Spots Global Cancer Trial Database for Treatment Outcomes of Advanced Neoplasia in IBD

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Trial Identification

Brief Title: Treatment Outcomes of Advanced Neoplasia in IBD

Official Title: Endoscopic and Surgical Treatment Outcomes of Colitis-associated Advanced Neoplasia: a Multicenter Cohort Study

Study ID: NCT05674773

Conditions

Inflammatory Bowel Diseases

Interventions

Endoscopic or surgical resection

Study Description

Brief Summary: In this study, we aimed to (1) compare cumulative incidences of synchronous and metachronous colorectal neoplasia as well as mortality following AN in CD and UC patients who underwent proctocolectomy, (sub)total colectomy, partial colectomy or endoscopic resection, and (2) to determine factors associated with AN treatment choice.

Detailed Description: In this retrospective multicenter cohort study, using PALGA (the Dutch nationwide pathology databank), partial colectomy yielded a similar metachronous neoplasia risk compared to (sub)total colectomy after treatment of advanced neoplasia in inflammatory bowel disease. High metachronous neoplasia rates after endoscopic resection underline the importance of strict subsequent endoscopic surveillance.