Spots Global Cancer Trial Database for Effect of Longer-term Adrenal Suppression Using Low Dose Hydrocortisone on Androgen Overproduction
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Trial Identification
Brief Title: Effect of Longer-term Adrenal Suppression Using Low Dose Hydrocortisone on Androgen Overproduction
Official Title: Effect of Longer-term Adrenal Suppression Using Low Dose Hydrocortisone on Androgen Overproduction in Overweight Early Pubertal Girls With Androgen Excess (CBS0004)
Study ID: NCT01422733
Study Description
Brief Summary: This study will test whether longer-term suppression of adrenal function can ameliorate androgen (male hormone) overproduction in overweight early pubertal girls with androgen excess. The investigators hypothesize that suppression of nighttime adrenocorticotropin hormone (ACTH) production by 12 weeks of evening oral hydrocortisone administration will improve androgen levels in girls with adrenal androgen overproduction. Specifically, this intervention will improve androgen levels after adrenal stimulation testing with ACTH or ovarian stimulation testing with recombinant human chorionic gonadotropin (rhCG).
Detailed Description:
Keywords
Eligibility
Minimum Age: 7 Years
Eligible Ages: CHILD
Sex: FEMALE
Healthy Volunteers: No
Locations
University of Virginia Center for Research in Reproduction, Charlottesville, Virginia, United States
Contact Details
Name: Christine Burt Solorzano, MD
Affiliation: University of Virginia
Role: PRINCIPAL_INVESTIGATOR
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