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Brief Title: Cabozantinib in High Grade Neuroendocrine Neoplasms
Official Title: Cabozantinib in High Grade Neuroendocrine Neoplasms
Study ID: NCT04412629
Brief Summary: High grade neuroendocrine neoplasm patients are treated with platinum doublets such as carboplatin and etoposide mimicking the current guidelines for small cell lung cancer (SCLC). Unfortunately, recurrences are common and most patients with metastatic disease succumb to it within a year. There is no extensive literature or consensus on second- or third-line options (which include FOLFOX, FOLFIRI, capecitabine and temozolomide, taxanes or immunotherapy) and there is urgent need for better regimens.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Washington University School of Medicine, Saint Louis, Missouri, United States
Name: Nikolaos Trikalinos, M.D.
Affiliation: Washington University School of Medicine
Role: PRINCIPAL_INVESTIGATOR