Spots Global Cancer Trial Database for Biomarkers in Samples From Patients With B-Cell Acute Lymphoblastic Leukemia

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Trial Identification

Brief Title: Biomarkers in Samples From Patients With B-Cell Acute Lymphoblastic Leukemia

Official Title: Micro RNA Expression Analysis in B-Lineage Adult Acute Lymphoblastic Leukemia From ALL Trial, E2993, Including Patients With Various Cytogenetic and Molecular Abnormalities

Study ID: NCT01505699

Conditions

Leukemia

Interventions

RNA analysis

cytogenetic analysis

microarray analysis

laboratory biomarker analysis

Study Description

Brief Summary: RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer. PURPOSE: This research study is studying biomarkers in samples from patients with acute lymphoblastic leukemia enrolled on ECOG-2993 clinical trial.

Detailed Description: OBJECTIVES: * To identify microRNAs that behave as oncogenes or as tumor suppressor genes in B-lineage acute lymphoblastic leukemia (ALL) in vitro and in vivo. * To examine if single microRNA or signatures of microRNA correspond to different clinical outcomes in cytogenetically distinct B-ALL groups. OUTLINE: RNA from archived samples are analyzed for microRNA expression profile in vitro and in vivo.