Spots Global Cancer Trial Database for Bristol Bladder Trial
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Trial Identification
Brief Title: Bristol Bladder Trial
Official Title: A Phase II Trial of Combination Cabazitaxel and Cisplatin Chemotherapy in the Neo-adjuvant Treatment of Transitional Cell Carcinoma of the Urinary Bladder
Study ID: NCT01616875
Interventions
Study Description
Brief Summary: 26 patients with invasive primary transitional cell carcinoma of the bladder will receive 4 cycles of combination chemotherapy consisting of Cabazitaxel and Cisplatin both given intravenously on day 1 of each 3 weekly cycle prior to radical cystectomy, to evaluate the overall response rate and to determine whether this approach warrants further research of a phase II/III study.Participation in 2 sub studies will also be offered to the participants. 1. Contrast Magnetic resonance imaging (MRI ) scans will be taken at baseline and after cycle 1 and cycle 3. 2. A pilot sub study involving the circulating tumour cell concentration from blood samples taken at baseline, prior to each cycle of chemotherapy and prior to surgery
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Bristol Haematology + Oncology Centre, Horfield Road, Bristol, , United Kingdom
Contact Details
Name: Amit K Bahl
Affiliation: University Hospitals Bristol and Weston NHS Foundation Trust
Role: PRINCIPAL_INVESTIGATOR
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