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Brief Title: Axitinib (AG 013736) As Second Line Therapy For Metastatic Renal Cell Cancer
Official Title: AXITINIB (AG-013736) AS SECOND LINE THERAPY FOR METASTATIC RENAL CELL CANCER: AXIS TRIAL
Study ID: NCT00678392
Brief Summary: The study is designed to demonstrate that axitinib (AG-013736) is superior to sorafenib in delaying tumor progression in patients with metastatic renal cell cancer after failure of one first line regimen.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
East Valley Hematology and Oncology Medical Group, Burbank, California, United States
Maurice Berkowtiz, MD, Burbank, California, United States
Agajanian Institute of Oncology and Hematology, Downey, California, United States
Los Angeles Hematology/Oncology Medical Group, Glendale, California, United States
Los Angeles Hematology/Oncology Medical Group, Los Angeles, California, United States
LAC-USC Medical Center, Los Angeles, California, United States
USC Norris Cancer Hospital and Clinics, Los Angeles, California, United States
Kenmar Research Institute, Los Angeles, California, United States
Metropolitan Hematology/Oncology Medical Group, Los Angeles, California, United States
Ronald Regan UCLA Medical Center, Los Angeles, California, United States
UCLA, Los Angeles, California, United States
Agajanian Institute of Oncology and Hematology, Montebello, California, United States
Brian LeBerthon, MD, A Medical Corporation, West Covina, California, United States
Agajanian Institute of Oncology and Hematology, Whittier, California, United States
Rocky Mountain Cancer Centers, Aurora, Colorado, United States
University of Colorado Cancer Center, Aurora, Colorado, United States
University of Colorado Denver: Division of Medical Oncology, Aurora, Colorado, United States
Rocky Mountain Cancer Centers, Boulder, Colorado, United States
Rocky Mountain Cancer Centers, Colorado Springs, Colorado, United States
Rocky Mountain Cancer Centers, LLP, Denver, Colorado, United States
Rocky Mountain Cancer Centers, Denver, Colorado, United States
Rocky Mountain Cancer Centers, Lakewood, Colorado, United States
Rocky Mountain Cancer Centers, Littleton, Colorado, United States
Rocky Mountain Cancer Centers, Lone Tree, Colorado, United States
Rocky Mountain Cancer Centers, Longmont, Colorado, United States
Rocky Mountain Cancer Centers, Parker, Colorado, United States
Rocky Mountain Cancer Centers, Thornton, Colorado, United States
Georgetown University Hospital, Lombardi Cancer Center, Washington, District of Columbia, United States
Georgetown University Medical Center, Washington, District of Columbia, United States
Florida Cancer Specialists, Bonita Springs, Florida, United States
Florida Cancer Specialists, Bradenton, Florida, United States
Florida Cancer Specialists, Cape Coral, Florida, United States
Florida Cancer Specialists, Cape Coral, Florida, United States
University of Miami Sylvester at Deerfield Beach, Deerfield Beach, Florida, United States
Florida Cancer Specialists, Englewood, Florida, United States
Florida Cancer Specialists, Fort Myers, Florida, United States
Florida Cancer Specialists, Fort Myers, Florida, United States
Florida Cancer Specialists, Fort Myers, Florida, United States
Florida Cancer Specialists, Fort Myers, Florida, United States
University of Miami Hospital and Clinics, Miami, Florida, United States
Florida Cancer Specialists, Naples, Florida, United States
Florida Cancer Specialists, Naples, Florida, United States
M.D. Anderson Cancer Center Orlando, Orlando, Florida, United States
Orlando Regional Medical Center, Orlando, Florida, United States
Florida Cancer Specialists, Port Charlotte, Florida, United States
Florida Cancer Specialists, Sarasota, Florida, United States
Florida Cancer Specialists, Sarasota, Florida, United States
Florida Cancer Specialists, Venice, Florida, United States
Florida Cancer Specialists, Venice, Florida, United States
Peachtree Hematology-Oncology Consultants, P.C., Atlanta, Georgia, United States
Chattanooga Oncology and Hematology Associates, PC, Ringgold, Georgia, United States
Mountain States Tumor Institute, Boise, Idaho, United States
Mountain States Tumor Institute, Fruitland, Idaho, United States
Mountain States Tumor Institute, Meridian, Idaho, United States
Mountain States Tumor Institute, Nampa, Idaho, United States
Mountain States Tumor Institute, Twin Falls, Idaho, United States
Loyola University Chicago Cardinal Bernardin Cancer Center, Maywood, Illinois, United States
Cental Indiana Cancer Centers, Carmel, Indiana, United States
Central Indiana Cancer Centers, Fishers, Indiana, United States
Cental Indiana Cancer Centers, Greenfield, Indiana, United States
Central Indiana Cancer Centers, Indianapolis, Indiana, United States
Central Indiana Cancer Centers, Indianapolis, Indiana, United States
Massachusetts General Hospital, Boston, Massachusetts, United States
Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
University of Michigan Health System, Ann Arbor, Michigan, United States
Karmanos Cancer Institute, Detroit, Michigan, United States
Weisberg Cancer Treatment Center, Farmington Hills, Michigan, United States
University of Minnesota Medical Center Fairview, Minneapolis, Minnesota, United States
Missouri Cancer Associates, Columbia, Missouri, United States
St. John's Mercy Medical Center, Saint Louis, Missouri, United States
St. John's Mercy, David C. Pratt Cancer Center, Saint Louis, Missouri, United States
St. John's Mercy Medical Center, Washington, Missouri, United States
Comprehensive Cancer Centers of Nevada, Henderson, Nevada, United States
Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada, United States
Nevada Cancer Institute, Las Vegas, Nevada, United States
Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada, United States
Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada, United States
Hackensack University Medical Center, Hackensack, New Jersey, United States
The Cancer Center at Hackensack University Medical Center - The Hillcrest Building, Hackensack, New Jersey, United States
The Cancer Center at Hackensack University Medical Center, Hackensack, New Jersey, United States
Montefiore Medical Center, Bronx, New York, United States
Memorial Sloan Kettering Cancer Center - Sidney Kimmel Center, New York, New York, United States
Memorial Sloan Kettering Cancer Center, New York, New York, United States
Department of Medicine MSG @ SUNY HSC @ Syrcacuse, Inc., Oneida, New York, United States
Department of Medicine MSG @ SUNY HSC @ Syracuse, Inc., Oswego, New York, United States
Suny Upstate Medical University, Syracuse, New York, United States
Department of Medicine MSG @ SUNY HSC @ Syracuse, Inc, Syracuse, New York, United States
Raleigh Hematology Oncology Associates, DBA, Cary, North Carolina, United States
Duke University Medical Center, Durham, North Carolina, United States
Investigational Chemotherapy Services, Durham, North Carolina, United States
Albermarie Hospitals, Elizabeth City, North Carolina, United States
Virginia Oncology Associates, Elizabeth City, North Carolina, United States
Raleigh Hematology Oncology Associates, P.C., Raleigh, North Carolina, United States
Case Western Reserve University, Cleveland, Ohio, United States
Cleveland Clinic Foundation, Cleveland, Ohio, United States
Ohio State University Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, Ohio, United States
Ohio State University, Columbus, Ohio, United States
James Care in Kenny, Columbus, Ohio, United States
Monarch, Mayfield Heights, Ohio, United States
Lake University - Ireland Cancer Center (LUICC), Mentor, Ohio, United States
UHHS - Chagrin Highlands, Orange Village, Ohio, United States
UHHS - Westlake, Westlake, Ohio, United States
Oncology Associates of Oregon, P.C., Eugene, Oregon, United States
Willamette Valley Cancer Institute and Research Center, Springfield, Oregon, United States
Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States
Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States
Medical University of South Carolina, Charleston, South Carolina, United States
Cancer Centers of the Carolinas, Easley, South Carolina, United States
Cancer Centers of the Carolinas, Greenville, South Carolina, United States
Hematology and Oncology Associates of SC, LLC - Eastside Medical Center, Greenville, South Carolina, United States
Cancer Centers of the Carolinas, Seneca, Seneca, South Carolina, United States
Cancer Centers of the Carolinas, Spartanburg, South Carolina, United States
Chattanooga Oncology and Hematology Associates, PC, Chattanooga, Tennessee, United States
Chattanooga Oncology Hematology Associates P.C., Chattanooga, Tennessee, United States
Tennessee Oncology, PLLC, Franklin, Tennessee, United States
Vanderbilt-Ingram Cancer Center-Cool Springs, Franklin, Tennessee, United States
Tennessee Oncology, PLLC, Gallatin, Tennessee, United States
Tennessee Oncology, PLLC, Hermitage, Tennessee, United States
Chattanooga Oncology & Hematology Associates, Hixson, Tennessee, United States
Tennessee Oncology, PLLC, Lebanon, Tennessee, United States
Tennessee Oncology, PLLC, Murfreesboro, Tennessee, United States
Sarah Cannon Research Institute, Nashville, Tennessee, United States
Tennessee Oncology, PLLC, Nashville, Tennessee, United States
Tennessee Oncology, PLLC, Nashville, Tennessee, United States
Tennessee Oncology, PLLC, Nashville, Tennessee, United States
Tennessee Oncology, PLLC, Nashville, Tennessee, United States
Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, United States
Vanderbilt University Medical Center, Nashville, Tennessee, United States
Tennessee Oncology, PLLC, Smyrna, Tennessee, United States
Texas Oncology - Austin Midtown, Austin, Texas, United States
Texas Oncology - Central Midtown, Austin, Texas, United States
Texas Oncology - Austin Central, Austin, Texas, United States
Texas Oncology - South Austin, Austin, Texas, United States
Texas Oncolgoy - Austin North, Austin, Texas, United States
Texas Oncology - Austin Northwest, Austin, Texas, United States
Texas Oncology, P.A., Bedford, Texas, United States
Texas Oncology - Cedar Park, Cedar Park, Texas, United States
Texas Oncology - Baylor Charles A. Sammons Cancer Center, Dallas, Texas, United States
Investigation Products Center (IPC), Fort Worth, Texas, United States
Investigational Products Center (IPC), Fort Worth, Texas, United States
US Oncology Research and Clinical Pharmacy, Fort Worth, Texas, United States
Genitourinary Cancer Center, Houston, Texas, United States
The University of Texas MD Anderson Cancer Center, Houston, Texas, United States
Texas Oncology - Seton Williamson, Round Rock, Texas, United States
Texas Oncology - Round Rock, Round Rock, Texas, United States
Texas Oncology, P.A., Tyler, Texas, United States
Deke Slayton Cancer Center, Webster, Texas, United States
Texas Oncology - Clear Lake, Webster, Texas, United States
Virginia Cancer Specialists, PC, Arlington, Virginia, United States
Virginia Oncology Associates, Chesapeake, Virginia, United States
Virginia Cancer Specialists, PC, Fairfax, Virginia, United States
Virginia Cancer Specialists, PC, Gainesville, Virginia, United States
Virginia Oncology Associates, Hampton, Virginia, United States
Virginia Cancer Specialists, PC, Leesburg, Virginia, United States
Virginia Oncology Associates, Newport News, Virginia, United States
Virginia Oncology Associates, Norfolk, Virginia, United States
Virginia Oncology Associates, Virginia Beach, Virginia, United States
Virginia Cancer Specialists, PC, Woodbridge, Virginia, United States
Virginia Mason Medical Center, Section of Hematology/Oncology, Seattle, Washington, United States
Seattle Cancer Care Alliance, Seattle, Washington, United States
University of Washington Medical Center, Seattle, Washington, United States
The Canberra Hospital, Medical Oncology, Garran, Australian Capital Territory, Australia
Ashford Cancer Centre Research, Kurralta Park, South Australia, Australia
Ballarat Oncology & Haematology Services, Ballarat, Victoria, Australia
Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Heidelberg Repatriation Hospital, Austin Health, Heidelberg West, Victoria, Australia
Austin Hospital, Austin Health, Heidelberg, Victoria, Australia
Med. Abt. KH Barmherzige Brueder Wien, Krankenhaus der Barmherzigen Brueder Wien, Wien, , Austria
Universitaets-Klinik fuer Innere Medizin I, Wien, , Austria
Clinica Oncologistas Associados, Rio de Janeiro, RJ, Brazil
Irmandade da Santa Casa de Misericordia de Porto Alegre (ISCMPA) - Hospital Santa Rita, Porto Alegre, RS, Brazil
Fundacao Pio XII Hospital de Cancer de Barretos, Barretos, SP, Brazil
Fundacao Antonio Prudente, Sao Paulo, SP, Brazil
Tom Baker Cancer Centre, Calgary, Alberta, Canada
Cross Cancer Institute, Edmonton, Alberta, Canada
British Columbia Cancer Agency - Cancer Centre for the Southern Interior, Kelowna, British Columbia, Canada
Dr. Leon Richard Oncology Centre, Moncton, New Brunswick, Canada
Dr. H. Bliss Murphy Cancer Centre, St. John's, Newfoundland and Labrador, Canada
RSM Durham Regional Cancer Centre Lakeridge Health Oshawa, Oshawa, Ontario, Canada
Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, Chaoyang District, China
The Department of Medical Oncology, PLA Cancer Center, Nanjing Bayi Hospital, Nanjing, Jiangsu, China
Beijing Cancer Hospital, Beijing, P.R., China
Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, China
Sun Yet-Sen University Cancer Center, Guangzhou, , China
Urology Department, Renji Hospital,Shanghai Jiao Tong University School of Medicine, Shanghai, , China
Tianjin Oncology Hospital,biology treatment department, Tianjin, , China
Centre Leon Berard, Lyon, Cedex 08, France
Hopital Saint-André, Bordeaux Cedex, , France
Hôpital Henri Mondor, CRETEIL Cedex, , France
Institut Paoli-Calmettes, Marseille Cedex 09, , France
Hopital Europeen Georges Pompidou, Paris Cedex 15, , France
Centre Eugene Marquis, Rennes, , France
Centre Rene Gauducheau - Service Oncologie Medicale, St Herblain Cedex, , France
CHRU de Tours - Hopital Bretonneau, Tours Cedex 1, , France
Centre Alexis Vautrin, Vandoeuvre les Nancy, , France
Institut Gustave Roussy / Service d'Immunotherapie, Villejuif Cedex, , France
RWTH Aachen, Urologische Klinik, Aachen, , Germany
Charite - Universitaetsmedizin Berlin, Campus Benjamin Franklin, Berlin, , Germany
Innere Klinik und Poliklinik fuer Tumorforschung, Universitaetsklinikum Essen, Essen, , Germany
Klinikum Region Hannover Krankenhaus Siloah, Hannover, , Germany
Klinikum der Johannes-Gutenberg-Universitaet, III. Medizinische Klinik und Poliklinik, Mainz, , Germany
Ludwig-Maximilians-Universitaet Muenchen, Klinikum Grosshadern Urologische Klinik und Poliklinik, Muenchen, , Germany
Klinikum Oldenburg gGmbH, Klinik fuer Innere Medizin II Onkologie / Haematologie, Oldenburg, , Germany
Alexandra University Hospital / Oncology Dept., Athens, Attiki, Greece
"Theagenio"Cancer Hospital / 3rd. Dept. of Clinical Oncology, Thessaloniki, Macedonia, Greece
Fortis Memorial Research Institute, Gurgaon, Haryana, India
Amrita Institute of Medical Sciences, Kochi, Kerala, India
Dept. of Medical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India
Christian Medical College & Hospital, Ludhiana, Punjab, India
Bhagwan Mahaveer Cancer Hospital and Research Center, Jaipur, Rajasthan, India
Oncology Department, Dublin 24, , Ireland
UOC Oncologia Medica, Ospedale San Donato, Arezzo, , Italy
Centro di Riferimento Oncologico, Istituto Nazionale Tumori, IRCCS, Aviano (PN), , Italy
Dipartimento dei laboratori diagnositici e per le terapie cellulari, Aviano (PN), , Italy
Azienda Ospedaliera Spedali Civili di Brescia, Unita' Operativa Oncologia Medica, Brescia, , Italy
Struttura Complessa di Oncologia, Cremona, , Italy
UOC Oncologia Medica B, IRCCS AO Universitaria San Martino, Genova, , Italy
Fondazione IRCCS, Istituto Nazionale dei Tumori, SC Oncologia Medica 2, Milano, , Italy
Divisione di Oncologia, AORN Antonio Cardarelli, Napoli, , Italy
Istituto per lo Studio e la Cura dei Tumori Fondazione Pascale, Napoli, , Italy
Unita' Operativa Oncologia Medica 2, Regione del Veneto, Padova, , Italy
IRCCS Policlinico San Matteo, Pavia, , Italy
Struttura Complessa di Oncologia Medica A, Roma, , Italy
Azienda Ospedaliera San Camillo Forlanini, Oncologia Medica, Padiglione Flajani, I piano, Roma, , Italy
UO di Oncologia ed Ematologia, Istituto Clinico Humanitas, Rozzano (MI), , Italy
Sapporo Medical University School of Medicine, Sapporo-shi, Hokkaido, Japan
Hokkaido University Hospital, Sapporo, Hokkaido, Japan
University of Tsukuba, Graduate School of Comprehensive Human Sciences, Department of Urology, Tsukuba, Ibaraki, Japan
Kinki University Hospital, Osakasayama, Osaka, Japan
Hamamatsu University School of Medicine, Hamamatsu-City, Shizuoka, Japan
Shizuoka Cancer Center, Sunto-gun, Shizuoka, Japan
Tokyo Women's Medical University Medical Center East, Department of Urology, Arakawa-ku, Tokyo, Japan
National Cancer Center Hospital, Chuo-Ku, Tokyo, Japan
Nihon University Itabashi Hospital, Itabashi-ku, Tokyo, Japan
Keio University Hospital, Shinjuku-ku, Tokyo, Japan
Tokyo Women's Medical University Hospital, Shinjuku-ku, Tokyo, Japan
Yamaguchi University Hospital, Ube-shi, Yamaguchi, Japan
Akita University Hospital, Akita, , Japan
Chiba Cancer Center, Chiba, , Japan
Kyushu University Hospital, Fukuoka, , Japan
Kumamoto University Hospital, Kumamoto, , Japan
Tokushima University, Tokushima, , Japan
Yamagata University Hospital, Yamagata, , Japan
National Cancer Center, Urologic Oncology Clinic, Center for Specific Organs Cancer, Goyang-si, Gyeonggi-do, Korea, Republic of
Dong-A University Medical Center, Department of Medicine, Division of Hemato-Oncology, Busan, , Korea, Republic of
Seoul National University Hospital, Seoul, , Korea, Republic of
Severance Hospital, Seoul, , Korea, Republic of
Samsung Medical Center, Seoul, , Korea, Republic of
Catholic University of Korea, Seoul St. Mary's Hospital, Department of Oncology, Seoul, , Korea, Republic of
Centrum Medyczne HCP, Poznan, Wielkopolska, Poland
Wielkopolskie Centrum Onkologii im.Marii Sklodowskiej-Curie, Poznan, Wielkopolska, Poland
Wojewodzkie Centrum Onkologii, Gdansk, , Poland
Klinika Onkologii, Szpital Kliniczny Przemienienia Panskiego Uniwersytetu Medycznego, Poznan, , Poland
Pracownia Tomografii Komputerowej, Poznan, , Poland
Klinika Onkologii, Wojskowy Instytut Medyczny, Warszawa, , Poland
Klinika Urologii i Onkologii Urologicznej, Wroclaw, , Poland
Medical Radiology Research Center of the Minzdravsotsrazvitiya of Russia, Obninsk, Kaluga Region, Russian Federation
Cancer Research Center named after N.N. Blokhin, Biotherapy Department, Moscow, , Russian Federation
Cancer Research Center named after N.N.Blokhin, Chemotherapy Department, Moscow, , Russian Federation
Russian Research Center of Roentgenology and Radiology, Moscow, , Russian Federation
The Main Clinical Hospital of the Ministry of Internal Affairs of Russian Federation, Moscow, , Russian Federation
Moscow Research Institute of Oncology P.A. Herzen, Moscow, , Russian Federation
City Clinical Oncology Dispensary, St. Petersburg, , Russian Federation
National Cancer Centre Singapore, Singapore, , Singapore
Onkologicky Ustav sv. Alzbety, Bratislava, , Slovakia
Narodny Onkologicky ustav, Bratislava, , Slovakia
Nemocnica s poliklinikou Zilina, Zilina, , Slovakia
Institut Catala D'Oncologia L'Hospitalet, L'hospitalet de Llobregat, Barcelona, Spain
Clinica Universitaria de Navarra, Pamplona, Navarra, Spain
Hospital de Navarra, Pamplona, Navarra, Spain
Hospital Vall D¿Hebron, Barcelona, , Spain
Hospital Universitario Ramon Y Cajal, Madrid, , Spain
Hospital Universitario 12 de Octubre, Madrid, , Spain
Hospital Clinico Universitario Virgen de La Victoria, Malaga, , Spain
Hospital Universitario Virgen Macarena, Sevilla, , Spain
Hospital Universitario Miguel Servet, Zaragoza, , Spain
Universitetssjukhuset, Onkologiska kliniken, Linkoping, , Sweden
Norrlands Universitetssjukhus, Onkologkliniken, Umea, , Sweden
Onkologkliniken, Vaxjo, , Sweden
Chang Gung Medical Foundation-Kaohsiung Branch, Kaohsiung Hsien, , Taiwan
Taichung Veterans General Hospital, Department of Surgery, Taichung, , Taiwan
Department of Oncology, National Taiwan University Hospital, Taipei, , Taiwan
Chang Gung Medical Foundation-Linkou Branch, Taoyuan, , Taiwan
Royal Marsden Hospital, London, England, United Kingdom
Mount Vernon Cancer Centre, Northwood, Middlesex, United Kingdom
Clatterbridge Centre for Oncology NHS Foundation Trust, Bebington, Wirral, , United Kingdom
University of Birmingham, CRUK Institute for Cancer Studies, Birmingham, , United Kingdom
Royal Bournemouth & Poole Hospitals, Bournemouth, , United Kingdom
Bristol Haematology and Oncology Centre, Bristol, , United Kingdom
Addenbrooke's Hospital, Cambridge, , United Kingdom
The Beatson West of Scotland Cancer Centre, Glasgow, , United Kingdom
Department of Medical Oncology, St. Bartholomew's Hospital, London, , United Kingdom
University Department of Medical Oncology/Oxford Cancer Centre, Oxford, , United Kingdom
Royal Marsden Hospital NHS Foundation Trust, Surrey, , United Kingdom
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