Neoplasms

All Conditions

Gland and Hormone Related Diseases

Rare Diseases

Adenoma

Hyperparathyroidism

Hyperparathyroidism, Primary

Parathyroid Neoplasms

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Parathyroid Diseases

Endocrine System Diseases

Endocrine Gland Neoplasms

Head and Neck Neoplasms

Primary Hyperparathyroidism

All Drugs and Chemicals

Parathyroid Hormone

Patients will undergo a single fluorocholine PET imaging study prior to surgery.

18F-Fluorocholine

Imaging technique that uses radioactive agents known as radiotracers to visualize and measure changes in metabolic processes, and in other physiological activities

Positron Emission Tomography (PET)

Thomas Hope, MD

The investigators are studying the ability of F18 labeled fluorocholine PET to localize parathyroid adenomas in patients with hyperparathyroidism prior to surgery.

18F-Fluorocholine for the Detection of Parathyroid Adenomas

The true positive (sensitivity) rate is defined as the proportion of participants with location of the suspected adenoma on 18F-Fluorocholine PET correlating with location of an abnormal parathyroid at time of participant surgery. For a patient with multiple hyperplastic glands, only one gland needs to correlate for the patient to count as a true positive. For analysis, adenomas described as arising in the mid thyroid bed will considered correct if located in either the inferior or superior bed. Patients will be followed-up to determine if they undergo a parathyroidectomy for up to 1 year.

The true positive (sensitivity) rate is defined as the proportion of participants with location of the suspected adenoma on 18F-Fluorocholine PET correlating with location of an abnormal parathyroid at time of participant surgery. For a patient with multiple hyperplastic glands, only one gland needs to correlate for the patient to count as a true positive. In patients who had a sestamibi study performed prior to the fluorocholine imaging study, the original dictated report from the sestamibi will be used for comparison. For analysis, adenomas described as arising in the mid thyroid bed will considered correct if located in either the inferior or superior bed. Patients will be followed-up to determine if they undergo a parathyroidectomy for up to 1 year.

The detection rate is defined as the proportion of participants with a 18F-fluorocholine PET positive read who do not subsequently undergo parathyroidectomy, using the dictated reports to determine the detection sensitivity for parathyroid adenomas. Patients will be followed-up to determine if they undergo a parathyroidectomy for up to 1 year.

Thomas Hope

Associate Professor, Radiology

Patients will undergo a single fluorocholine PET imaging study prior to surgery.

18F-Fluorocholine: Given intravenously

Positron Emission Tomography (PET): Imaging technique that uses radioactive agents known as radiotracers to visualize and measure changes in metabolic processes, and in other physiological activities

18F-Fluorocholine PET

Age, Continuous

Sex: Female, Male

Ethnicity (NIH/OMB)

Race (NIH/OMB)

United States

Region of Enrollment

Prior History of Parathyroidectomy at Baseline

Dr. Thomas A. Hope, MD

Proportion of True Positives for the Overall Detection of the Abnormal Parathyroid Adenoma

Only 66 of the 77 participants who underwent surgery had an available sestamibi study

Proportion of True Positives for the Detection of the Abnormal Parathyroid Adenoma Using Sestamibi Imaging

Detection Rate in Patients Who Have Not Undergone Surgical Resection

Overall Study

Spots Global Cancer Trial Database for 18F-Fluorocholine for the Detection of Parathyroid Adenomas

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Interventions

Study Description

Keywords

Eligibility

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