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Brief Title: Reduction of Allogenic Blood Transfusion in Locally Advanced Kidney Cancer
Official Title: Reduction of Allogenic Blood Transfusion in Locally Advanced Kidney Cancer
Study ID: NCT04922307
Brief Summary: The Reduction of Allogenic Blood Transfusion in Locally Advanced Kidney Cancer Trial (RESTRICT). The primary objective is to reduce the number of units of allogenic blood transfusion in locally advanced kidney cancer (≥ cT2). Secondary objectives include reduction in perioperative complications, assessment of recurrence free-survival and improving overall survival.
Detailed Description: The Reduction of Allogenic Blood Transfusion in Locally Advanced Kidney Cancer Trial (RESTRICT) is a randomized study to investigate blood sparing using autologous normovolemic hemodilution (ANH) or cell salvage at the time of nephrectomy for locally advanced kidney cancer after assessing inclusion criteria patients will be randomized to undergo standard blood management including the possibility of allogenic transfusion vs autologous blood transfusion. There are multiple ways patients can receive allogenic or autologous blood, including veno-venous bypass or cardiopulmonary bypass (typically reserved for patients with a thrombus above the level of the hepatic veins or entering the heart).
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
H. Lee Moffitt Cancer Center, Tampa, Florida, United States
Winship Cancer Institute at Emory University, Atlanta, Georgia, United States
Vanderbilt University Medical Center, Nashville, Tennessee, United States
Name: Kelvin Moses
Affiliation: Associate Professor
Role: PRINCIPAL_INVESTIGATOR