Neoplasms

Blood and Lymph Conditions

Immune System Diseases

All Conditions

Rare Diseases

Lymphoma

Hodgkin Disease

Neoplasms by Histologic Type

Lymphoproliferative Disorders

Lymphatic Diseases

Immunoproliferative Disorders

Lymphosarcoma

Hodgkin Lymphoma

Proton Radiation Plan

Conventional Photon Radiation Plan

Intensity Modulated Radiation Plan

Bradford S Hoppe, MD, MPH

The purpose of this study is to reduce the risk of radiation related side effects and complications by treating with radiation (protons or photons) that exposes less of normal organs to low dose radiation.

3 treatment plans will be created to deliver between a total of 21-39.6 Gray (Gy)/Centigray Equivalents (CGE) to the planning target volume (PTV).

1. Proton Plan
2. Conventional Plan
3. Intensity Modulated Radiotherapy (IMRT) Plan

The patient will then receive the radiation modality with the lowest percentage of the body receiving 4 Gy (V4Gy/CGE)

Proton Therapy for Hodgkin Lymphoma

Improving the Therapeutic Ratio by Using Proton Beam Radiation Therapy for Patients With Stage IA-IIIBX (Bulky/Non-bulky) Hodgkin Lymphoma Involving the Mediastinum Following Standard Chemotherapy

Overall survival as assessed with the Kaplan-Meier product limit method.

Disease free survival as assessed with the Kaplan-Meier product limit method

University of Florida

There were 20 patients initially enrolled. One decided to not receive treatment after initial enrollment. Three had treatment plans completed (and thus contributed that data), but sought treatment elsewhere. One patient was withdrawn after treatment. There are therefore only 15 of 20 enrolled patients actually assessable for adverse events.

Each patient has three radiation treatment plans conducted prior to initiation of treatment (proton, IMRT, conventional). Only the plan that's found to be the most optimal in regard to minimizing the heart v4 is the one that was actually used to treat the patient. In this case, the proton plan was found to be the optimal plan in each case; patients were therefore treated with proton therapy between 21-39.6 Gray (Gy)/Centigray Equivalents (CGE) to the planning target volume (PTV).

The primary endpoint of this study is the paired differences among the three plans. Thus there's just one treatment arm.

Superior Treatment Plan

Each patient has a proton, IMRT and conventional plan done prior to treatment for dosimetric comparison of the primary endpoint which is the percent of the body that receives 4 Gray (%V4). The plan that delivers the smallest %V4 will be the plan that is pursued for actual treatment. Therefore, each patient will have three treatment plans, but will only be treated with one of these three plans (the superior one).

Proton Therapy Plan Compared to IMRT and Conventional RT

Age, Categorical

Age, Continuous

Sex: Female, Male

United States

Region of Enrollment

20 patients were enrolled. One decided to withdrawal after being enrolled, but prior to any treatment plans being performed.

Bradford Hoppe, MD, MPH

Proton Radiation Plan: Between 21-39.6 Gy/CGE to the PTV

Conventional Photon Radiation Plan: Between 21-39.6 Gy/CGE to the PTV

Intensity Modulated Radiation Plan: Between 21-39.6 Gy/CGE to the PTV

Comparison of Normal Tissue Exposed to Greater Than or Equal to 4 Gy/CGE With Use of Proton Therapy Compared to Both Intensity Modulated Radiotherapy (IMRT) and Conventional Therapy.

Overall survival as estimated with the Kaplan-Meier product limit method at 4 years after treatment.

Spots Global Cancer Trial Database for Proton Therapy for Hodgkin Lymphoma

Trial Identification

Conditions

Interventions

Study Description

Keywords

Eligibility

Locations

Contact Details

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