Spots Global Cancer Trial Database for Cohort of HIV Associated Lymphomas
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Trial Identification
Brief Title: Cohort of HIV Associated Lymphomas
Official Title: French Cohort of HIV Associated Lymphomas
Study ID: NCT01164436
Conditions
Interventions
Study Description
Brief Summary: The incidence of lymphomas is increased among HIV infected patients. In 70 % of cases, those are Non Hodgkin's lymphomas (NHL) and Hodgkin lymphomas (HL) in 30% of cases. In France, their incidence is estimated to 100 cases per year (data from the "Base de données Hospitalière Française sur l'Infection à VIH" (FHDH)). The main mechanisms involved in lymphomagenesis are immune dysfunction, involvement of oncogenic viruses (Epstein-Barr (EBV) and HHV8) and molecular oncogenic events. A better understanding of these different pathways, give the possibility to design specific treatments. The treatment of these lymphomas is not standardized. A prospective study of patients with HIV associated lymphoid malignancies is an innovating tool to answer epidemiological, physiopathological and therapeutic questions. We propose a prospective multicentric study of these patients. The main objectives of this prospective study are to: * evaluate the incidence, characterise clinically and histologically NHL and HL cases associated to HIV * perform an observational study of the treatment and outcome of these patients out of the context of clinical trials, * study the differentiation and activation of B-cell populations, * better understand the role of specific T cell responses in the control of EBV infection, * allow other biological studies from the ANRS group " Lymphome et VIH ". The recruitment of 40 cases per year is expected. The length of inclusions is 7 years. The follow-up will be of 2 years. Clinical, pathological and biological data at diagnosis and during follow-up will be collected. This will allow characterizing the lymphoma, the HIV infection, the antitumoral treatments and the outcome of lymphoma. Biological samples will be centralized to collect cell, DNA, RNA, plasma, serum and tumour collections (Y.Taoufik, S Prevot\* ). To better understand the EBV infection and lymphomagenesis in HIV infection, we propose to follow the viral load and the molecular characteristics of EBV in PBMC, plasma and tumour (P.Morand\* , V.Boyer\* ), to investigate the EBV-T cell responses (G.Carcelain) and the presence and reactivation of EBV in peripheral B cells (C.Amiel\* , JC Nicolas) and in tumoral samples (M.Raphael\* , I.Joab\* ). The other mechanisms of lymphomagenesis in HIV infection will be studied by the analysis of the sub-populations of B-cells in terms of activation and differentiation (Y.Taoufik) and by the characterization of MSI tumours (A.Duval).
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
BESSON, Paris, , France
Contact Details
Name: Caroline BESSON
Affiliation: Service Hématologie Immunologie Biologie, Hopital Bicetre
Role: PRINCIPAL_INVESTIGATOR
Name: Gilles Pialoux, PH
Affiliation: Hôpital Tenon Paris
Role: PRINCIPAL_INVESTIGATOR
Name: Marie Caroline Meyonas, PH
Affiliation: Hôpital St Antoine Paris
Role: PRINCIPAL_INVESTIGATOR
Name: Christine Katlama, PH
Affiliation: Hôpital Pitiè Salpétrière
Role: PRINCIPAL_INVESTIGATOR
Name: Jean Gabarre, MD
Affiliation: Hôpital Pitiè Salpétrière Paris
Role: PRINCIPAL_INVESTIGATOR
Name: Dominique Salmon, PH
Affiliation: Hôpital Cochin PARIS
Role: PRINCIPAL_INVESTIGATOR
Name: François Dreyfus, PH
Affiliation: Hôpital Cochin Paris
Role: PRINCIPAL_INVESTIGATOR
Name: Jean Paul Viard, PH
Affiliation: Hotel Dieu PARIS
Role: PRINCIPAL_INVESTIGATOR
Name: Alain Devidas, PH
Affiliation: Corbeil Essone 91
Role: PRINCIPAL_INVESTIGATOR
Name: Emma Goldschmidt, MD
Affiliation: Villejuif 94
Role: PRINCIPAL_INVESTIGATOR
Name: Cecile Goujard, MD
Affiliation: Hôpital Bicêtre 94
Role: PRINCIPAL_INVESTIGATOR
Name: Laurent Blum, MD
Affiliation: Pointoise 95
Role: PRINCIPAL_INVESTIGATOR
Name: François Boué, PH
Affiliation: Clamart 92
Role: PRINCIPAL_INVESTIGATOR
Name: Eric Rosenthal, MD
Affiliation: Nice 06
Role: PRINCIPAL_INVESTIGATOR
Name: Christine Burty, MD
Affiliation: Vandoeuvre les Nancy 54
Role: PRINCIPAL_INVESTIGATOR
Name: Jean Marie Lang, PH
Affiliation: Strasbourg 67
Role: PRINCIPAL_INVESTIGATOR
Name: Renaud Verdon, PH
Affiliation: Caen 14
Role: PRINCIPAL_INVESTIGATOR
Name: Yazdan Yazdanpanah, PH
Affiliation: Tourcoing 59
Role: PRINCIPAL_INVESTIGATOR
Name: Christine Drobacheff, MD
Affiliation: Besancon 25
Role: PRINCIPAL_INVESTIGATOR
Name: Bruno Marchou, PH
Affiliation: Toulouse 31
Role: PRINCIPAL_INVESTIGATOR
Name: Corinne Couteau, MD
Affiliation: Toulouse 31
Role: PRINCIPAL_INVESTIGATOR
Name: Philippe Morlat, PH
Affiliation: Bordeaux 33
Role: PRINCIPAL_INVESTIGATOR
Name: Christian Trepo, PH
Affiliation: Lyon 69
Role: PRINCIPAL_INVESTIGATOR
Name: Hervé Ghesquières, PH
Affiliation: Lyon 69
Role: PRINCIPAL_INVESTIGATOR
Name: Régis Costellos, PH
Affiliation: Marseille
Role: PRINCIPAL_INVESTIGATOR
Name: Bertrand Coiffier, Ph
Affiliation: Pierre Bénite
Role: PRINCIPAL_INVESTIGATOR
Name: Claude Beuscart, MD
Affiliation: St Brieuc 22
Role: PRINCIPAL_INVESTIGATOR
Name: Philippe Perre, MD
Affiliation: La Roche Sur Yon 85
Role: PRINCIPAL_INVESTIGATOR
Name: Patrice Poubeau, MD
Affiliation: St Pierre 97
Role: PRINCIPAL_INVESTIGATOR
Name: François Raffi, PH
Affiliation: Nantes 44
Role: PRINCIPAL_INVESTIGATOR
Name: Frédéric Lucht, PH
Affiliation: St Etienne 42
Role: PRINCIPAL_INVESTIGATOR
Name: Nicolas Mounier, PH
Affiliation: Nice 06
Role: PRINCIPAL_INVESTIGATOR
Name: Cédric Arvieux, PH
Affiliation: Rennes 35
Role: PRINCIPAL_INVESTIGATOR
Name: Serge Herson, PH
Affiliation: Pitié Salpétrière Paris
Role: PRINCIPAL_INVESTIGATOR
Name: Jean François Bergmann, PH
Affiliation: Lariboisière Paris
Role: PRINCIPAL_INVESTIGATOR
Name: André Cabié, PH
Affiliation: Fort de France 97( Martinique)
Role: PRINCIPAL_INVESTIGATOR
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