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Spots Global Cancer Trial Database for MRI in High-Grade Glioma Patients Undergoing Chemoradiation

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We do not endorse or review these studies in any way.

Trial Identification

Brief Title: MRI in High-Grade Glioma Patients Undergoing Chemoradiation

Official Title: A Feasibility Study of Interim PET-MRI in High-grade Glioma Patients Undergoing Chemoradiation

Study ID: NCT05212272

Study Description

Brief Summary: The purpose of this research study is to see if investigators can predict how brain functioning changes after radiation treatment based on PET scans and blood tests. Most participants experience at least mild decreases in their memory or attention after radiation therapy. Investigators hope that PET scans, lumbar puncture, and blood tests might help investigators predict who might have larger changes in their brain function after radiation.

Detailed Description: Primary Objective: To determine the feasibility of interim PET-MRI in high-grade glioma patients undergoing chemoradiation by quantifying the proportion of high-grade glioma patients who are alive at 4 months post-radiation treatment and who have completed two PET scans and abbreviated cognitive testing pre-radiation treatment and at 4 months post radiation treatment. Secondary Objectives * To determine by machine learning if early changes on FDG-PET correlate with cognitive decline after radiation treatment. Cognitive impairment will be defined as a 1 standard deviation decline on any test. * To determine if baseline serum or cerebrospinal fluid markers or the change from baseline to 1-month are associated with patients with cognitive decline at 4-months after radiation treatment (defined as a 1 standard deviation decline on any test) compared to those without decline.

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, North Carolina, United States

Contact Details

Name: Christina Cramer, MD

Affiliation: Wake Forest Baptist Comprehensive Cancer Center

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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