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Spots Global Cancer Trial Database for Trial of S-1 in Combination With Sorafenib for Patients With Advanced Hepatocellular Carcinoma

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Trial Identification

Brief Title: Trial of S-1 in Combination With Sorafenib for Patients With Advanced Hepatocellular Carcinoma

Official Title: Phase 1 Trial of S-1 in Combination With Sorafenib for Patients With Advanced Hepatocellular Carcinoma

Study ID: NCT01131689

Interventions

sorafenib, TS-1

Study Description

Brief Summary: In preclinical studies, 5-fluorouracil, one of the active metabolites of S-1, showed synergistic effect to sorafenib in human colon carcinoma cell lines. Therefore, sorafenib combined with S-1 might be more effective treatment for patients with advanced HCC than sorafenib monotherapy. The investigators propose to conduct a phase I study to determine maximal tolerated dose (MTD) of S-1 in combination with fixed dose of sorafenib in patients with advanced HCC

Detailed Description:

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Samsung Medical Center, Seoul, , Korea, Republic of

Contact Details

Useful links and downloads for this trial

Clinicaltrials.gov

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