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Spots Global Cancer Trial Database for Tamoxifen Citrate or Letrozole With or Without Bevacizumab in Treating Women With Stage IIIB or Stage IV Breast Cancer

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Tamoxifen Citrate or Letrozole With or Without Bevacizumab in Treating Women With Stage IIIB or Stage IV Breast Cancer

Official Title: Endocrine Therapy With or Without Anti-VEGF Therapy: A Randomized, Phase III Trial of Endocrine Therapy Alone or Endocrine Therapy Plus Bevacizumab (NSC 704865) for Women With Hormone Receptor-Positive Advanced Breast Cancer

Study ID: NCT00601900

Study Description

Brief Summary: This randomized phase III trial studies tamoxifen citrate or letrozole together with bevacizumab to see how well it works compared with tamoxifen citrate or letrozole alone in treating women with stage IIIB or stage IV breast cancer. Estrogen can cause the growth of breast cancer cells. Hormone therapy using tamoxifen citrate or letrozole may fight breast cancer by blocking the use of estrogen by the tumor cells. Immunotherapy with monoclonal antibodies, such as bevacizumab, may induce changes in the body's immune system and may interfere with the ability of tumor cells to grow and spread. It is not yet known whether giving hormone therapy is more effective with or without bevacizumab in treating advanced breast cancer.

Detailed Description: PRIMARY OBJECTIVES: I. To compare the progression-free survival of letrozole therapy alone with the combination of letrozole therapy plus bevacizumab as first-line treatment in women with estrogen- and/or progesterone-receptor-positive advanced breast cancer. SECONDARY OBJECTIVES: I. To compare the proportion of patients receiving letrozole alone, who remain progression-free at 6 and 12 months, to those receiving letrozole plus bevacizumab. II. To compare the incidence of objective response (complete response \[CR\] + partial response \[PR\]) in patients receiving letrozole with and without bevacizumab, as determined by Response Evaluation Criteria in Solid Tumors (RECIST) criteria, excluding patients with non-measurable disease. III. To compare the incidence of clinical benefit (CR + PR + stable disease \>= 6 months) in patients receiving letrozole with and without bevacizumab. IV. To compare the duration of objective response in patients receiving letrozole with and without bevacizumab. V. To compare the time to treatment failure in patients receiving letrozole with and without bevacizumab. VI. To compare the overall survival of patients receiving letrozole with and without bevacizumab, including the probability of survival until 36 months. VII. To compare toxicity levels between the bevacizumab arm and the arm without bevacizumab in both the letrozole-treated patients and in the tamoxifen-treated patients. VIII. To compare progression-free survival and overall survival of all patients receiving endocrine therapy with and without bevacizumab (by combining both letrozole and tamoxifen\* patient subgroups). CORRELATIVE OBJECTIVES: I. To compare baseline and changes in serial levels of circulating endothelial cells and circulating tumor cells in patients treated with endocrine therapy alone or endocrine therapy plus bevacizumab, and to explore the relationship of these markers with progression free survival. II. To conduct proteomic analysis of longitudinal samples from patients with advanced-stage disease undergoing hormonal therapy to define new serum-based biomarkers related to disease activity. III. To identify biologic correlates that will predict progression-free survival (PFS) and response to therapy. IV. To conduct pharmacogenomic assessment of candidate variants in the VEGF, CYP2D6, and CYP19 genes and evaluate their association with PFS and other study outcomes. V. To identify single nucleotide polymorphisms (SNPs) associated with progression free survival in the genome-wide approach (GWAS). VI. To identify factors other than chronological age that predict the risk of grade 3, 4 or 5 toxicity with bevacizumab and endocrine therapy by means of functional age assessment measures. VII. To perform an exploratory analysis of the ability of the other factors included in the functional age assessment (either individual or in combination), to predict the risk of grade 3, 4 or 5 toxicity. VIII. To evaluate longitudinal changes in the parameters of the factors described in objective VI while on therapy. OUTLINE: Patients are randomized to 1 of 2 treatment arms. NOTE: The placebo-controlled portion of the study was canceled on 5-15-10. ARM I: Patients receive endocrine therapy\* (tamoxifen citrate or letrozole) orally (PO) once daily (QD) on days 1-21 and bevacizumab intravenously (IV) over 30-90 minutes on day 1. Treatment repeats every 21 days in the absence of disease progression or unacceptable toxicity. ARM II: Patients receive endocrine therapy\* (tamoxifen citrate or letrozole) PO QD on days 1-21. Treatment repeats every 21 days in the absence of disease progression or unacceptable toxicity. After completion of study therapy, patients are followed up every 6 months for the first 2 years and then annually for up to 3 years. \* NOTE: As of 5/15/2011, patients only receive letrozole.

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: FEMALE

Healthy Volunteers: No

Locations

Providence Hospital, Mobile, Alabama, United States

Sparks Regional Medical Center, Fort Smith, Arkansas, United States

East Bay Medical Oncology Hematology Medical Associates-Antioch, Antioch, California, United States

Alta Bates Summit Medical Center-Herrick Campus, Berkeley, California, United States

Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank, California, United States

Mills-Peninsula Medical Center, Burlingame, California, United States

East Bay Radiation Oncology Center, Castro Valley, California, United States

Eden Hospital Medical Center, Castro Valley, California, United States

Valley Medical Oncology Consultants-Castro Valley, Castro Valley, California, United States

Adventist Health Cancer Care Center Chico, Chico, California, United States

Community Cancer Institute, Clovis, California, United States

Bay Area Breast Surgeons Inc, Emeryville, California, United States

Valley Medical Oncology Consultants-Fremont, Fremont, California, United States

Marin General Hospital, Greenbrae, California, United States

Los Angeles General Medical Center, Los Angeles, California, United States

USC / Norris Comprehensive Cancer Center, Los Angeles, California, United States

Contra Costa Regional Medical Center, Martinez, California, United States

Fremont - Rideout Cancer Center, Marysville, California, United States

Memorial Medical Center, Modesto, California, United States

El Camino Hospital, Mountain View, California, United States

Sutter Cancer Research Consortium, Novato, California, United States

Highland General Hospital, Oakland, California, United States

Alta Bates Summit Medical Center - Summit Campus, Oakland, California, United States

Bay Area Tumor Institute, Oakland, California, United States

Hematology and Oncology Associates-Oakland, Oakland, California, United States

Tom K Lee Inc, Oakland, California, United States

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange, California, United States

East Bay Medical Oncology Hematology Medical Associates Inc-Pleasant Hill, Pleasant Hill, California, United States

John Muir Health Cancer Medical Group, Pleasant Hill, California, United States

Valley Care Health System - Pleasanton, Pleasanton, California, United States

Valley Medical Oncology Consultants, Pleasanton, California, United States

Pomona Valley Hospital Medical Center, Pomona, California, United States

University of California Davis Comprehensive Cancer Center, Sacramento, California, United States

Saint Helena Hospital, Saint Helena, California, United States

Zuckerberg San Francisco General Hospital, San Francisco, California, United States

California Pacific Medical Center-Pacific Campus, San Francisco, California, United States

UCSF Medical Center-Mount Zion, San Francisco, California, United States

East Bay Medical Oncology Hematology Associates Inc, San Leandro, California, United States

Doctors Medical Center- JC Robinson Regional Cancer Center, San Pablo, California, United States

Gene Upshaw Memorial Tahoe Forest Cancer Center, Truckee, California, United States

Northbay Cancer Center, Vacaville, California, United States

Sutter Solano Medical Center/Cancer Center, Vallejo, California, United States

The Medical Center of Aurora, Aurora, Colorado, United States

Boulder Community Hospital, Boulder, Colorado, United States

Penrose-Saint Francis Healthcare, Colorado Springs, Colorado, United States

Porter Adventist Hospital, Denver, Colorado, United States

Presbyterian - Saint Lukes Medical Center - Health One, Denver, Colorado, United States

SCL Health Saint Joseph Hospital, Denver, Colorado, United States

Rose Medical Center, Denver, Colorado, United States

Western States Cancer Research NCORP, Denver, Colorado, United States

Swedish Medical Center, Englewood, Colorado, United States

Poudre Valley Hospital, Fort Collins, Colorado, United States

Saint Mary's Hospital and Regional Medical Center, Grand Junction, Colorado, United States

Banner North Colorado Medical Center, Greeley, Colorado, United States

Saint Anthony Hospital, Lakewood, Colorado, United States

Littleton Adventist Hospital, Littleton, Colorado, United States

Sky Ridge Medical Center, Lone Tree, Colorado, United States

Longmont United Hospital, Longmont, Colorado, United States

Banner McKee Medical Center, Loveland, Colorado, United States

Saint Mary Corwin Medical Center, Pueblo, Colorado, United States

North Suburban Medical Center, Thornton, Colorado, United States

SCL Health Lutheran Medical Center, Wheat Ridge, Colorado, United States

Hartford Hospital, Hartford, Connecticut, United States

Smilow Cancer Hospital Care Center at Saint Francis, Hartford, Connecticut, United States

Middlesex Hospital, Middletown, Connecticut, United States

The Hospital of Central Connecticut, New Britain, Connecticut, United States

Yale University, New Haven, Connecticut, United States

Stamford Hospital/Bennett Cancer Center, Stamford, Connecticut, United States

Beebe Medical Center, Lewes, Delaware, United States

Christiana Care Health System-Christiana Hospital, Newark, Delaware, United States

Sibley Memorial Hospital, Washington, District of Columbia, United States

Boca Raton Regional Hospital, Boca Raton, Florida, United States

Holy Cross Hospital, Fort Lauderdale, Florida, United States

Florida Cancer Specialists-Gainesville Cancer Center, Gainesville, Florida, United States

Jupiter Medical Center, Jupiter, Florida, United States

Mount Sinai Medical Center, Miami Beach, Florida, United States

University Cancer and Blood Center LLC, Athens, Georgia, United States

Piedmont Hospital, Atlanta, Georgia, United States

Atlanta Regional CCOP, Atlanta, Georgia, United States

Emory Saint Joseph's Hospital, Atlanta, Georgia, United States

Northside Hospital, Atlanta, Georgia, United States

Augusta University Medical Center, Augusta, Georgia, United States

WellStar Cobb Hospital, Austell, Georgia, United States

John B Amos Cancer Center, Columbus, Georgia, United States

Dekalb Medical Center, Decatur, Georgia, United States

Dublin Hematology Oncology Care PC, Dublin, Georgia, United States

Piedmont Fayette Hospital, Fayetteville, Georgia, United States

Eisenhower Army Medical Center, Fort Gordon, Georgia, United States

Northeast Georgia Medical Center-Gainesville, Gainesville, Georgia, United States

Northside Hospital - Gwinnett, Lawrenceville, Georgia, United States

Atrium Health Navicent, Macon, Georgia, United States

Wellstar Kennestone Hospital, Marietta, Georgia, United States

Southern Regional Medical Center, Riverdale, Georgia, United States

Harbin Clinic Medical Oncology and Clinical Research, Rome, Georgia, United States

Pali Momi Medical Center, 'Aiea, Hawaii, United States

Hawaii Cancer Care Inc - Waterfront Plaza, Honolulu, Hawaii, United States

Queen's Medical Center, Honolulu, Hawaii, United States

Straub Clinic and Hospital, Honolulu, Hawaii, United States

University of Hawaii Cancer Center, Honolulu, Hawaii, United States

Queen's Cancer Center - Kuakini, Honolulu, Hawaii, United States

The Cancer Center of Hawaii-Liliha, Honolulu, Hawaii, United States

Kapiolani Medical Center for Women and Children, Honolulu, Hawaii, United States

Maui Memorial Medical Center, Wailuku, Hawaii, United States

Pacific Cancer Institute of Maui, Wailuku, Hawaii, United States

Saint Anthony's Health, Alton, Illinois, United States

Rush - Copley Medical Center, Aurora, Illinois, United States

OSF Saint Joseph Medical Center, Bloomington, Illinois, United States

Illinois CancerCare-Bloomington, Bloomington, Illinois, United States

Graham Hospital Association, Canton, Illinois, United States

Illinois CancerCare-Canton, Canton, Illinois, United States

Illinois CancerCare-Carthage, Carthage, Illinois, United States

Memorial Hospital, Carthage, Illinois, United States

Mount Sinai Hospital Medical Center, Chicago, Illinois, United States

John H Stroger Jr Hospital of Cook County, Chicago, Illinois, United States

Mercy Hospital and Medical Center, Chicago, Illinois, United States

Presence Resurrection Medical Center, Chicago, Illinois, United States

University of Chicago Comprehensive Cancer Center, Chicago, Illinois, United States

Advocate Illinois Masonic Medical Center, Chicago, Illinois, United States

Decatur Memorial Hospital, Decatur, Illinois, United States

Heartland Cancer Research NCORP, Decatur, Illinois, United States

Advocate Good Samaritan Hospital, Downers Grove, Illinois, United States

Ascension Alexian Brothers - Elk Grove Village, Elk Grove Village, Illinois, United States

Elmhurst Memorial Hospital, Elmhurst, Illinois, United States

Eureka Hospital, Eureka, Illinois, United States

Illinois CancerCare-Eureka, Eureka, Illinois, United States

Freeport Memorial Hospital/Leonard C Ferguson Cancer Center, Freeport, Illinois, United States

Illinois CancerCare-Galesburg, Galesburg, Illinois, United States

Ingalls Memorial Hospital, Harvey, Illinois, United States

Illinois CancerCare-Havana, Havana, Illinois, United States

Mason District Hospital, Havana, Illinois, United States

Duly Health and Care Joliet, Joliet, Illinois, United States

Presence Saint Mary's Hospital, Kankakee, Illinois, United States

Illinois CancerCare-Kewanee Clinic, Kewanee, Illinois, United States

AMITA Health Adventist Medical Center, La Grange, Illinois, United States

Illinois CancerCare-Macomb, Macomb, Illinois, United States

Mcdonough District Hospital, Macomb, Illinois, United States

Garneau, Stewart C MD (UIA Investigator), Moline, Illinois, United States

Porubcin, Michael MD (UIA Investigator), Moline, Illinois, United States

Sharis, Christine M MD (UIA Investigator), Moline, Illinois, United States

Spector, David MD (UIA Investigator), Moline, Illinois, United States

Stoffel, Thomas J MD (UIA Investigator), Moline, Illinois, United States

Trinity Medical Center, Moline, Illinois, United States

Holy Family Medical Center, Monmouth, Illinois, United States

Illinois CancerCare-Monmouth, Monmouth, Illinois, United States

Good Samaritan Regional Health Center, Mount Vernon, Illinois, United States

Bromenn Regional Medical Center, Normal, Illinois, United States

Carle Cancer Institute Normal, Normal, Illinois, United States

Illinois CancerCare-Community Cancer Center, Normal, Illinois, United States

Illinois CancerCare-Ottawa Clinic, Ottawa, Illinois, United States

Ottawa Regional Hospital and Healthcare Center, Ottawa, Illinois, United States

Illinois CancerCare-Pekin, Pekin, Illinois, United States

OSF Saint Francis Radiation Oncology at Pekin, Pekin, Illinois, United States

Proctor Hospital, Peoria, Illinois, United States

Illinois CancerCare-Peoria, Peoria, Illinois, United States

Methodist Medical Center of Illinois, Peoria, Illinois, United States

OSF Saint Francis Medical Center, Peoria, Illinois, United States

Illinois CancerCare-Peru, Peru, Illinois, United States

Illinois Valley Hospital, Peru, Illinois, United States

Illinois CancerCare-Princeton, Princeton, Illinois, United States

Perry Memorial Hospital, Princeton, Illinois, United States

Illinois CancerCare-Spring Valley, Spring Valley, Illinois, United States

Memorial Medical Center, Springfield, Illinois, United States

Carle Cancer Center, Urbana, Illinois, United States

Franciscan Saint Francis Health-Beech Grove, Beech Grove, Indiana, United States

Elkhart Clinic, Elkhart, Indiana, United States

Michiana Hematology Oncology PC-Elkhart, Elkhart, Indiana, United States

Elkhart General Hospital, Elkhart, Indiana, United States

Fort Wayne Medical Oncology and Hematology Inc-Parkview, Fort Wayne, Indiana, United States

Ascension Saint Vincent Indianapolis Hospital, Indianapolis, Indiana, United States

Community Howard Regional Health, Kokomo, Indiana, United States

IU Health La Porte Hospital, La Porte, Indiana, United States

IU Health Arnett Cancer Care, Lafayette, Indiana, United States

Franciscan Saint Anthony Health-Michigan City, Michigan City, Indiana, United States

Michiana Hematology Oncology PC-Mishawaka, Mishawaka, Indiana, United States

Saint Joseph Regional Medical Center-Mishawaka, Mishawaka, Indiana, United States

Michiana Hematology Oncology PC-Plymouth, Plymouth, Indiana, United States

Reid Health, Richmond, Indiana, United States

Memorial Hospital of South Bend, South Bend, Indiana, United States

Michiana Hematology Oncology PC-South Bend, South Bend, Indiana, United States

Northern Indiana Cancer Research Consortium, South Bend, Indiana, United States

Michiana Hematology Oncology PC-Westville, Westville, Indiana, United States

McFarland Clinic - Ames, Ames, Iowa, United States

Constantinou, Costas L MD (UIA Investigator), Bettendorf, Iowa, United States

University of Iowa Healthcare Cancer Services Quad Cities, Bettendorf, Iowa, United States

Mission Cancer and Blood - West Des Moines, Clive, Iowa, United States

Mercy Capitol, Des Moines, Iowa, United States

Iowa Methodist Medical Center, Des Moines, Iowa, United States

Iowa-Wide Oncology Research Coalition NCORP, Des Moines, Iowa, United States

Mission Cancer and Blood - Des Moines, Des Moines, Iowa, United States

Mercy Medical Center - Des Moines, Des Moines, Iowa, United States

Mission Cancer and Blood - Laurel, Des Moines, Iowa, United States

Iowa Lutheran Hospital, Des Moines, Iowa, United States

University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa, United States

Ottumwa Regional Health Center, Ottumwa, Iowa, United States

Siouxland Regional Cancer Center, Sioux City, Iowa, United States

Mercy Medical Center-Sioux City, Sioux City, Iowa, United States

Saint Luke's Regional Medical Center, Sioux City, Iowa, United States

HaysMed, Hays, Kansas, United States

Hutchinson Regional Medical Center, Hutchinson, Kansas, United States

University of Kansas Cancer Center, Kansas City, Kansas, United States

Olathe Cancer Center, Olathe, Kansas, United States

Ascension Via Christi - Pittsburg, Pittsburg, Kansas, United States

Salina Regional Health Center, Salina, Kansas, United States

Cotton O'Neil Cancer Center / Stormont Vail Health, Topeka, Kansas, United States

University of Kansas Health System Saint Francis Campus, Topeka, Kansas, United States

Our Lady Bellefonte Hospital, Ashland, Kentucky, United States

Doctors Carrol, Sheth, Raghavan, Louisville, Kentucky, United States

Hematology/Oncology Clinic PLLC, Baton Rouge, Louisiana, United States

Mary Bird Perkins Cancer Center, Baton Rouge, Louisiana, United States

Ochsner Health Center-Summa, Baton Rouge, Louisiana, United States

Ochsner Health Center-Covington, Covington, Louisiana, United States

Louisiana State University Health Science Center, New Orleans, Louisiana, United States

Tulane University School of Medicine, New Orleans, Louisiana, United States

Ochsner Baptist Medical Center, New Orleans, Louisiana, United States

Ochsner Medical Center Jefferson, New Orleans, Louisiana, United States

Harold Alfond Center for Cancer Care, Augusta, Maine, United States

Eastern Maine Medical Center, Bangor, Maine, United States

Maine Center for Cancer Medicine-Scarborough, Scarborough, Maine, United States

University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland, United States

Veterans Administration Medical Center-Baltimore, Baltimore, Maryland, United States

Greater Baltimore Medical Center, Baltimore, Maryland, United States

Sinai Hospital of Baltimore, Baltimore, Maryland, United States

Christiana Care - Union Hospital, Elkton, Maryland, United States

Frederick Memorial Hospital, Frederick, Maryland, United States

Meritus Medical Center, Hagerstown, Maryland, United States

Kaiser Permanente - Largo Medical Center, Largo, Maryland, United States

Kaiser Permanente Lutherville - Timonium Medical Center, Lutherville, Maryland, United States

Kaiser Permanente - Shady Grove Medical Center, Rockville, Maryland, United States

Holy Cross Hospital, Silver Spring, Maryland, United States

Brigham and Women's Hospital, Boston, Massachusetts, United States

Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States

Dana-Farber Cancer Institute, Boston, Massachusetts, United States

Addison Gilbert Hospital, Gloucester, Massachusetts, United States

Cape Cod Hospital, Hyannis, Massachusetts, United States

Lowell General Hospital, Lowell, Massachusetts, United States

Holy Family Hospital, Methuen, Massachusetts, United States

Dana-Farber/Brigham and Women's Cancer Center at Milford Regional, Milford, Massachusetts, United States

Newton-Wellesley Hospital, Newton, Massachusetts, United States

Michigan Cancer Research Consortium NCORP, Ann Arbor, Michigan, United States

Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor, Michigan, United States

Bronson Battle Creek, Battle Creek, Michigan, United States

McLaren Cancer Institute-Bay City, Bay City, Michigan, United States

Spectrum Health Big Rapids Hospital, Big Rapids, Michigan, United States

Beaumont Hospital - Dearborn, Dearborn, Michigan, United States

Wayne State University/Karmanos Cancer Institute, Detroit, Michigan, United States

Ascension Saint John Hospital, Detroit, Michigan, United States

Michigan State University Clinical Center, East Lansing, Michigan, United States

OSF Saint Francis Hospital and Medical Group, Escanaba, Michigan, United States

Hurley Medical Center, Flint, Michigan, United States

Genesys Regional Medical Center-West Flint Campus, Flint, Michigan, United States

McLaren Cancer Institute-Flint, Flint, Michigan, United States

Cancer Research Consortium of West Michigan NCORP, Grand Rapids, Michigan, United States

Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids, Michigan, United States

Trinity Health Grand Rapids Hospital, Grand Rapids, Michigan, United States

Green Bay Oncology - Iron Mountain, Iron Mountain, Michigan, United States

Allegiance Health, Jackson, Michigan, United States

Bronson Methodist Hospital, Kalamazoo, Michigan, United States

West Michigan Cancer Center, Kalamazoo, Michigan, United States

Borgess Medical Center, Kalamazoo, Michigan, United States

Karmanos Cancer Institute at McLaren Greater Lansing, Lansing, Michigan, United States

University of Michigan Health - Sparrow Lansing, Lansing, Michigan, United States

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia, Michigan, United States

UP Health System Marquette, Marquette, Michigan, United States

MyMichigan Medical Center Midland, Midland, Michigan, United States

Mercy Health Partners-Hackley Campus, Muskegon, Michigan, United States

Trinity Health Muskegon Hospital, Muskegon, Michigan, United States

Corewell Health Lakeland Hospitals - Niles Hospital, Niles, Michigan, United States

McLaren Cancer Institute-Northern Michigan, Petoskey, Michigan, United States

Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac, Michigan, United States

Lake Huron Medical Center, Port Huron, Michigan, United States

Ascension Saint Mary's Hospital, Saginaw, Michigan, United States

Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph, Michigan, United States

Corewell Health Lakeland Hospitals - Saint Joseph Hospital, Saint Joseph, Michigan, United States

Ascension Providence Hospitals - Southfield, Southfield, Michigan, United States

Munson Medical Center, Traverse City, Michigan, United States

Saint John Macomb-Oakland Hospital, Warren, Michigan, United States

University of Michigan Health - West, Wyoming, Michigan, United States

Medini, Eitan MD (UIA Investigator), Alexandria, Minnesota, United States

Essentia Health Cancer Center, Duluth, Minnesota, United States

Essentia Health Saint Mary's Medical Center, Duluth, Minnesota, United States

Miller-Dwan Hospital, Duluth, Minnesota, United States

Etzell, Paul S MD (UIA Investigator), Fergus Falls, Minnesota, United States

Swenson, Wade II, MD (UIA Investigator), Fergus Falls, Minnesota, United States

Mayo Clinic Health Systems-Mankato, Mankato, Minnesota, United States

Coborn Cancer Center at Saint Cloud Hospital, Saint Cloud, Minnesota, United States

Saint Cloud Hospital, Saint Cloud, Minnesota, United States

Rice Memorial Hospital, Willmar, Minnesota, United States

University of Mississippi Medical Center, Jackson, Mississippi, United States

Singing River Hospital, Pascagoula, Mississippi, United States

Central Care Cancer Center - Bolivar, Bolivar, Missouri, United States

Cox Cancer Center Branson, Branson, Missouri, United States

Southeast Missouri Hospital, Cape Girardeau, Missouri, United States

Saint Francis Medical Center, Cape Girardeau, Missouri, United States

Southeast Cancer Center, Cape Girardeau, Missouri, United States

MU Health - University Hospital/Ellis Fischel Cancer Center, Columbia, Missouri, United States

MU Health Care Goldschmidt Cancer Center, Jefferson City, Missouri, United States

Freeman Health System, Joplin, Missouri, United States

University Health Truman Medical Center, Kansas City, Missouri, United States

Delbert Day Cancer Institute at PCRMC, Rolla, Missouri, United States

Saint Louis Cancer and Breast Institute-South City, Saint Louis, Missouri, United States

Washington University School of Medicine, Saint Louis, Missouri, United States

Missouri Baptist Medical Center, Saint Louis, Missouri, United States

Comprehensive Cancer Care PC, Saint Louis, Missouri, United States

Mercy Hospital Saint Louis, Saint Louis, Missouri, United States

Saint Louis-Cape Girardeau CCOP, Saint Louis, Missouri, United States

Cancer Research for the Ozarks NCORP, Springfield, Missouri, United States

Mercy Hospital Springfield, Springfield, Missouri, United States

CoxHealth South Hospital, Springfield, Missouri, United States

Billings Clinic Cancer Center, Billings, Montana, United States

Northern Rockies Radiation Oncology Center, Billings, Montana, United States

Saint Vincent Healthcare, Billings, Montana, United States

Montana Cancer Consortium NCORP, Billings, Montana, United States

Saint Vincent Frontier Cancer Center, Billings, Montana, United States

Bozeman Health Deaconess Hospital, Bozeman, Montana, United States

Saint James Community Hospital and Cancer Treatment Center, Butte, Montana, United States

Benefis Sletten Cancer Institute, Great Falls, Montana, United States

Berdeaux, Donald MD (UIA Investigator), Great Falls, Montana, United States

Great Falls Clinic, Great Falls, Montana, United States

Northern Montana Hospital, Havre, Montana, United States

Saint Peter's Community Hospital, Helena, Montana, United States

Glacier Oncology PLLC, Kalispell, Montana, United States

Kalispell Medical Oncology, Kalispell, Montana, United States

Kalispell Regional Medical Center, Kalispell, Montana, United States

Montana Cancer Specialists, Missoula, Montana, United States

Saint Patrick Hospital - Community Hospital, Missoula, Montana, United States

Community Medical Center, Missoula, Montana, United States

Guardian Oncology and Center for Wellness, Missoula, Montana, United States

Nebraska Cancer Specialists/Oncology Hematology West PC, Grand Island, Nebraska, United States

Nebraska Cancer Research Center, Lincoln, Nebraska, United States

Great Plains Health Callahan Cancer Center, North Platte, Nebraska, United States

Missouri Valley Cancer Consortium, Omaha, Nebraska, United States

Alegent Health Immanuel Medical Center, Omaha, Nebraska, United States

Alegent Health Bergan Mercy Medical Center, Omaha, Nebraska, United States

Creighton University Medical Center, Omaha, Nebraska, United States

University of Nebraska Medical Center, Omaha, Nebraska, United States

Renown Regional Medical Center, Reno, Nevada, United States

New Hampshire Oncology Hematology PA-Concord, Concord, New Hampshire, United States

Cheshire Medical Center-Dartmouth-Hitchcock Keene, Keene, New Hampshire, United States

LRGHealthcare-Lakes Region General Hospital, Laconia, New Hampshire, United States

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire, United States

Solinsky Center for Cancer Care, Manchester, New Hampshire, United States

Saint Joseph Hospital, Nashua, New Hampshire, United States

Cooper Hospital University Medical Center, Camden, New Jersey, United States

CentraState Medical Center, Freehold, New Jersey, United States

Hackensack University Medical Center, Hackensack, New Jersey, United States

Morristown Medical Center, Morristown, New Jersey, United States

Newark Beth Israel Medical Center, Newark, New Jersey, United States

Overlook Hospital, Summit, New Jersey, United States

Inspira Medical Center Vineland, Vineland, New Jersey, United States

Montefiore Medical Center-Weiler Hospital, Bronx, New York, United States

Montefiore Medical Center-Wakefield Campus, Bronx, New York, United States

Montefiore Medical Center - Moses Campus, Bronx, New York, United States

Hematology Oncology Associates of Central New York-East Syracuse, East Syracuse, New York, United States

Elmhurst Hospital Center, Elmhurst, New York, United States

Arnot Ogden Medical Center/Falck Cancer Center, Elmira, New York, United States

Adirondack Cancer Center, Glens Falls, New York, United States

Queens Hospital Center, Jamaica, New York, United States

Mount Sinai Union Square, New York, New York, United States

Mount Sinai West, New York, New York, United States

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York, New York, United States

Ralph Lauren Center for Cancer Care and Prevention, New York, New York, United States

Memorial Sloan Kettering Cancer Center, New York, New York, United States

NYP/Weill Cornell Medical Center, New York, New York, United States

Highland Hospital, Rochester, New York, United States

Interlakes Foundation Inc-Rochester, Rochester, New York, United States

University of Rochester, Rochester, New York, United States

Staten Island University Hospital, Staten Island, New York, United States

Faxton-Saint Luke's Healthcare, Utica, New York, United States

Randolph Hospital, Asheboro, North Carolina, United States

UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina, United States

Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina, United States

Wayne Memorial Hospital, Goldsboro, North Carolina, United States

Cone Health Cancer Center, Greensboro, North Carolina, United States

ECU Health Oncology Kinston, Kinston, North Carolina, United States

Annie Penn Memorial Hospital, Reidsville, North Carolina, United States

Rutherford Hospital, Rutherfordton, North Carolina, United States

Southeast Clinical Oncology Research Consortium NCORP, Winston-Salem, North Carolina, United States

Wake Forest University Health Sciences, Winston-Salem, North Carolina, United States

Mid Dakota Clinic, Bismarck, North Dakota, United States

Saint Alexius Medical Center, Bismarck, North Dakota, United States

Sanford Bismarck Medical Center, Bismarck, North Dakota, United States

Altru Cancer Center, Grand Forks, North Dakota, United States

Trinity Cancer Care Center, Minot, North Dakota, United States

Mary Rutan Hospital, Bellefontaine, Ohio, United States

Aultman Health Foundation, Canton, Ohio, United States

Adena Regional Medical Center, Chillicothe, Ohio, United States

MetroHealth Medical Center, Cleveland, Ohio, United States

Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States

Riverside Methodist Hospital, Columbus, Ohio, United States

Columbus NCI Community Oncology Research Program, Columbus, Ohio, United States

Grant Medical Center, Columbus, Ohio, United States

Mount Carmel Health Center West, Columbus, Ohio, United States

Doctors Hospital, Columbus, Ohio, United States

Grandview Hospital, Dayton, Ohio, United States

Good Samaritan Hospital - Dayton, Dayton, Ohio, United States

Miami Valley Hospital, Dayton, Ohio, United States

Miami Valley Hospital North, Dayton, Ohio, United States

Dayton Veterans Affairs Medical Center, Dayton, Ohio, United States

Grady Memorial Hospital, Delaware, Ohio, United States

Blanchard Valley Hospital, Findlay, Ohio, United States

Atrium Medical Center-Middletown Regional Hospital, Franklin, Ohio, United States

Wayne Hospital, Greenville, Ohio, United States

Kettering Medical Center, Kettering, Ohio, United States

Fairfield Medical Center, Lancaster, Ohio, United States

Saint Rita's Medical Center, Lima, Ohio, United States

Marietta Memorial Hospital, Marietta, Ohio, United States

Knox Community Hospital, Mount Vernon, Ohio, United States

Licking Memorial Hospital, Newark, Ohio, United States

Southern Ohio Medical Center, Portsmouth, Ohio, United States

Springfield Regional Medical Center, Springfield, Ohio, United States

Upper Valley Medical Center, Troy, Ohio, United States

Saint Ann's Hospital, Westerville, Ohio, United States

Clinton Memorial Hospital/Foster J Boyd Regional Cancer Center, Wilmington, Ohio, United States

Greene Memorial Hospital, Xenia, Ohio, United States

Genesis Healthcare System Cancer Care Center, Zanesville, Ohio, United States

Natalie Warren Bryant Cancer Center at Saint Francis, Tulsa, Oklahoma, United States

Saint Charles Health System, Bend, Oregon, United States

Clackamas Radiation Oncology Center, Clackamas, Oregon, United States

Legacy Mount Hood Medical Center, Gresham, Oregon, United States

Providence Milwaukie Hospital, Milwaukie, Oregon, United States

Providence Newberg Medical Center, Newberg, Oregon, United States

Providence Willamette Falls Medical Center, Oregon City, Oregon, United States

Legacy Good Samaritan Hospital and Medical Center, Portland, Oregon, United States

Providence Portland Medical Center, Portland, Oregon, United States

Adventist Medical Center, Portland, Oregon, United States

Providence Saint Vincent Medical Center, Portland, Oregon, United States

Kaiser Permanente Northwest, Portland, Oregon, United States

Legacy Emanuel Hospital and Health Center, Portland, Oregon, United States

Legacy Meridian Park Hospital, Tualatin, Oregon, United States

Jefferson Abington Hospital, Abington, Pennsylvania, United States

Lehigh Valley Hospital-Cedar Crest, Allentown, Pennsylvania, United States

Bryn Mawr Hospital, Bryn Mawr, Pennsylvania, United States

Doylestown Hospital, Doylestown, Pennsylvania, United States

Paoli Memorial Hospital, Paoli, Pennsylvania, United States

West Penn Hospital, Pittsburgh, Pennsylvania, United States

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh, Pennsylvania, United States

Guthrie Medical Group PC-Robert Packer Hospital, Sayre, Pennsylvania, United States

Mercy Hospital, Scranton, Pennsylvania, United States

Scranton Hematology Oncology, Scranton, Pennsylvania, United States

Grand View Hospital, Sellersville, Pennsylvania, United States

Chester County Hospital, West Chester, Pennsylvania, United States

Reading Hospital, West Reading, Pennsylvania, United States

UPMC Susquehanna, Williamsport, Pennsylvania, United States

Lankenau Medical Center, Wynnewood, Pennsylvania, United States

Hematology and Oncology Associates of Rhode Island Inc, Cranston, Rhode Island, United States

Memorial Hospital of Rhode Island, Pawtucket, Rhode Island, United States

Kent Hospital, Warwick, Rhode Island, United States

AnMed Health Cancer Center, Anderson, South Carolina, United States

AnMed Health Hospital, Anderson, South Carolina, United States

McLeod Regional Medical Center, Florence, South Carolina, United States

Saint Francis Hospital, Greenville, South Carolina, United States

Spartanburg Medical Center, Spartanburg, South Carolina, United States

Avera Cancer Institute-Aberdeen, Aberdeen, South Dakota, United States

Rapid City Regional Hospital, Rapid City, South Dakota, United States

Sanford Cancer Center Oncology Clinic, Sioux Falls, South Dakota, United States

Avera Cancer Institute, Sioux Falls, South Dakota, United States

Medical X-Ray Center, Sioux Falls, South Dakota, United States

Avera McKennan Hospital and University Health Center, Sioux Falls, South Dakota, United States

Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota, United States

Erlanger Medical Center, Chattanooga, Tennessee, United States

Doctor's Hospital of Laredo, Laredo, Texas, United States

Sentara Martha Jefferson Hospital, Charlottesville, Virginia, United States

Danville Regional Medical Center, Danville, Virginia, United States

Kaiser Permanente - Fair Oaks Medical Center, Fairfax, Virginia, United States

Providence Regional Cancer System-Centralia, Centralia, Washington, United States

Saint Francis Hospital, Federal Way, Washington, United States

Saint Clare Hospital, Lakewood, Washington, United States

Providence - Saint Peter Hospital, Olympia, Washington, United States

MultiCare Good Samaritan Hospital, Puyallup, Washington, United States

Providence Sacred Heart Medical Center and Children's Hospital, Spokane, Washington, United States

Providence Holy Family Hospital, Spokane, Washington, United States

Rockwood Clinic, Spokane, Washington, United States

MultiCare Allenmore Hospital, Tacoma, Washington, United States

Saint Joseph Medical Center, Tacoma, Washington, United States

PeaceHealth Southwest Medical Center, Vancouver, Washington, United States

West Virginia University Charleston Division, Charleston, West Virginia, United States

Wheeling Hospital/Schiffler Cancer Center, Wheeling, West Virginia, United States

Langlade Hospital and Cancer Center, Antigo, Wisconsin, United States

Aurora Cancer Care-Southern Lakes VLCC, Burlington, Wisconsin, United States

Marshfield Clinic-Chippewa Center, Chippewa Falls, Wisconsin, United States

Marshfield Clinic Cancer Center at Sacred Heart, Eau Claire, Wisconsin, United States

Aurora Cancer Care-Franklin, Franklin, Wisconsin, United States

Aurora Health Care Germantown Health Center, Germantown, Wisconsin, United States

Aurora Cancer Care-Glendale, Glendale, Wisconsin, United States

Green Bay Oncology at Saint Vincent Hospital, Green Bay, Wisconsin, United States

Bellin Memorial Hospital, Green Bay, Wisconsin, United States

Saint Vincent Hospital Cancer Center Green Bay, Green Bay, Wisconsin, United States

Green Bay Oncology Limited at Saint Mary's Hospital, Green Bay, Wisconsin, United States

Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay, Wisconsin, United States

Aurora BayCare Medical Center, Green Bay, Wisconsin, United States

Mercyhealth Hospital and Cancer Center - Janesville, Janesville, Wisconsin, United States

Aurora Cancer Care-Kenosha South, Kenosha, Wisconsin, United States

Gundersen Lutheran Medical Center, La Crosse, Wisconsin, United States

SSM Health Dean Medical Group - South Madison Campus, Madison, Wisconsin, United States

Holy Family Memorial Hospital, Manitowoc, Wisconsin, United States

Aurora Bay Area Medical Group-Marinette, Marinette, Wisconsin, United States

Bay Area Medical Center, Marinette, Wisconsin, United States

Marshfield Medical Center-Marshfield, Marshfield, Wisconsin, United States

Marshfield Medical Center, Marshfield, Wisconsin, United States

Aurora Saint Luke's Medical Center, Milwaukee, Wisconsin, United States

Medical College of Wisconsin, Milwaukee, Wisconsin, United States

Aurora Sinai Medical Center, Milwaukee, Wisconsin, United States

Marshfield Clinic-Minocqua Center, Minocqua, Wisconsin, United States

ProHealth Oconomowoc Memorial Hospital, Oconomowoc, Wisconsin, United States

Saint Vincent Hospital Cancer Center at Oconto Falls, Oconto Falls, Wisconsin, United States

Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh, Wisconsin, United States

Aurora Cancer Care-Racine, Racine, Wisconsin, United States

Ascension Saint Mary's Hospital, Rhinelander, Wisconsin, United States

Marshfield Medical Center-Rice Lake, Rice Lake, Wisconsin, United States

HSHS Saint Nicholas Hospital, Sheboygan, Wisconsin, United States

Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan, Wisconsin, United States

Ascension Saint Michael's Hospital, Stevens Point, Wisconsin, United States

Green Bay Oncology - Sturgeon Bay, Sturgeon Bay, Wisconsin, United States

Aurora Medical Center in Summit, Summit, Wisconsin, United States

Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers, Wisconsin, United States

Aurora Cancer Care-Waukesha, Waukesha, Wisconsin, United States

ProHealth Waukesha Memorial Hospital, Waukesha, Wisconsin, United States

Aspirus Regional Cancer Center, Wausau, Wisconsin, United States

Aurora Cancer Care-Milwaukee West, Wauwatosa, Wisconsin, United States

Aurora West Allis Medical Center, West Allis, Wisconsin, United States

Marshfield Medical Center - Weston, Weston, Wisconsin, United States

Aspirus Cancer Care - Wisconsin Rapids, Wisconsin Rapids, Wisconsin, United States

Marshfield Clinic - Wisconsin Rapids Center, Wisconsin Rapids, Wisconsin, United States

Rocky Mountain Oncology, Casper, Wyoming, United States

Welch Cancer Center, Sheridan, Wyoming, United States

San Juan City Hospital, San Juan, , Puerto Rico

Contact Details

Name: Hope S Rugo

Affiliation: Alliance for Clinical Trials in Oncology

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

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