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Spots Global Cancer Trial Database for Natural Killer Cell (CYNK-001) Infusions in Adults With AML

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Trial Identification

Brief Title: Natural Killer Cell (CYNK-001) Infusions in Adults With AML

Official Title: A Phase I Multi-dose Study of Human Placental Hematopoietic Stem Cell Derived Natural Killer Cells (CYNK-001) With or Without Recombinant Human Interleukin-2 (rhIL-2) in Adults With Primary or Secondary Acute Myeloid Leukemia (AML) in Morphologic Complete Remission With Minimal Residual Disease (MRD) or Relapsed/Refractory (R/R) AML

Study ID: NCT04310592

Interventions

CYNK-001

Study Description

Brief Summary: This study will find the maximum tolerated dose or the maximum planned dose of CYNK-001 which contains natural killer (NK) cells derived from human placental CD34+ cells and culture-expanded. CYNK-001 cells will be given after lymphodepleting chemotherapy. The safety of this treatment will be evaluated, and researchers want to learn if NK cells will help in treating acute myeloid leukemia.

Detailed Description:

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Colorado Blood Cancer Institute, Denver, Colorado, United States

University of Chicago, Chicago, Illinois, United States

Hackensack University Medical Center, Hackensack, New Jersey, United States

Roswell Park Comprehensive Cancer Center, Buffalo, New York, United States

Columbia University and New York Presbyterian Hospital, New York, New York, United States

Memorial Sloan Kettering Cancer Center, New York, New York, United States

Westchester Medical Center, Valhalla, New York, United States

Tennessee Oncology, Nashville, Tennessee, United States

MD Anderson Cancer Center, Houston, Texas, United States

Swedish Health Services, Seattle, Washington, United States

Contact Details

Name: Cherie Daly, MD

Affiliation: Celularity, Inc.

Role: STUDY_DIRECTOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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