Spots Global Cancer Trial Database for Studying Biomarkers in Samples From Young Patients With Rhabdoid Tumors
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Trial Identification
Brief Title: Studying Biomarkers in Samples From Young Patients With Rhabdoid Tumors
Official Title: Endogenous DNA Transposition in Rhabdoid Tumors
Study ID: NCT01544569
Conditions
Study Description
Brief Summary: RATIONALE: Studying samples of tissue from patients with rhabdoid tumors in the laboratory may help doctor learn more about changes that occur in DNA and identify genes related to cancer. PURPOSE: This research trial studies biomarkers in samples from young patients with rhabdoid tumors.
Detailed Description: OBJECTIVES: * To investigate the expression and function of transposons in 50 primary rhabdoid tumors. OUTLINE: Freshly frozen rhabdoid tumors will be studied using fluorescence in situ hybridization (FISH) and polymerase chain reaction (PCR) to establish the genomic location of transposons. Protein expression in rhabdoid tumor tissue microarrays is also analyzed.
Keywords
Eligibility
Minimum Age:
Eligible Ages: CHILD
Sex: ALL
Healthy Volunteers: No
Locations
Contact Details
Name: Elizabeth A. Mullen, MD
Affiliation: Dana-Farber Cancer Institute
Role: PRINCIPAL_INVESTIGATOR
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