Hospital, Chengdu City, , China
West China Hospital, Sichuan University; Surgical Oncology, Chengdu City, , China
The First Affiliated Hospital, Chongqing Medical University, Chongqing, , China
Southwest Hospital , Third Military Medical University, Chongqing, , China
The First Affiliated Hospital Of Fujian Medical University, Fuzhou City, , China
Mengchao Hepatobiliary Hospital Of Fujian Medical University, Fuzhou City, , China
The 900th Hospital of PLA joint service support force, Fuzhou, , China
Fujian Cancer Hospital, Fuzhou, , China
The First Affiliated Hospital of Sun Yat-sen University, Guangzhou City, , China
Sun Yet-sen University Cancer Center, Guangzhou City, , China
Nanfang Hospital, Southern Medical University, Guangzhou, , China
Harbin Medical University Cancer Hospital; internal medicine, Harbin City, , China
Anhui Provincial Hospital, Hefei, , China
Jiangsu Province Hospital (the First Affiliated Hospital With Nanjing Medical University), Nanjing City, , China
Jiangsu Cancer Hospital, Nanjing City, , China
Guangxi Cancer Hospital of Guangxi Medical University, Nanning City, , China
The First Affiliate Hospital of Guangxi Medical University, Nanning, , China
Zhongshan Hospital Fudan Unvierstiy, Shanghai City, , China
Fudan University Shanghai Cancer Center, Shanghai City, , China
Renji Hospital Shanghai Jiaotong University School of Medicine, Shanghai City, , China
Shengjing Hospital of China Medical University, ShenYang, , China
Tianjin Cancer Hospital; Surgical Department, Tianjin City, , China
The First Affiliated Hospital of Xi'an Jiaotong University; Hepatobiliary surgery Department, Xi'an, , China
Xi'an Inernational Medical Center Hospital, Xi'an, , China
Zhejiang Cancer Hospital, Zhejiang, , China
Henan Cancer Hospital, Zhengzhou, , China
Zhuhai People's Hospital, Zhuhai, , China
Aichi Cancer Center, Aichi, , Japan
Chiba University Hospital, Chiba, , Japan
Kurume University Hospital, Fukuoka, , Japan
Hiroshima University Hospital, Hiroshima, , Japan
Yokohama City University Medical Center, Kanagawa, , Japan
Kanagawa Cancer Center, Kanagawa, , Japan
Kitasato University Hospital, Kanagawa, , Japan
Osaka University Hospital, Osaka, , Japan
Kindai University Hospital, Osaka, , Japan
Toranomon Hospital, Tokyo, , Japan
Name: Clinical Trials
Affiliation: Hoffmann-La Roche
Role: STUDY_DIRECTOR