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Spots Global Cancer Trial Database for Study of Blood and Bone Marrow Samples in Patients With Chronic Myelogenous Leukemia Enrolled on a CALGB Clinical Trial

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Study of Blood and Bone Marrow Samples in Patients With Chronic Myelogenous Leukemia Enrolled on a CALGB Clinical Trial

Official Title: Molecular and Cytogenetic Monitoring of CML - A Mandatory Companion to CALGB 19804

Study ID: NCT01004640

Conditions

Leukemia

Study Description

Brief Summary: RATIONALE: Studying samples of blood and bone marrow from patients with cancer may help doctors identify biomarkers related to cancer. PURPOSE: This research study is looking at blood and bone marrow samples in patients with chronic myelogenous leukemia enrolled on a CALGB clinical trial.

Detailed Description: OBJECTIVES: * Monitor molecular response rates of patients receiving treatment for chronic myelogenous leukemia by quantitative reverse transcription polymerase chain reaction (RT-PCR) and quantitative Southern blot monitoring of blood samples. * Compare quantitative RT-PCR and quantitative Southern blot results with marrow cytogenetics at the time of complete molecular response in these patients. * Monitor the frequency of residual disease in patients who achieve a complete blood Southern blot and marrow cytogenetic response (eradication of BCR/ABL by Southern blot and absence of the Philadelphia chromosome by cytogenetics). OUTLINE: Peripheral blood samples and bone marrow aspirates are collected at baseline and at 3, 6, and 9 months after starting therapy. If patient continues to receive protocol treatment after 9 months, additional peripheral blood samples are collected every 6 months and bone marrow aspirates are taken annually. In the event of disease progression (blast crisis), an additional peripheral blood sample and bone marrow aspirate are collected. Samples are examined by quantitative Southern blot analysis with probes to BCR, quantitative reverse transcriptase-polymerase chain reaction analysis for BCR/ABL fusion transcripts, and cytogenetic analysis. PROJECTED ACCRUAL: A total of 60 patients will be accrued for this study within 1.5 years.

Eligibility

Minimum Age:

Eligible Ages: CHILD, ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Naval Medical Center - San Diego, San Diego, California, United States

UCSF Medical Center-Mount Zion, San Francisco, California, United States

Beebe Medical Center, Lewes, Delaware, United States

Christiana Care Health Services, Newark, Delaware, United States

Nanticoke Memorial Hospital, Seaford, Delaware, United States

Saint Francis Hospital - Wilmington, Wilmington, Delaware, United States

Washington Hospital Center, Washington, District of Columbia, United States

Lombardi Comprehensive Cancer Center at Georgetown University Medical Center, Washington, District of Columbia, United States

Holy Cross Hospital, Fort Lauderdale, Florida, United States

Broward Health Medical Center, Fort Lauderdale, Florida, United States

Memorial Healthcare System - Joe DiMaggio Children's Hospital, Hollywood, Florida, United States

Jupiter Medical Center, Jupiter, Florida, United States

Mount Sinai Medical Center, Miami Beach, Florida, United States

Illinois CancerCare-Bloomington, Bloomington, Illinois, United States

Saint Joseph Medical Center, Bloomington, Illinois, United States

Graham Hospital Assocation, Canton, Illinois, United States

Illinois CancerCare-Canton, Canton, Illinois, United States

Illinois CancerCare-Carthage, Carthage, Illinois, United States

Memorial Hospital, Carthage, Illinois, United States

Mount Sinai Hospital Medical Center, Chicago, Illinois, United States

University of Illinois Cancer Center, Chicago, Illinois, United States

Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois, United States

University of Chicago Cancer Research Center, Chicago, Illinois, United States

Weiss Memorial Hospital, Chicago, Illinois, United States

Eureka Hospital, Eureka, Illinois, United States

Illinois CancerCare-Eureka, Eureka, Illinois, United States

Galesburg Cottage Hospital, Galesburg, Illinois, United States

Illinois CancerCare Galesburg, Galesburg, Illinois, United States

Western Illinois Cancer Treatment Center, Galesburg, Illinois, United States

Illinois CancerCare-Cottage, Galesburg, Illinois, United States

Illinois Oncology Limited, Granite City, Illinois, United States

Illinois CancerCare-Havana, Havana, Illinois, United States

Mason District Hospital, Havana, Illinois, United States

Hopedale Medical Complex - Hospital, Hopedale, Hopedale, Illinois, United States

Illinois CancerCare-Kewanee Clinic, Kewanee, Illinois, United States

Kewanee Hospital, Kewanee, Illinois, United States

Illinois CancerCare-Macomb, Macomb, Illinois, United States

Mcdonough District Hospital, Macomb, Illinois, United States

Holy Family Medical Center, Monmouth, Illinois, United States

Illinois CancerCare-Monmouth, Monmouth, Illinois, United States

Community Cancer Center Foundation, Normal, Illinois, United States

Illinois CancerCare-Community Cancer Center, Normal, Illinois, United States

Bromenn Regional Medical Center, Normal, Illinois, United States

Illinois CancerCare- Ottawa Clinic, Ottawa, Illinois, United States

Ottwa Regional Hospital and Healthcare, Ottawa, Illinois, United States

Illinois CancerCare- Pekin, Pekin, Illinois, United States

Pekin Cancer Treatment Center, Pekin, Illinois, United States

Pekin Hospital, Pekin, Illinois, United States

Methodist Medical Center of Illinois, Peoria, Illinois, United States

Proctor Hospital, Peoria, Illinois, United States

Illinois CancerCare- Peoria, Peoria, Illinois, United States

Illinois Oncology Research Association-CCOP, Peoria, Illinois, United States

OSF Saint Francis Medical Center, Peoria, Illinois, United States

Illinois CancerCare- Peru, Peru, Illinois, United States

Illinois Valley Hospital, Peru, Illinois, United States

Valley Radiation Oncology, Peru, Illinois, United States

Illinois CancerCare- Princeton, Princeton, Illinois, United States

Perry Memorial Hospital, Princeton, Illinois, United States

Sarah Culberston Memorial Hospital, Rushville, Illinois, United States

Illinois CancerCare- Spring Valley, Spring Valley, Illinois, United States

Saint Margaret's Hospital, Spring Valley, Illinois, United States

Elkhart General Hospital, Elkhart, Indiana, United States

Fort Wayne Medical Oncology and Hematology, Fort Wayne, Indiana, United States

Community Howard Regional Health, Kokomo, Indiana, United States

IU Health La Porte Hospital, La Porte, Indiana, United States

Saint Joseph Regional Medical Center - Mishawaka, Mishawaka, Indiana, United States

Memorial Hospital of South Bend, South Bend, Indiana, United States

Northern Indiana Cancer Research Consrtium, South Bend, Indiana, United States

Physicians' Clinic of Iowa PC, Cedar Rapids, Iowa, United States

Mercy Hospital, Cedar Rapids, Iowa, United States

Saint Luke's Hospital, Cedar Rapids, Iowa, United States

Holden Comprehensive Cancer Center at University of Iowa, Iowa City, Iowa, United States

University of Iowa Hospitals and Clinics, Iowa City, Iowa, United States

CancerCare of Maine at Eastern Maine Medical Center, Bangor, Maine, United States

Eastern Maine Medical Center, Bangor, Bangor, Maine, United States

Greenebaum Cancer Center at University of Maryland Medical Center, Baltimore, Maryland, United States

University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland, United States

Union Hospital Cancer Program at Union Hospital, Elkton, Maryland, United States

Massachusetts General Hospital, Boston, Massachusetts, United States

Brigham and Women's Hospital, Boston, Massachusetts, United States

Dana-Farber Cancer Institute, Boston, Massachusetts, United States

Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States

Commonwealth Hematology Oncology PC-Worcester, Worcester, Worcester, Massachusetts, United States

University of Massachusetts Medical School, Worcester, Massachusetts, United States

Oncology Care Associates PLLC, Saint Joseph, Michigan, United States

Missouri Cancer Associates, Columbia, Missouri, United States

Veterans Administration, Columbia, Missouri, United States

Ellis Fischel Cancer Center at University of Missouri - Columbia, Columbia, Missouri, United States

University of Missouri - Ellis Fischel,, Columbia, Missouri, United States

Capital Regional Medical Center, Jefferson City, Missouri, United States

Lakeland Hospital, Saint Joseph, Missouri, United States

Washington University School of Medicine, Saint Louis, Missouri, United States

Missouri Baptist Cancer Center, Saint Louis, Missouri, United States

Missouri Baptist Medical Center, Saint Louis, Missouri, United States

Arch Medical Services, Incorporated at Center for Cancer Care and Research, Saint Louis, Missouri, United States

Center for Cancer Care and Research, Saint Louis, Missouri, United States

Comprehensive Cancer Care, PC, Saint Louis, Missouri, United States

University Medical Center of Southern Nevada, Las Vegas, Nevada, United States

CCOP - Nevada Cancer Research Foundation, Las Vegas, Nevada, United States

Nevada Cancer Research Foundation CCOP, Las Vegas, Nevada, United States

Valley Regional, Claremont, New Hampshire, United States

Cheshire Medical Center-Dartmouth-Hitchcock Keene, Keene, New Hampshire, United States

Weeks Memorial Hospital, Lancaster, New Hampshire, United States

Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, United States

Alice Peck Day Memorial Hospital, Lebanon, New Hampshire, United States

Frisbie Hospital, Rochester, New Hampshire, United States

Cooper Hospital University Medical Center, Camden, New Jersey, United States

Saint Barnabas Medical Center, Livingston, New Jersey, United States

Cancer Institute of New Jersey at Cooper - Voorhees, Voorhees, New Jersey, United States

Roswell Park Cancer Institute, Buffalo, New York, United States

CCOP - Hematology-Oncology Associates of Central New York, East Syracuse, New York, United States

Elmhurst Hospital Center, Elmhurst, New York, United States

Glens Falls Hospital, Glens Falls, New York, United States

Queens Hospital Center, Jamaica, New York, United States

Mount Sinai Medical Center, New York, New York, United States

Memorial Sloan-Kettering Cancer Center, New York, New York, United States

Weill Medical College of Cornell University, New York, New York, United States

Oswego Hospital, Oswego, New York, United States

Stony Brook University Medical Center, Stony Brook, New York, United States

Hematology Oncology Associates of Central New York-East Syracuse, Syracuse, New York, United States

Saint Joseph's Hospital Health Center, Syracuse, New York, United States

State University of New York Upstate Medical University, Syracuse, New York, United States

SUNY Upstate Medical University Hospital, Syracuse, New York, United States

Syracuse Veterans Administration Medical Center, Syracuse, New York, United States

Veterans Affairs Medical Center - Syracuse, Syracuse, New York, United States

Mission Hospital-Memorial Campus, Asheville, North Carolina, United States

Mission Hospital-Saint Joseph Campus, Asheville, North Carolina, United States

University of North Carolina, Chapel Hill, North Carolina, United States

Carolinas Medical Center, Charlotte, Charlotte, North Carolina, United States

Novant Health Presbyterian Medical Center, Charlotte, North Carolina, United States

Duke University Medical Center, Durham, North Carolina, United States

Wayne Memorial Hospital, Incorporated, Goldsboro, North Carolina, United States

Kinston Medical Specialists, Kinston, North Carolina, United States

Lenoir Memorial Hospital, Kinston, North Carolina, United States

Wilson Medical Center, Wilson, North Carolina, United States

Wake Forest University Comprehensive Cancer Center, Winston-Salem, North Carolina, United States

Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center, Columbus, Ohio, United States

Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States

Western Pennsylvania Cancer Institute at Western Pennsylvania Hospital, Pittsburgh, Pennsylvania, United States

West Penn Hospital, Pittsburgh, Pennsylvania, United States

Medical University of South Carolina, Charleston, South Carolina, United States

Greenville Health System Cancer Institute-Easley, Easley, South Carolina, United States

Saint Francis Hospital, Greenville, South Carolina, United States

Greenville Health System Cancer Institute-Andrews, Greenville, South Carolina, United States

Greenville Health System Cancer Institute-Butternut, Greenville, South Carolina, United States

Greenville Health System Cancer Institute-Faris, Greenville, South Carolina, United States

Greenville Memorial Hospital, Greenville, South Carolina, United States

Greenville Health System Cancer Institute-Eastside, Greenville, South Carolina, United States

Self Regional Healthcare, Greenwood, South Carolina, United States

Cancer Centers of the Carolinas-Green Medial Oncology, Greer, South Carolina, United States

Greenville Health System Cancer Institute-Seneca, Seneca, South Carolina, United States

Greenville Health System Cancer Institute-Spartanburg, Spartanburg, South Carolina, United States

Baptist Memorial Hospital and Cancer Center-Memphis, Memphis, Tennessee, United States

Central Vermont Medical Center/ National Life Cancer Treatment, Berlin, Vermont, United States

Fletcher Allen Health Care - University Health Center Campus, Burlington, Vermont, United States

University of Vermont College of Medicine, Burlington, Vermont, United States

North Country Health, Newport, Vermont, United States

Northeastern, Saint Johnsbury, Vermont, United States

Springfield Hospital, Springfield, Vermont, United States

White River Junction Veteran Administration Medical Center, White River Junction, Vermont, United States

Danville Regional Medical Center, Danville, Virginia, United States

Contact Details

Name: Wendy Stock, MD

Affiliation: University of Chicago

Role: STUDY_CHAIR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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