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Spots Global Cancer Trial Database for Capecitabine and Lapatinib Ditosylate With or Without Cixutumumab in Treating Patients With Previously Treated HER2-Positive Stage IIIB-IV Breast Cancer

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We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Capecitabine and Lapatinib Ditosylate With or Without Cixutumumab in Treating Patients With Previously Treated HER2-Positive Stage IIIB-IV Breast Cancer

Official Title: Randomized Phase II Trial of Capecitabine and Lapatinib With or Without IMC-A12 in Patients With HER2 Positive Breast Cancer Previously Treated With Trastuzumab and an Anthracycline and/or a Taxane

Study ID: NCT00684983

Study Description

Brief Summary: This phase II trial studies capecitabine and lapatinib ditosylate to see how well they work compared with capecitabine, lapatinib ditosylate, and cixutumumab in treating patients with previously treated HER2-positive stage IIIB-IV breast cancer. Drugs used in chemotherapy, such as capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Lapatinib ditosylate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Immunotherapy with cixutumumab, may induce changes in body's immune system and may interfere with the ability of tumor cells to grow and spread. It is not yet known whether capecitabine and lapatinib ditosylate are more effective when given with or without cixutumumab in treating breast cancer that has spread nearby or to other areas of the body.

Detailed Description: PRIMARY OBJECTIVE: I. To compare progression-free survival of HER2+ breast cancer patients randomized to receive lapatinib ditosylate (lapatinib) and capecitabine +/- cixutumumab (IMC-A12). SECONDARY OBJECTIVES: I. To assess the safety and tolerability of lapatinib and capecitabine +/- IMC-A12 in HER2+ breast cancer patients. II. To compare the overall survival time, time to treatment failure, confirmed tumor response rate, and duration of response of lapatinib and capecitabine +/- IMC-A12 in HER2+ breast cancer patients. III. To assess patient compliance per treatment arm and to compare overall quality of life and treatment side effects via patient-reported outcomes between treatment arms. TRANSLATIONAL RESEARCH OBJECTIVES: I. To determine the role of the following in predicting response to lapatinib and capecitabine +/- IMC-A12: Ia. Expression patterns and/or activation IGF- and ErbB family of receptors and signaling molecules in formalin-fixed, paraffin-embedded breast tumor tissue. Ib. Expression patterns and/or activation IGF- and ErbB receptors and signaling molecules in circulating tumor cells from breast cancer patients. Ic. Changes in expression patterns and/or activation IGF- and ErbB receptors and signaling molecules following treatment with lapatinib and capecitabine +/- IMC-A12 in circulating tumor cells from breast cancer patients. Id. Expression patterns of IGF-1, IGF-II, insulin, growth hormone, and the IGF binding proteins in the serum of breast cancer patients. Ie. Changes in expression patterns of IGF-1, IGF-II, insulin, growth hormone, and the IGF binding proteins in the serum of breast cancer patients. II. Banking of paraffin-embedded tissue blocks/slides and blood products (i.e., serum, plasma, and buffy coat) for future studies. III. To assess the proportion of patients whose pathologic specimens were correctly diagnosed as HER2 positive (according to 2007 American Society of Clinical Oncology \[ASCO\] College of American Pathologist \[CAP\] guidelines) metastatic breast cancer. OUTLINE: The first 10 patients enrolled on this study are assigned to cohort I (safety analysis). All other patients are assigned to cohort II (randomized treatment). COHORT I (SAFETY ANALYSIS, closed to accrual): Patients receive cixutumumab intravenously (IV) over 1 hour on days 1, 8, and 15. Patients also receive capecitabine orally (PO) twice daily (BID) on days 1-14 and lapatinib ditosylate PO once daily (QD) on days 1-21. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity. COHORT II (RANDOMIZED TREATMENT): Patients are randomized to 1 of 2 treatment arms. ARM A: Patients receive capecitabine PO BID on days 1-14 and lapatinib ditosylate PO QD on days 1-21. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity. ARM B: Patients receive capecitabine and lapatinib ditosylate as in Arm A. Patients also receive cixutumumab IV over 1 hour on days 1, 8, and 15. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity. After completion of study treatment, patients are followed up every 3 months until disease progression and then every 6 months for up to 5 years.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Providence Hospital, Mobile, Alabama, United States

Mayo Clinic in Arizona, Scottsdale, Arizona, United States

Alta Bates Summit Medical Center-Herrick Campus, Berkeley, California, United States

Mills-Peninsula Medical Center, Burlingame, California, United States

East Bay Radiation Oncology Center, Castro Valley, California, United States

Eden Hospital Medical Center, Castro Valley, California, United States

Valley Medical Oncology Consultants-Castro Valley, Castro Valley, California, United States

Bay Area Breast Surgeons Inc, Emeryville, California, United States

Valley Medical Oncology Consultants-Fremont, Fremont, California, United States

Glendale Memorial Hospital and Health Center, Glendale, California, United States

Contra Costa Regional Medical Center, Martinez, California, United States

El Camino Hospital, Mountain View, California, United States

Palo Alto Medical Foundation-Camino Division, Mountain View, California, United States

Sutter Cancer Research Consortium, Novato, California, United States

Highland General Hospital, Oakland, California, United States

Alta Bates Summit Medical Center - Summit Campus, Oakland, California, United States

Bay Area Tumor Institute, Oakland, California, United States

Hematology and Oncology Associates-Oakland, Oakland, California, United States

Tom K Lee Inc, Oakland, California, United States

Desert Regional Medical Center, Palm Springs, California, United States

Palo Alto Medical Foundation Health Care, Palo Alto, California, United States

Valley Care Health System - Pleasanton, Pleasanton, California, United States

Valley Medical Oncology Consultants, Pleasanton, California, United States

Salinas Valley Memorial, Salinas, California, United States

California Pacific Medical Center-Pacific Campus, San Francisco, California, United States

Doctors Medical Center- JC Robinson Regional Cancer Center, San Pablo, California, United States

Sutter Solano Medical Center/Cancer Center, Vallejo, California, United States

The Medical Center of Aurora, Aurora, Colorado, United States

Boulder Community Hospital, Boulder, Colorado, United States

Penrose-Saint Francis Healthcare, Colorado Springs, Colorado, United States

Kaiser Permanente-Franklin, Denver, Colorado, United States

Porter Adventist Hospital, Denver, Colorado, United States

Presbyterian - Saint Lukes Medical Center - Health One, Denver, Colorado, United States

SCL Health Saint Joseph Hospital, Denver, Colorado, United States

Rose Medical Center, Denver, Colorado, United States

Western States Cancer Research NCORP, Denver, Colorado, United States

Swedish Medical Center, Englewood, Colorado, United States

Poudre Valley Hospital, Fort Collins, Colorado, United States

Saint Mary's Hospital and Regional Medical Center, Grand Junction, Colorado, United States

North Colorado Medical Center, Greeley, Colorado, United States

Kaiser Permanente-Rock Creek, Lafayette, Colorado, United States

Saint Anthony Hospital, Lakewood, Colorado, United States

Sky Ridge Medical Center, Lone Tree, Colorado, United States

Longmont United Hospital, Longmont, Colorado, United States

McKee Medical Center, Loveland, Colorado, United States

Saint Mary Corwin Medical Center, Pueblo, Colorado, United States

North Suburban Medical Center, Thornton, Colorado, United States

SCL Health Lutheran Medical Center, Wheat Ridge, Colorado, United States

Smilow Cancer Hospital Care Center at Saint Francis, Hartford, Connecticut, United States

Middlesex Hospital, Middletown, Connecticut, United States

The Hospital of Central Connecticut, New Britain, Connecticut, United States

Lynn Regional Cancer Center - West, Boca Raton, Florida, United States

Holy Cross Hospital, Fort Lauderdale, Florida, United States

Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood, Florida, United States

Mayo Clinic in Florida, Jacksonville, Florida, United States

Jupiter Medical Center, Jupiter, Florida, United States

Mount Sinai Medical Center, Miami Beach, Florida, United States

AdventHealth Orlando, Orlando, Florida, United States

Sacred Heart Hospital, Pensacola, Florida, United States

John B Amos Cancer Center, Columbus, Georgia, United States

Memorial Health University Medical Center, Savannah, Georgia, United States

South Georgia Medical Center/Pearlman Cancer Center, Valdosta, Georgia, United States

Saint Alphonsus Cancer Care Center-Boise, Boise, Idaho, United States

Saint Joseph Regional Medical Center, Lewiston, Idaho, United States

Saint Anthony's Health, Alton, Illinois, United States

Rush - Copley Medical Center, Aurora, Illinois, United States

Advocate Illinois Masonic Medical Center, Chicago, Illinois, United States

Decatur Memorial Hospital, Decatur, Illinois, United States

Joliet Oncology-Hematology Associates Limited, Joliet, Illinois, United States

Good Samaritan Regional Health Center, Mount Vernon, Illinois, United States

Memorial Medical Center, Springfield, Illinois, United States

Carle Cancer Center, Urbana, Illinois, United States

Franciscan Saint Francis Health-Beech Grove, Beech Grove, Indiana, United States

Elkhart Clinic, Elkhart, Indiana, United States

Michiana Hematology Oncology PC-Elkhart, Elkhart, Indiana, United States

Elkhart General Hospital, Elkhart, Indiana, United States

Fort Wayne Medical Oncology and Hematology Inc-Parkview, Fort Wayne, Indiana, United States

Community Howard Regional Health, Kokomo, Indiana, United States

IU Health La Porte Hospital, La Porte, Indiana, United States

Franciscan Saint Anthony Health-Michigan City, Michigan City, Indiana, United States

Michiana Hematology Oncology PC-Mishawaka, Mishawaka, Indiana, United States

Saint Joseph Regional Medical Center-Mishawaka, Mishawaka, Indiana, United States

Michiana Hematology Oncology PC-Plymouth, Plymouth, Indiana, United States

Reid Health, Richmond, Indiana, United States

Memorial Hospital of South Bend, South Bend, Indiana, United States

Michiana Hematology Oncology PC-South Bend, South Bend, Indiana, United States

South Bend Clinic, South Bend, Indiana, United States

Northern Indiana Cancer Research Consortium, South Bend, Indiana, United States

Michiana Hematology Oncology PC-Westville, Westville, Indiana, United States

McFarland Clinic PC - Ames, Ames, Iowa, United States

University of Iowa Healthcare Cancer Services Quad Cities, Bettendorf, Iowa, United States

Mercy Hospital, Cedar Rapids, Iowa, United States

Oncology Associates at Mercy Medical Center, Cedar Rapids, Iowa, United States

Medical Oncology and Hematology Associates-West Des Moines, Clive, Iowa, United States

Genesis Medical Center - East Campus, Davenport, Iowa, United States

Genesis Cancer Care Institute, Davenport, Iowa, United States

Mercy Capitol, Des Moines, Iowa, United States

Iowa Methodist Medical Center, Des Moines, Iowa, United States

Iowa-Wide Oncology Research Coalition NCORP, Des Moines, Iowa, United States

Medical Oncology and Hematology Associates-Des Moines, Des Moines, Iowa, United States

Medical Oncology and Hematology Associates-Laurel, Des Moines, Iowa, United States

Mercy Medical Center - Des Moines, Des Moines, Iowa, United States

Iowa Lutheran Hospital, Des Moines, Iowa, United States

Finley Hospital, Dubuque, Iowa, United States

Mercy Medical Center - North Iowa, Mason City, Iowa, United States

Ottumwa Regional Health Center, Ottumwa, Iowa, United States

Siouxland Regional Cancer Center, Sioux City, Iowa, United States

Mercy Medical Center-Sioux City, Sioux City, Iowa, United States

Saint Luke's Regional Medical Center, Sioux City, Iowa, United States

Cancer Center of Kansas - Chanute, Chanute, Kansas, United States

Cancer Center of Kansas - Dodge City, Dodge City, Kansas, United States

Cancer Center of Kansas - El Dorado, El Dorado, Kansas, United States

Cancer Center of Kansas - Fort Scott, Fort Scott, Kansas, United States

Cancer Center of Kansas-Independence, Independence, Kansas, United States

Cancer Center of Kansas-Kingman, Kingman, Kansas, United States

Lawrence Memorial Hospital, Lawrence, Kansas, United States

Cancer Center of Kansas-Liberal, Liberal, Kansas, United States

Cancer Center of Kansas - McPherson, McPherson, Kansas, United States

Cancer Center of Kansas - Newton, Newton, Kansas, United States

Cancer Center of Kansas - Parsons, Parsons, Kansas, United States

Cancer Center of Kansas - Pratt, Pratt, Kansas, United States

Cancer Center of Kansas - Salina, Salina, Kansas, United States

Cotton O'Neil Cancer Center / Stormont Vail Health, Topeka, Kansas, United States

Cancer Center of Kansas - Wellington, Wellington, Kansas, United States

Associates In Womens Health, Wichita, Kansas, United States

Cancer Center of Kansas-Wichita Medical Arts Tower, Wichita, Kansas, United States

Ascension Via Christi Hospitals Wichita, Wichita, Kansas, United States

Cancer Center of Kansas - Wichita, Wichita, Kansas, United States

Wichita NCI Community Oncology Research Program, Wichita, Kansas, United States

Cancer Center of Kansas - Winfield, Winfield, Kansas, United States

Tulane University Health Sciences Center, New Orleans, Louisiana, United States

University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland, United States

Suburban Hospital, Bethesda, Maryland, United States

Cancer Trials Support Unit, Rockville, Maryland, United States

Holy Cross Hospital, Silver Spring, Maryland, United States

Bixby Medical Center, Adrian, Michigan, United States

Hickman Cancer Center, Adrian, Michigan, United States

Michigan Cancer Research Consortium NCORP, Ann Arbor, Michigan, United States

Saint Joseph Mercy Hospital, Ann Arbor, Michigan, United States

Bronson Battle Creek, Battle Creek, Michigan, United States

Spectrum Health Big Rapids Hospital, Big Rapids, Michigan, United States

Beaumont Hospital - Dearborn, Dearborn, Michigan, United States

Ascension Saint John Hospital, Detroit, Michigan, United States

Green Bay Oncology - Escanaba, Escanaba, Michigan, United States

Genesys Hurley Cancer Institute, Flint, Michigan, United States

Hurley Medical Center, Flint, Michigan, United States

Genesys Regional Medical Center-West Flint Campus, Flint, Michigan, United States

Cancer Research Consortium of West Michigan NCORP, Grand Rapids, Michigan, United States

Mercy Health Saint Mary's, Grand Rapids, Michigan, United States

Spectrum Health at Butterworth Campus, Grand Rapids, Michigan, United States

Green Bay Oncology - Iron Mountain, Iron Mountain, Michigan, United States

Allegiance Health, Jackson, Michigan, United States

Bronson Methodist Hospital, Kalamazoo, Michigan, United States

West Michigan Cancer Center, Kalamazoo, Michigan, United States

Borgess Medical Center, Kalamazoo, Michigan, United States

Sparrow Hospital, Lansing, Michigan, United States

Saint Mary Mercy Hospital, Livonia, Michigan, United States

UP Health System Marquette, Marquette, Michigan, United States

Mercy Memorial Hospital, Monroe, Michigan, United States

Toledo Clinic Cancer Centers-Monroe, Monroe, Michigan, United States

McLaren Cancer Institute-Macomb, Mount Clemens, Michigan, United States

Mercy Health Partners-Hackley Campus, Muskegon, Michigan, United States

Mercy Health Mercy Campus, Muskegon, Michigan, United States

Lakeland Hospital Niles, Niles, Michigan, United States

Saint Joseph Mercy Oakland, Pontiac, Michigan, United States

Lake Huron Medical Center, Port Huron, Michigan, United States

Ascension Saint Mary's Hospital, Saginaw, Michigan, United States

Lakeland Medical Center Saint Joseph, Saint Joseph, Michigan, United States

Marie Yeager Cancer Center, Saint Joseph, Michigan, United States

Munson Medical Center, Traverse City, Michigan, United States

Saint John Macomb-Oakland Hospital, Warren, Michigan, United States

Metro Health Hospital, Wyoming, Michigan, United States

Medini, Eitan MD (UIA Investigator), Alexandria, Minnesota, United States

Sanford Joe Lueken Cancer Center, Bemidji, Minnesota, United States

Fairview Ridges Hospital, Burnsville, Minnesota, United States

Mercy Hospital, Coon Rapids, Minnesota, United States

Fairview-Southdale Hospital, Edina, Minnesota, United States

Etzell, Paul S MD (UIA Investigator), Fergus Falls, Minnesota, United States

Lake Region Healthcare Corporation-Cancer Care, Fergus Falls, Minnesota, United States

Swenson, Wade II, MD (UIA Investigator), Fergus Falls, Minnesota, United States

Unity Hospital, Fridley, Minnesota, United States

Hutchinson Area Health Care, Hutchinson, Minnesota, United States

Meeker County Memorial Hospital, Litchfield, Minnesota, United States

Minnesota Oncology Hematology PA-Maplewood, Maplewood, Minnesota, United States

Saint John's Hospital - Healtheast, Maplewood, Minnesota, United States

Abbott-Northwestern Hospital, Minneapolis, Minnesota, United States

Virginia Piper Cancer Institute, Minneapolis, Minnesota, United States

Hennepin County Medical Center, Minneapolis, Minnesota, United States

North Memorial Medical Health Center, Robbinsdale, Minnesota, United States

Mayo Clinic, Rochester, Minnesota, United States

Coborn Cancer Center at Saint Cloud Hospital, Saint Cloud, Minnesota, United States

Saint Cloud Hospital, Saint Cloud, Minnesota, United States

Metro Minnesota Community Oncology Research Consortium, Saint Louis Park, Minnesota, United States

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park, Minnesota, United States

Regions Hospital, Saint Paul, Minnesota, United States

United Hospital, Saint Paul, Minnesota, United States

Saint Francis Regional Medical Center, Shakopee, Minnesota, United States

Lakeview Hospital, Stillwater, Minnesota, United States

Ridgeview Medical Center, Waconia, Minnesota, United States

Rice Memorial Hospital, Willmar, Minnesota, United States

Minnesota Oncology Hematology PA-Woodbury, Woodbury, Minnesota, United States

Singing River Hospital, Pascagoula, Mississippi, United States

Central Care Cancer Center - Bolivar, Bolivar, Missouri, United States

Cox Cancer Center Branson, Branson, Missouri, United States

Southeast Missouri Hospital, Cape Girardeau, Missouri, United States

Saint Francis Medical Center, Cape Girardeau, Missouri, United States

Delbert Day Cancer Institute at PCRMC, Rolla, Missouri, United States

Saint Louis Cancer and Breast Institute-South City, Saint Louis, Missouri, United States

Mercy Hospital Saint Louis, Saint Louis, Missouri, United States

Saint Louis-Cape Girardeau CCOP, Saint Louis, Missouri, United States

Cancer Research for the Ozarks NCORP, Springfield, Missouri, United States

Mercy Hospital Springfield, Springfield, Missouri, United States

CoxHealth South Hospital, Springfield, Missouri, United States

Billings Clinic Cancer Center, Billings, Montana, United States

Northern Rockies Radiation Oncology Center, Billings, Montana, United States

Saint Vincent Healthcare, Billings, Montana, United States

Montana Cancer Consortium NCORP, Billings, Montana, United States

Saint Vincent Frontier Cancer Center, Billings, Montana, United States

Bozeman Deaconess Hospital, Bozeman, Montana, United States

Saint James Community Hospital and Cancer Treatment Center, Butte, Montana, United States

Benefis Healthcare- Sletten Cancer Institute, Great Falls, Montana, United States

Berdeaux, Donald MD (UIA Investigator), Great Falls, Montana, United States

Great Falls Clinic, Great Falls, Montana, United States

Northern Montana Hospital, Havre, Montana, United States

Saint Peter's Community Hospital, Helena, Montana, United States

Glacier Oncology PLLC, Kalispell, Montana, United States

Kalispell Medical Oncology, Kalispell, Montana, United States

Kalispell Regional Medical Center, Kalispell, Montana, United States

Montana Cancer Specialists, Missoula, Montana, United States

Saint Patrick Hospital - Community Hospital, Missoula, Montana, United States

Community Medical Hospital, Missoula, Montana, United States

Guardian Oncology and Center for Wellness, Missoula, Montana, United States

University Medical Center of Southern Nevada, Las Vegas, Nevada, United States

Nevada Cancer Research Foundation CCOP, Las Vegas, Nevada, United States

Virtua Memorial, Mount Holly, New Jersey, United States

Virtua Voorhees, Voorhees, New Jersey, United States

University of New Mexico Cancer Center, Albuquerque, New Mexico, United States

Montefiore Medical Center-Weiler Hospital, Bronx, New York, United States

Montefiore Medical Center-Wakefield Campus, Bronx, New York, United States

Montefiore Medical Center - Moses Campus, Bronx, New York, United States

Hematology Oncology Associates of Central New York-East Syracuse, East Syracuse, New York, United States

Glens Falls Hospital, Glens Falls, New York, United States

Orange Regional Medical Center, Middletown, New York, United States

Staten Island University Hospital, Staten Island, New York, United States

Novant Health Presbyterian Medical Center, Charlotte, North Carolina, United States

Wayne Memorial Hospital, Goldsboro, North Carolina, United States

Margaret R Pardee Memorial Hospital, Hendersonville, North Carolina, United States

Vidant Oncology-Kinston, Kinston, North Carolina, United States

Iredell Memorial Hospital, Statesville, North Carolina, United States

Mid Dakota Clinic, Bismarck, North Dakota, United States

Saint Alexius Medical Center, Bismarck, North Dakota, United States

Sanford Bismarck Medical Center, Bismarck, North Dakota, United States

Sanford Broadway Medical Center, Fargo, North Dakota, United States

Altru Cancer Center, Grand Forks, North Dakota, United States

Trinity Cancer Care Center, Minot, North Dakota, United States

Cleveland Clinic Akron General, Akron, Ohio, United States

Mary Rutan Hospital, Bellefontaine, Ohio, United States

Toledo Clinic Cancer Centers-Bowling Green, Bowling Green, Ohio, United States

Adena Regional Medical Center, Chillicothe, Ohio, United States

North Coast Cancer Care-Clyde, Clyde, Ohio, United States

Riverside Methodist Hospital, Columbus, Ohio, United States

Columbus NCI Community Oncology Research Program, Columbus, Ohio, United States

Grant Medical Center, Columbus, Ohio, United States

Mount Carmel Health Center West, Columbus, Ohio, United States

Doctors Hospital, Columbus, Ohio, United States

Grandview Hospital, Dayton, Ohio, United States

Good Samaritan Hospital - Dayton, Dayton, Ohio, United States

Miami Valley Hospital, Dayton, Ohio, United States

Miami Valley Hospital North, Dayton, Ohio, United States

Dayton NCI Community Oncology Research Program, Dayton, Ohio, United States

Grady Memorial Hospital, Delaware, Ohio, United States

Hematology Oncology Center Incorporated, Elyria, Ohio, United States

Mercy Cancer Center-Elyria, Elyria, Ohio, United States

Blanchard Valley Hospital, Findlay, Ohio, United States

Atrium Medical Center-Middletown Regional Hospital, Franklin, Ohio, United States

Wayne Hospital, Greenville, Ohio, United States

Kettering Medical Center, Kettering, Ohio, United States

Fairfield Medical Center, Lancaster, Ohio, United States

Saint Rita's Medical Center, Lima, Ohio, United States

Lima Memorial Hospital, Lima, Ohio, United States

Marietta Memorial Hospital, Marietta, Ohio, United States

Saint Luke's Hospital, Maumee, Ohio, United States

Toledo Clinic Cancer Centers-Maumee, Maumee, Ohio, United States

Toledo Radiation Oncology at Northwest Ohio Onocolgy Center, Maumee, Ohio, United States

Knox Community Hospital, Mount Vernon, Ohio, United States

Licking Memorial Hospital, Newark, Ohio, United States

Fisher-Titus Medical Center, Norwalk, Ohio, United States

Saint Charles Hospital, Oregon, Ohio, United States

Toledo Clinic Cancer Centers-Oregon, Oregon, Ohio, United States

Southern Ohio Medical Center, Portsmouth, Ohio, United States

North Coast Cancer Care, Sandusky, Ohio, United States

Springfield Regional Medical Center, Springfield, Ohio, United States

ProMedica Flower Hospital, Sylvania, Ohio, United States

Mercy Hospital of Tiffin, Tiffin, Ohio, United States

The Toledo Hospital/Toledo Children's Hospital, Toledo, Ohio, United States

Saint Vincent Mercy Medical Center, Toledo, Ohio, United States

University of Toledo, Toledo, Ohio, United States

Toledo Community Hospital Oncology Program CCOP, Toledo, Ohio, United States

Mercy Saint Anne Hospital, Toledo, Ohio, United States

Toledo Clinic Cancer Centers-Toledo, Toledo, Ohio, United States

Upper Valley Medical Center, Troy, Ohio, United States

Fulton County Health Center, Wauseon, Ohio, United States

Saint Ann's Hospital, Westerville, Ohio, United States

Clinton Memorial Hospital, Wilmington, Ohio, United States

Greene Memorial Hospital, Xenia, Ohio, United States

Genesis Healthcare System Cancer Care Center, Zanesville, Ohio, United States

Clackamas Radiation Oncology Center, Clackamas, Oregon, United States

Providence Milwaukie Hospital, Milwaukie, Oregon, United States

Providence Newberg Medical Center, Newberg, Oregon, United States

Providence Willamette Falls Medical Center, Oregon City, Oregon, United States

Providence Portland Medical Center, Portland, Oregon, United States

Adventist Medical Center, Portland, Oregon, United States

Providence Saint Vincent Medical Center, Portland, Oregon, United States

Abington Memorial Hospital, Abington, Pennsylvania, United States

Lehigh Valley Hospital-Cedar Crest, Allentown, Pennsylvania, United States

Butler Memorial Hospital, Butler, Pennsylvania, United States

Geisinger Medical Center, Danville, Pennsylvania, United States

Geisinger Medical Center-Cancer Center Hazleton, Hazleton, Pennsylvania, United States

Geisinger Medical Group, State College, Pennsylvania, United States

Mount Nittany Medical Center, State College, Pennsylvania, United States

Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre, Pennsylvania, United States

McLeod Regional Medical Center, Florence, South Carolina, United States

Avera Cancer Institute-Aberdeen, Aberdeen, South Dakota, United States

Sanford Cancer Center Oncology Clinic, Sioux Falls, South Dakota, United States

Sanford NCI Community Oncology Research Program of the North Central Plains, Sioux Falls, South Dakota, United States

Avera Cancer Institute, Sioux Falls, South Dakota, United States

Avera McKennan Hospital and University Health Center, Sioux Falls, South Dakota, United States

Medical X-Ray Center, Sioux Falls, South Dakota, United States

Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota, United States

Wellmont Holston Valley Hospital and Medical Center, Kingsport, Tennessee, United States

Thompson Cancer Survival Center, Knoxville, Tennessee, United States

University of Tennessee - Knoxville, Knoxville, Tennessee, United States

The Don and Sybil Harrington Cancer Center, Amarillo, Texas, United States

Medical City Dallas Hospital, Dallas, Texas, United States

Danville Regional Medical Center, Danville, Virginia, United States

Fredericksburg Oncology Inc, Fredericksburg, Virginia, United States

Sovah Health Martinsville, Martinsville, Virginia, United States

Southwest VA Regional Cancer Center, Norton, Virginia, United States

Cancer Care Center at Island Hospital, Anacortes, Washington, United States

Overlake Hospital Medical Center, Bellevue, Washington, United States

PeaceHealth Saint Joseph Medical Center, Bellingham, Washington, United States

Harrison HealthPartners Hematology and Oncology-Bremerton, Bremerton, Washington, United States

Highline Medical Center-Main Campus, Burien, Washington, United States

Providence Regional Cancer System-Centralia, Centralia, Washington, United States

Providence Regional Cancer Partnership, Everett, Washington, United States

Saint Francis Hospital, Federal Way, Washington, United States

Kadlec Clinic Hematology and Oncology, Kennewick, Washington, United States

Saint Clare Hospital, Lakewood, Washington, United States

Skagit Valley Hospital, Mount Vernon, Washington, United States

Providence - Saint Peter Hospital, Olympia, Washington, United States

Harrison HealthPartners Hematology and Oncology-Poulsbo, Poulsbo, Washington, United States

MultiCare Good Samaritan Hospital, Puyallup, Washington, United States

Harborview Medical Center, Seattle, Washington, United States

Minor and James Medical PLLC, Seattle, Washington, United States

Fred Hutchinson Cancer Research Center, Seattle, Washington, United States

Kaiser Permanente Washington, Seattle, Washington, United States

Swedish Medical Center-First Hill, Seattle, Washington, United States

University of Washington Medical Center, Seattle, Washington, United States

PeaceHealth United General Medical Center, Sedro-Woolley, Washington, United States

Cancer Care Northwest - Spokane South, Spokane, Washington, United States

Evergreen Hematology and Oncology PS, Spokane, Washington, United States

MultiCare Allenmore Hospital, Tacoma, Washington, United States

MultiCare Tacoma General Hospital, Tacoma, Washington, United States

Northwest NCI Community Oncology Research Program, Tacoma, Washington, United States

Saint Joseph Medical Center, Tacoma, Washington, United States

PeaceHealth Southwest Medical Center, Vancouver, Washington, United States

Wenatchee Valley Hospital and Clinics, Wenatchee, Washington, United States

Edwards Comprehensive Cancer Center, Huntington, West Virginia, United States

Aurora Cancer Care-Southern Lakes VLCC, Burlington, Wisconsin, United States

Aurora Cancer Care-Franklin, Franklin, Wisconsin, United States

Aurora Health Care Germantown Health Center, Germantown, Wisconsin, United States

Aurora Cancer Care-Glendale, Glendale, Wisconsin, United States

Green Bay Oncology at Saint Vincent Hospital, Green Bay, Wisconsin, United States

Saint Vincent Hospital Cancer Center Green Bay, Green Bay, Wisconsin, United States

Green Bay Oncology Limited at Saint Mary's Hospital, Green Bay, Wisconsin, United States

Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay, Wisconsin, United States

Aurora Cancer Care-Kenosha South, Kenosha, Wisconsin, United States

Gundersen Lutheran Medical Center, La Crosse, Wisconsin, United States

Holy Family Memorial Hospital, Manitowoc, Wisconsin, United States

Bay Area Medical Center, Marinette, Wisconsin, United States

Aurora Saint Luke's Medical Center, Milwaukee, Wisconsin, United States

Saint Vincent Hospital Cancer Center at Oconto Falls, Oconto Falls, Wisconsin, United States

Aurora Cancer Care-Racine, Racine, Wisconsin, United States

HSHS Saint Nicholas Hospital, Sheboygan, Wisconsin, United States

Saint Vincent Hospital Cancer Center at Sturgeon Bay, Sturgeon Bay, Wisconsin, United States

Green Bay Oncology - Sturgeon Bay, Sturgeon Bay, Wisconsin, United States

Aurora Cancer Care-Waukesha, Waukesha, Wisconsin, United States

Aurora Cancer Care-Milwaukee West, Wauwatosa, Wisconsin, United States

Rocky Mountain Oncology, Casper, Wyoming, United States

Welch Cancer Center, Sheridan, Wyoming, United States

Contact Details

Name: Tufia C Haddad

Affiliation: Alliance for Clinical Trials in Oncology

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

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