Spots Global Cancer Trial Database for The Impact of Ureteral Stents on Peristalsis

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Trial Identification

Brief Title: The Impact of Ureteral Stents on Peristalsis

Official Title: The Impact of Ureteral Stents on Peristalsis

Study ID: NCT01739738

Conditions

Kidney Stones

Tumor

Hydronephrosis

Interventions

Ureteral Stent

Study Description

Brief Summary: The purpose of the study is to investigate the impact of ureteral stents on the functioning of ureteral peristalsis (normal contractions in the ureteral organ muscle).

Detailed Description: Ureteral stents are commonly used in the field of urology to maintain urinary drainage and are inserted into ureters of patients who suffer from kidney stones, urinary tract infections or cancer. Usually the muscle cells of the ureter contract in a coordinated fashion (peristalsis) in order to provide urinary flow from the kidney into the bladder. By inserting a stent these contractions are disrupted, eventually resulting in a loss of peristalsis. This phenomena is accompanied by swelling of the kidney and pain, which are well-known negative side effects of stents. To avoid stent-related morbidity and improve patients care this issue needs to be investigated further. A first step is to analyse the impact of stents on peristalsis and to possibly bring these results into context with hypothesised molecular mechanisms involved in peristalsis.