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Brief Title: Study of ORM-5029 in Subjects With HER2-Expressing Advanced Solid Tumors
Official Title: Phase I Multicenter, Open-Label, First-in-Human Study of ORM-5029 in Subjects With HER2-Expressing Advanced Solid Tumors
Study ID: NCT05511844
Brief Summary: This is a Phase 1 first-in-human study of ORM-5029 in participants with HER2-expressing advanced solid tumors. The study consists of two parts: a Part 1 Dose Escalation and Part 2 Dose Expansion.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
University of Alabama Birmingham, Birmingham, Alabama, United States
University of California - Los Angeles, Los Angeles, California, United States
Dana Farber Cancer Institute, Boston, Massachusetts, United States
Washington University, Saint Louis, Missouri, United States
Weill Cornell Medicine-New York, New York, New York, United States
Sarah Cannon Research Institute at Tennessee Oncology, Nashville, Tennessee, United States
MD Anderson Cancer Center, Houston, Texas, United States
NEXT Oncology, San Antonio, Texas, United States
NEXT Oncology - Virginia Cancer Specialists, Fairfax, Virginia, United States