Spots Global Cancer Trial Database for Single Fraction Intraoperative Radiotherapy

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Trial Identification

Brief Title: Single Fraction Intraoperative Radiotherapy

Official Title: Single Fraction Intraoperative Radiotherapy With Electrons: An Option in Breast-Conserving Operable Breast Cancer Stages 0, I and II - Prospective, Single-arm Trial

Study ID: NCT01688388

Conditions

Invasive Ductal and Invasive Lobular Breast Carcinoma

Stage 0 Breast Carcinoma

Stage I Breast Carcinoma

Stage II Breast Carcinoma

Interventions

Intraoperative Radiotherapy

Study Description

Brief Summary: This clinical trial is being conducted to find out the effects (good and bad) of giving the full radiation treatment for breast cancer as a single dose of radiation during surgery for breast cancer. This single fraction intraoperative radiotherapy with electrons will study the toxicity, local control and cosmetic outcome.

Detailed Description: For patients with certain types of breast cancer, one standard treatment is breast conserving surgery or lumpectomy (surgery to remove abnormal tissue or cancer from the breast and a small amount of normal tissue around it) followed by breast radiation. The radiation treatment in this situation usually lasts 3 to 5 1/2 weeks followed by 5-8 daily localized irradiation (or boost) treatments at the site where the lump was removed. During this study, the single dose of electron irradiation given at the surgical site during the operation will replace the radiation given after surgery.