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Spots Global Cancer Trial Database for Reduction of Allogenic Blood Transfusion in Locally Advanced Kidney Cancer

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Trial Identification

Brief Title: Reduction of Allogenic Blood Transfusion in Locally Advanced Kidney Cancer

Official Title: Reduction of Allogenic Blood Transfusion in Locally Advanced Kidney Cancer

Study ID: NCT04922307

Conditions

Kidney Cancer

Study Description

Brief Summary: The Reduction of Allogenic Blood Transfusion in Locally Advanced Kidney Cancer Trial (RESTRICT). The primary objective is to reduce the number of units of allogenic blood transfusion in locally advanced kidney cancer (≥ cT2). Secondary objectives include reduction in perioperative complications, assessment of recurrence free-survival and improving overall survival.

Detailed Description: The Reduction of Allogenic Blood Transfusion in Locally Advanced Kidney Cancer Trial (RESTRICT) is a randomized study to investigate blood sparing using autologous normovolemic hemodilution (ANH) or cell salvage at the time of nephrectomy for locally advanced kidney cancer after assessing inclusion criteria patients will be randomized to undergo standard blood management including the possibility of allogenic transfusion vs autologous blood transfusion. There are multiple ways patients can receive allogenic or autologous blood, including veno-venous bypass or cardiopulmonary bypass (typically reserved for patients with a thrombus above the level of the hepatic veins or entering the heart).

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

H. Lee Moffitt Cancer Center, Tampa, Florida, United States

Winship Cancer Institute at Emory University, Atlanta, Georgia, United States

Vanderbilt University Medical Center, Nashville, Tennessee, United States

Contact Details

Name: Kelvin Moses

Affiliation: Associate Professor

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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