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Brief Title: Patients With Brain Metastases From HER2-positive Breast Cancer
Official Title: A Phase I Study to Evaluate the Feasibility of Different Sequences of Combined Trastuzumab Emtansine (T-DM1) and Whole-brain Radiotherapy in Patients With Brain Metastases From HER2-positive Breast Cancer
Study ID: NCT02135159
Brief Summary: The purpose of this study is to determine the optimal sequences of combined trastuzumab emtansine (T-DM1) and whole-brain radiotherapy in patients presenting brain metastases from HER2-positive breast cancer in terms of acute toxicities and blood/cerebrospinal fluid T-DM1 pharmacokinetics.
Detailed Description: Determine the best sequences.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Institut regional du Cancer - Val d Aurelle, Montpellier, , France
Name: David AZRIA
Affiliation: ICM Co. Ltd.
Role: PRINCIPAL_INVESTIGATOR